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公开(公告)号：US20170342020A1
公开(公告)日：2017-11-30
申请号：US15614278
申请日：2017-06-05
发明人： Peter Walter , Carmela Sidrauski , Diego Acosta Alvear , Michelle R. Arkin , Christopher G. Wilson , Kean Hooi Ang , Brian R. Hearn , Punitha Vedantham , Adam R. Renslo , Mervyn Maze , Susana Vacas
IPC分类号： C07C235/14 , C07D495/04 , A61K31/165 , C07D403/12 , C07C323/60 , C07C317/44 , C07C317/22 , C07C271/52 , C07C271/24 , C07C257/14 , C07C255/54 , C07C235/24 , C07C235/22 , C07C235/20 , C07C211/29 , A61K31/4192 , C07F7/08 , C07C2601/14 , C07C2601/04
CPC分类号： C07C235/14 , A61K31/165 , A61K31/4192 , C07C211/29 , C07C235/20 , C07C235/22 , C07C235/24 , C07C255/54 , C07C257/14 , C07C271/24 , C07C271/52 , C07C317/22 , C07C317/44 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07D403/12 , C07D495/04 , C07F7/081
摘要： Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
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公开(公告)号：US11220477B2
公开(公告)日：2022-01-11
申请号：US16418858
申请日：2019-05-21
发明人： Peter Walter , Carmela Sidrauski , Diego Acosta Alvear , Michelle R. Arkin , Christopher G. Wilson , Kean Hooi Ang , Brian R. Hearn , Punitha Vedantham , Adam R. Renslo , Mervyn Maze , Susana Vacas
IPC分类号： C07C235/14 , C07F7/08 , A61K31/4192 , C07D403/12 , C07D495/04 , C07C255/54 , C07C257/14 , C07C271/24 , C07C271/52 , C07C211/29 , C07C317/22 , C07C317/44 , C07C323/60 , C07C235/20 , C07C235/22 , C07C235/24 , A61K31/165
摘要： Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
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公开(公告)号：US20160096800A1
公开(公告)日：2016-04-07
申请号：US14849428
申请日：2015-09-09
发明人： Peter Walter , Carmela Sidrauski , Diego Acosta Alvear , Michelle R. Arkin , Christopher G. Wilson , Kean Hooi Ang , Brian R. Hearn , Punitha Vedantham , Adam R. Renslo , Mervyn Maze , Susana Vacas
IPC分类号： C07C235/14
CPC分类号： C07C235/14 , A61K31/165 , A61K31/4192 , C07C211/29 , C07C235/20 , C07C235/22 , C07C235/24 , C07C255/54 , C07C257/14 , C07C271/24 , C07C271/52 , C07C317/22 , C07C317/44 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07D403/12 , C07D495/04 , C07F7/081
摘要： Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
摘要翻译： 本文提供了特别是用于调节eIF2α磷酸化，综合应激反应（ISR）和未折叠蛋白反应（UPR）的翻译效应的化合物和方法; 用于治疗疾病; 用于增加蛋白质生产和改善长期记忆。
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公开(公告)号：US10343981B2
公开(公告)日：2019-07-09
申请号：US15614278
申请日：2017-06-05
发明人： Peter Walter , Carmela Sidrauski , Diego Acosta Alvear , Michelle R. Arkin , Christopher G. Wilson , Kean Hooi Ang , Brian R. Hearn , Punitha Vedantham , Adam R. Renslo , Mervyn Maze , Susana Vacas
IPC分类号： C07C235/14 , C07C255/54 , C07C257/14 , C07C271/24 , C07C271/52 , C07C211/29 , C07C317/22 , C07C317/44 , C07C323/60 , C07C235/20 , C07C235/22 , C07C235/24 , C07D403/12 , C07D495/04 , C07F7/08 , A61K31/165 , A61K31/4192
摘要： Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
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公开(公告)号：US09708247B2
公开(公告)日：2017-07-18
申请号：US14849428
申请日：2015-09-09
发明人： Peter Walter , Carmela Sidrauski , Diego Acosta Alvear , Michelle R. Arkin , Christopher G. Wilson , Kean Hooi Ang , Brian R. Hearn , Punitha Vedantham , Adam R. Renslo , Mervyn Maze , Susana Vacas
IPC分类号： C07C235/14 , A61K31/165 , A61K31/4192 , C07D403/12 , C07D495/04 , C07C255/54 , C07C257/14 , C07C271/24 , C07C271/52 , C07C211/29 , C07C317/22 , C07C317/44 , C07C323/60 , C07C235/20 , C07C235/22 , C07C235/24 , C07F7/08
CPC分类号： C07C235/14 , A61K31/165 , A61K31/4192 , C07C211/29 , C07C235/20 , C07C235/22 , C07C235/24 , C07C255/54 , C07C257/14 , C07C271/24 , C07C271/52 , C07C317/22 , C07C317/44 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07D403/12 , C07D495/04 , C07F7/081
摘要： Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
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