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公开(公告)号：US11773412B2
公开(公告)日：2023-10-03
申请号：US17848563
申请日：2022-06-24
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , Skolkovo Institute of Science and Technology , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Konstantin Severinov , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Eugene Koonin , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh , Eric S. Lander
IPC分类号： C12N15/90 , C12N15/10 , C12N15/63 , C12N9/22 , C12N15/11 , C12N15/82 , C12N15/85 , C12N15/113
CPC分类号： C12N15/907 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/8201 , C12N15/85 , C12N2310/111 , C12N2310/20 , C12N2800/22
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20220372525A1
公开(公告)日：2022-11-24
申请号：US17848563
申请日：2022-06-24
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , Skolkovo Institute of Science and Technology , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Konstantin Severinov , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Eugene Koonin , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh , Eric S. Lander
IPC分类号： C12N15/90 , C12N15/10 , C12N15/63 , C12N9/22 , C12N15/11 , C12N15/82 , C12N15/85 , C12N15/113
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US11180751B2
公开(公告)日：2021-11-23
申请号：US15842073
申请日：2017-12-14
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, the State University of New Jersey , The United States of America, as represented by the Secretary, Dept. of Health and Human Services , Skolkovo Institute of Science and Technology
发明人： Eugene Koonin , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Konstantin Severinov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20190382800A1
公开(公告)日：2019-12-19
申请号：US16450825
申请日：2019-06-24
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , Skolkovo Institute of Science and Technology , The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
发明人： Konstantin Severinov , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Eugene Koonin , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh , Eric S. Lander
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20210348157A1
公开(公告)日：2021-11-11
申请号：US17246466
申请日：2021-04-30
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , Skolkovo Institute of Science and Technology , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Eugene Koonin , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Konstantin Severinov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20190382801A1
公开(公告)日：2019-12-19
申请号：US16450852
申请日：2019-06-24
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , Skolkovo Institute of Science and Technology , The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
发明人： Konstantin Severinov , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Eugene Koonin , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh , Eric S. Lander
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20240182928A1
公开(公告)日：2024-06-06
申请号：US18235760
申请日：2023-08-18
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , Skolkovo Institute of Science and Technology , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Konstantin Severinov , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Eugene Koonin , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh , Eric S. Lander
IPC分类号： C12N15/90 , C12N9/22 , C12N15/10 , C12N15/11 , C12N15/113 , C12N15/63 , C12N15/82 , C12N15/85
CPC分类号： C12N15/907 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/8201 , C12N15/85 , C12N2310/111 , C12N2310/20 , C12N2800/22
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US11421250B2
公开(公告)日：2022-08-23
申请号：US15844530
申请日：2017-12-16
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , The United States of America, as represented by the Secretary, Dept. of Health and Human Services , Skolkovo Institute of Science and Technology
发明人： Konstantin Severinov , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Eugene Koonin , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh , Eric S. Lander
IPC分类号： C12N15/90 , C12N15/10 , C12N15/63 , C12N9/22 , C12N15/11 , C12N15/82 , C12N15/85 , C12N15/113
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20210348156A1
公开(公告)日：2021-11-11
申请号：US17246460
申请日：2021-04-30
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , Skolkovo Institute of Science and Technology , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Eugene Koonin , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Konstantin Severinov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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公开(公告)号：US20180327786A1
公开(公告)日：2018-11-15
申请号：US15844530
申请日：2017-12-16
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , Rutgers, The State University of New Jersey , The United States Of America, As Represented By, The Secretary Department of Health And Human Servi , Skolkovo Institute of Science and Technology
发明人： Konstantin Severinov , Feng Zhang , Yuri I. Wolf , Sergey Shmakov , Ekaterina Semenova , Leonid Minakhin , Kira S. Makarova , Eugene Koonin , Silvana Konermann , Julia Joung , Jonathan S. Gootenberg , Omar O. Abudayyeh , Eric S. Lander
IPC分类号： C12N15/90 , C12N9/22 , C12N15/11 , C12N15/10 , C12N15/113
CPC分类号： C12N15/907 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/113 , C12N15/63 , C12N15/8201 , C12N15/85 , C12N2310/111 , C12N2310/20 , C12N2800/22
摘要： The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
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