公开(公告)号：US20240024368A1

公开(公告)日：2024-01-25

申请号：US18352730

申请日：2023-07-14

申请人： The Children's Medical Center Corporation

发明人： Zhigang HE ,  Shane HEGARTY ,  Feng TIAN ,  Joanna STANICKA ,  Songlin ZHOU

IPC分类号： A61K35/30 ,  A61P25/28 ,  C12N5/0793 ,  C12N15/11 ,  C12N9/22 ,  C12N15/90

CPC分类号： A61K35/30 ,  A61P25/28 ,  C12N5/0619 ,  C12N15/11 ,  C12N9/22 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

摘要： As described below, the present invention features compositions and methods for neuroprotection and/or neuroregeneration of damaged or degenerating neurons. In various embodiments, the compositions and methods of the present disclosure are used to treat a neurodegenerative disease and/or nervous system injury. The methods in various embodiments include reducing or eliminating activity or expression of a target gene(s) and/or a polypeptide(s) expressed by a target gene(s) in a neuron.