公开(公告)号：US11007281B2

公开(公告)日：2021-05-18

申请号：US15939104

申请日：2018-03-28

Applicant: The regents of the University of California

Inventor： Joseph Wang ,  Berta Esteban-Fernández de Ávila ,  Yi Chen ,  Chava Angell ,  Fernando Soto ,  Liangfang Zhang ,  Malthe Hansen-Bruhn

IPC: A61K48/00 ,  A61K38/48 ,  A61K41/00 ,  A61M31/00 ,  A61M37/00 ,  C12N15/11 ,  C12N15/113 ,  C12N9/22 ,  C12N9/64 ,  C12N15/87 ,  B82Y15/00

Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.

公开(公告)号：US20190070314A1

公开(公告)日：2019-03-07

申请号：US15939104

申请日：2018-03-28

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Berta Esteban-Fernández de Ávila ,  Yi Chen ,  Chava Angell ,  Fernando Soto Alvarez ,  Liangfang Zhang ,  Malthe Hansen-Bruhn

IPC: A61K48/00 ,  A61M31/00 ,  A61M37/00 ,  A61K41/00 ,  C12N15/113 ,  C12N9/22 ,  C12N15/11 ,  C12N9/64 ,  A61K38/48

Abstract: Methods, systems, and devices are disclosed for intracellular payload delivery by nanomotor structures. In some aspects, a nanomotor for intracellular payload delivery includes an asymmetric body having a concave cavity at one end of the nanowire body; a functionalization layer on an outer surface of the nanowire body; and a payload substance coupled to the nanomotor by the functionalization layer in a biologically active conformation, wherein the payload substance is attached to a portion of the functionalization layer or at least partially encapsulated within the functionalization layer, in which the nanomotor is operable to propel in a biological medium and into an intracellular region of a living cell to initiate an interaction of the biologically active payload substance with an intracellular constituent of the living cell.