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    THERAPEUTIC PARTICLES THAT ENABLE ANTIGEN PRESENTING CELLS TO ATTACK CANCER CELLS
    2.
    发明申请
    THERAPEUTIC PARTICLES THAT ENABLE ANTIGEN PRESENTING CELLS TO ATTACK CANCER CELLS 有权

    公开(公告)号：US20220177912A1

    公开(公告)日：2022-06-09

    申请号：US17601812

    申请日：2020-04-13

    申请人： The Methodist Hospital

    发明人： Haifa Shen ,  Gang Li

    IPC分类号： C12N15/85 ,  A61K35/15 ,  C07K16/30 ,  C07K14/705 ,  A61P35/00

    摘要： Embodiments of the present disclosure pertain to modified antigen presenting cells that include a recombinant protein appended onto a surface of the antigen presenting cells. The recombinant protein can include: an ectodomain positioned on the surface; a transmembrane domain with a region embedded in the cell membrane; an antigen presenting cell recruiting domain that directs the cells towards the cancer cells; and an antigen presenting cell activator that activates or licenses the antigen presenting cells. Additional embodiments of the present disclosure pertain to methods of expressing the recombinant proteins on antigen presenting cells and utilizing the modified antigen presenting cells for treating various cancers in various subjects. Further embodiments of the present disclosure pertain to nucleotide-containing carriers for expressing the recombinant proteins of the present disclosure in antigen presenting cells.

    POLYCATION-FUNCTIONALIZED NANOPOROUS SILICON CARRIER FOR SYSTEMIC DELIVERY OF GENE SILENCING AGENTS
    3.
    发明申请
    POLYCATION-FUNCTIONALIZED NANOPOROUS SILICON CARRIER FOR SYSTEMIC DELIVERY OF GENE SILENCING AGENTS 审中-公开
    用于系统输送基因沉默剂的聚合官能化纳米硅载体

    公开(公告)号：US20160369269A1

    公开(公告)日：2016-12-22

    申请号：US14967165

    申请日：2015-12-11

    申请人： The Methodist Hospital

    发明人： Haifa Shen ,  Mauro Ferrari ,  Jian Shen ,  Mingzhen Zhang

    IPC分类号： C12N15/113 ,  A61K9/51 ,  A61K31/7088 ,  A61K9/50

    CPC分类号： C12N15/113 ,  A61K9/5031 ,  A61K9/5146 ,  A61K31/7088 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

    摘要： Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.

    摘要翻译： 公开了含有官能化纳米多孔硅颗粒的方法和组合物，其可用于将遗传构建体递送到感兴趣的一个或多个细胞，组织和/或器官的各种诊断和/或治疗方案中。 还提供了将选择的宿主细胞引入一个或多个选择的核酸分子的方法。 本公开还涉及治疗肿瘤的方法，其包括向个体施用本文所述的一种或多种组合物和制剂的步骤。

    Core/shell structure platform for immunotherapy
    5.
    发明授权
    Core/shell structure platform for immunotherapy 有权

    公开(公告)号：US11382964B2

    公开(公告)日：2022-07-12

    申请号：US15881637

    申请日：2018-01-26

    申请人： The Methodist Hospital

    发明人： Haifa Shen

    IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  A61K39/39 ,  A61K47/69 ,  A61K47/64 ,  A61K9/00

    摘要： Disclosed are biocompatible core/shell compositions suitable for the delivery of populations of mRNA molecules to mammalian cells. The disclosed core-shell structured multicomponent compositions are optimized for the delivery of mRNAs encoding one or more cancer- or tumor-specific antigens to a population of antigen presenting cells, including, for example, human dendritic cells, macrophages and B cells. Also disclosed are methods for use of these compositions as therapeutic cancer vaccines.

    COMPOSITIONS AND METHODS OF TREATING THERAPY RESISTANT CANCER AND USES THEREOF
    6.
    发明申请
    COMPOSITIONS AND METHODS OF TREATING THERAPY RESISTANT CANCER AND USES THEREOF 有权

    公开(公告)号：US20210059942A1

    公开(公告)日：2021-03-04

    申请号：US17096268

    申请日：2020-11-12

    申请人： The Methodist Hospital Research Institute

    发明人： Haifa Shen ,  Mauro Ferrari ,  Xiaoyong Deng ,  Guodong Zhang

    IPC分类号： A61K9/14 ,  A61K47/64

    摘要： The present disclosure is directed to a composition for the sustained-release delivery of an active agent to a target cell of an individual. The compositions disclosed herein comprise of at least one porous particle; at least one polymer; and at least one active agent. In an embodiment, the porous particle comprises a plurality of microscale reservoirs. In an exemplary embodiment, the at least one active agent is covalently linked to the at least one polymer to form a polymer-active agent conjugate, and the polymer-active agent conjugate is contained in the plurality of microscale reservoirs of the porous particle. In some embodiments, the active agent is released with zero-order or near zero-order kinetics following administration of the composition. The present disclosure is also directed to a method of treating a tumor by administering to an individual the composition described supra.