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公开(公告)号：US20240361337A1
公开(公告)日：2024-10-31
申请号：US18660434
申请日：2024-05-10
Applicant: The Curators of the University of Missouri
Inventor： James L. Cook , Aaron M. Stoker , Chantelle C. Bozynski , Keiichi Kuroki , Cristi R. Cook , Emily Leary
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N2800/60
Abstract: Methods for predicting canine hip dysplasia (CHD) in an immature canine subject are provided. The methods include the use of concentration profiles of a plurality of polypeptides, including C2C, CTX-I, CTX-II, RANKL, PIICP, COMP, PINP. Also provided are CHD biomarker profiles for predicting or diagnosing CHD in immature or young canines before CHD develops. Diagnostic reagents and kits for the same are also provided.
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公开(公告)号：US20190059911A1
公开(公告)日：2019-02-28
申请号：US16107671
申请日：2018-08-21
Applicant: The Curators of the University of Missouri
Inventor： Ferris M. Pfeiffer , Aaron M. Stoker , James L. Cook
Abstract: Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may be adapted to contract from a first diameter to a second diameter that is less than the first diameter. The contraction of the cutting surface from the first diameter to the second diameter may define a tapered profile between the first diameter and the second diameter suitable for obtaining a tapered graft.
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公开(公告)号：US10080570B2
公开(公告)日：2018-09-25
申请号：US15582287
申请日：2017-04-28
Applicant: The Curators of the University of Missouri
Inventor： Ferris M. Pfeiffer , Aaron M. Stoker , James L. Cook
CPC classification number: A61B17/1635 , A61B17/16 , A61B17/1604 , A61B17/1613 , A61B17/1615 , A61B17/1622 , A61B17/3417 , A61B17/3439 , B23B51/04 , B23B51/0406 , B23B51/0413 , B23B51/0453 , B23B51/05 , B23B2251/428 , B23B2251/54
Abstract: Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may be adapted to contract from a first diameter to a second diameter that is less than the first diameter. The contraction of the cutting surface from the first diameter to the second diameter may define a tapered profile between the first diameter and the second diameter suitable for obtaining a tapered graft.
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公开(公告)号：US09488646B2
公开(公告)日：2016-11-08
申请号：US14175254
申请日：2014-02-07
Applicant: The Curators of the University of Missouri
Inventor： James L. Cook , Cristi R. Cook , Aaron M. Stoker , Keiichi Kuroki , Bridget Colleen Garner , Richard Evans , Brandon Lee Roller , Prakash Sidha Jayabalan
CPC classification number: G01N33/6887 , C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , G01N33/5308 , G01N2333/52 , G01N2333/5421 , G01N2800/105 , G01N2800/56
Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
Abstract translation: 公开了用于诊断骨关节炎（OA）和确定治疗的生物标志物，生物标志物组和方法，使用来自受试者的测试样品中某些多肽的表达水平的测量，包括MCP1，IL8，KC，MMP2，MMP3，载脂蛋白A1和 载脂蛋白E.还描述了用于监测OA治疗功效，诊断试剂和试剂盒的相关方法。
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Patent Agency Ranking
公开(公告)号：US20140155499A1
公开(公告)日：2014-06-05
申请号：US14175254
申请日：2014-02-07
Applicant: The Curators of the University of Missouri
Inventor： James L. Cook , Cristi R. Cook , Aaron M. Stoker , Keiichi Kuroki , Bridget Colleen Garner , Richard Evans , Brandon Lee Roller , Prakash Sidha Jayabalan
IPC: G01N33/53
CPC classification number: G01N33/6887 , C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , G01N33/5308 , G01N2333/52 , G01N2333/5421 , G01N2800/105 , G01N2800/56
Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
Abstract translation: 公开了用于诊断骨关节炎（OA）和确定治疗的生物标志物，生物标志物组和方法，使用来自受试者的测试样品中某些多肽的表达水平的测量，包括MCP1，IL8，KC，MMP2，MMP3，载脂蛋白A1和 载脂蛋白E.还描述了用于监测OA治疗功效，诊断试剂和试剂盒的相关方法。
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公开(公告)号：US20170030925A1
公开(公告)日：2017-02-02
申请号：US15290613
申请日：2016-10-11
Applicant: The Curators of the University of Missouri
Inventor： James L. Cook , Cristi R. Cook , Aaron M. Stoker , Keiichi Kuroki , Bridget Colleen Garner , Richard Evans , Brandon Lee Roller , Prakash Sidha Jayabalan
IPC: G01N33/68
CPC classification number: G01N33/6887 , C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , G01N33/5308 , G01N2333/52 , G01N2333/5421 , G01N2800/105 , G01N2800/56
Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
Abstract translation: 公开了用于诊断骨关节炎（OA）和确定治疗的生物标志物，生物标志物组和方法，使用来自受试者的测试样品中某些多肽的表达水平的测量，包括MCP1，IL8，KC，MMP2，MMP3，载脂蛋白A1和 载脂蛋白E.还描述了用于监测OA治疗功效，诊断试剂和试剂盒的相关方法。
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公开(公告)号：US20210239711A1
公开(公告)日：2021-08-05
申请号：US17168871
申请日：2021-02-05
Applicant: The Curators of the University of Missouri
Inventor： James L. Cook , Aaron M. Stoker , Chantelle C. Bozynski , Keiichi Kuroki , Cristi R. Cook , Emily Leary
IPC: G01N33/68
Abstract: Methods for predicting canine hip dysplasia (CHD) in an immature canine subject are provided. The methods include the use of concentration profiles of a plurality of polypeptides, including C2C, CTX-I, CTX-II, RANKL, PIICP, COMP, PINP. Also provided are CHD biomarker profiles for predicting or diagnosing CHD in immature or young canines before CHD develops. Diagnostic reagents and kits for the same are also provided.
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公开(公告)号：US20170281198A1
公开(公告)日：2017-10-05
申请号：US15582287
申请日：2017-04-28
Applicant: The Curators of the University of Missouri
Inventor： Ferris M. Pfeiffer , Aaron M. Stoker , James L. Cook
IPC: A61B17/16
CPC classification number: A61B17/1635 , A61B17/16 , A61B17/1604 , A61B17/1613 , A61B17/1615 , A61B17/1622 , A61B17/3417 , A61B17/3439 , B23B51/04 , B23B51/0406 , B23B51/0413 , B23B51/0453 , B23B51/05 , B23B2251/428 , B23B2251/54
Abstract: Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may be adapted to contract from a first diameter to a second diameter that is less than the first diameter. The contraction of the cutting surface from the first diameter to the second diameter may define a tapered profile between the first diameter and the second diameter suitable for obtaining a tapered graft.
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公开(公告)号：US09733257B2
公开(公告)日：2017-08-15
申请号：US15290613
申请日：2016-10-11
Applicant: The Curators of the University of Missouri
Inventor： James L. Cook , Cristi R. Cook , Aaron M. Stoker , Keiichi Kuroki , Bridget Colleen Garner , Richard Evans , Brandon Lee Roller , Prakash Sidha Jayabalan
CPC classification number: G01N33/6887 , C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , G01N33/5308 , G01N2333/52 , G01N2333/5421 , G01N2800/105 , G01N2800/56
Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
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