公开(公告)号：US09439976B2

公开(公告)日：2016-09-13

申请号：US14179379

申请日：2014-02-12

申请人： The Methodist Hospital System ,  Board of Regents, The University of Texas System

发明人： Ching-Hsuan Tung ,  Wael Refat Adb-Elgaliel ,  Craig D. Logsdon ,  Zobeida Cruz-Monserrate

IPC分类号： A61K45/00 ,  C07K16/00 ,  A61K47/48 ,  A61K41/00 ,  A61K45/06 ,  G01N33/574

CPC分类号： A61K47/48246 ,  A61K41/0057 ,  A61K41/0061 ,  A61K45/06 ,  A61K47/64 ,  G01N33/57484

摘要： Provided herein are compositions and kits comprising a therapeutic agent linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E. Also provided are methods of treating one or more symptoms of a disease or disorder characterized by expression of cathepsin E in a subject and methods of eliminating a cancer cell characterized by expression of cathepsin E using the provided compositions and kits. Further provided herein are methods of detecting the presence of a cancer cell or detecting a cathepsin E expressing cell using a photosensitizer linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E.

摘要翻译： 本文提供了包含与可切割底物连接的治疗剂的组合物和试剂盒，其中可切割底物能够被组织蛋白酶E切割。还提供了治疗以组织蛋白酶E表达为特征的疾病或病症的一种或多种症状的方法 以及使用提供的组合物和试剂盒消除以组织蛋白酶E表达为特征的癌细胞的方法。 本文进一步提供了使用连接到可切割底物的光敏剂来检测癌细胞的存在或检测表达组织蛋白酶E的细胞的方法，其中可切割底物能够被组织蛋白酶E切割。

公开(公告)号：US20140227188A1

公开(公告)日：2014-08-14

申请号：US14179379

申请日：2014-02-12

申请人： Board of Regents, The University of Texas System ,  The Methodist Hospital System

发明人： Chin-Hsuan Tung ,  Wael Refat Adb-Elgaliel ,  Craig D. Logsdon ,  Zobeida Cruz-Monserrate

IPC分类号： A61K47/48 ,  G01N33/50 ,  A61K49/00 ,  A61K41/00 ,  A61K45/06

CPC分类号： A61K47/48246 ,  A61K41/0057 ,  A61K41/0061 ,  A61K45/06 ,  A61K47/64 ,  G01N33/57484

摘要： Provided herein are compositions and kits comprising a therapeutic agent linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E. Also provided are methods of treating one or more symptoms of a disease or disorder characterized by expression of cathepsin E in a subject and methods of eliminating a cancer cell characterized by expression of cathepsin E using the provided compositions and kits. Further provided herein are methods of detecting the presence of a cancer cell or detecting a cathepsin E expressing cell using a photosensitizer linked to a cleavable substrate, wherein the cleavable substrate is capable of being cleaved by cathepsin E.

摘要翻译： 本文提供了包含与可切割底物连接的治疗剂的组合物和试剂盒，其中可切割底物能够被组织蛋白酶E切割。还提供了治疗以组织蛋白酶E表达为特征的疾病或病症的一种或多种症状的方法 以及使用提供的组合物和试剂盒消除以组织蛋白酶E表达为特征的癌细胞的方法。 本文进一步提供了使用连接到可切割底物的光敏剂来检测癌细胞的存在或检测表达组织蛋白酶E的细胞的方法，其中可切割底物能够被组织蛋白酶E切割。