公开(公告)号：US20240025895A1

公开(公告)日：2024-01-25

申请号：US18241583

申请日：2023-09-01

Applicant: The Regents of the University of California

Inventor： William E. Lowry ,  Michael E. Jung ,  Heather R. Christofk ,  Xiaoguang Liu ,  Aimee Flores

IPC: C07D471/04 ,  A61P17/14 ,  A61K9/00 ,  C07D209/22 ,  C07D413/06 ,  C07D417/06 ,  C07F9/535

CPC classification number: C07D471/04 ,  A61P17/14 ,  A61K9/0014 ,  C07F9/535 ,  C07D413/06 ,  C07D417/06 ,  C07D209/22

Abstract: The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

公开(公告)号：US20230365540A1

公开(公告)日：2023-11-16

申请号：US18025487

申请日：2021-09-09

Applicant: The Regents of the University of California

Inventor： Arjun Deb ,  Michael E. Jung ,  Xiaohong Chen ,  Shen Li ,  Yanpeng Xing ,  Hui Ding

IPC: C07D405/12 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D215/227 ,  C07D409/14 ,  C07D405/14 ,  C07C275/30 ,  C07C275/32 ,  C07C237/30 ,  C07D231/14

CPC classification number: C07D405/12 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D215/227 ,  C07D409/14 ,  C07D405/14 ,  C07C275/30 ,  C07C275/32 ,  C07C237/30 ,  C07D231/14

Abstract: The present disclosure relates to compounds that are capable of inhibiting the ENPP1 gene and treating a variety of cardiac conditions. The disclosure further relates to methods of treating or preventing cardiac conditions, such as myocardial infarction and heart failure.

公开(公告)号：US11787799B2

公开(公告)日：2023-10-17

申请号：US17342182

申请日：2021-06-08

Applicant: The Regents of the University of California

Inventor： Paul Krogstad ,  Michael E. Jung ,  Jun Zuo ,  Yanpeng Xing

IPC: C07D471/04 ,  A61P31/12 ,  A61P31/14

CPC classification number: C07D471/04 ,  A61P31/12 ,  A61P31/14

Abstract: The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.

公开(公告)号：US11771687B2

公开(公告)日：2023-10-03

申请号：US17093047

申请日：2020-11-09

Applicant: The Regents of the University of California

Inventor： Michael E. Jung ,  Charles L. Sawyers ,  Samedy Ouk ,  Chris Tran ,  John Wongvipat

IPC: A61K31/416 ,  A61K31/4439 ,  C07D401/04 ,  A61K9/48

CPC classification number: A61K31/4439 ,  A61K9/48 ,  C07D401/04

Abstract: Provided herein are hydantoin compounds useful for the prevention or treatment of hyperproliferative diseases or disorders. Exemplary hydantoin compounds include substituted diazaspiroalkanes, such as (A51) and (A52) having the following structures:

公开(公告)号：US11472804B2

公开(公告)日：2022-10-18

申请号：US17584091

申请日：2022-01-25

Applicant: The Regents of the University of California

Inventor： William E. Lowry ,  Michael E. Jung ,  Heather R. Christofk ,  Xiaoguang Liu ,  Aimee Flores

IPC: C07D471/04 ,  A61P17/14 ,  A61K9/00 ,  C07D209/22 ,  C07D413/06 ,  C07D417/06 ,  C07F9/535

Abstract: The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

公开(公告)号：US20210220331A1

公开(公告)日：2021-07-22

申请号：US16098784

申请日：2017-05-03

Applicant: The Regents of the University of California ,  The United State Government represented by the Department of Veterans Affairs

Inventor： Joseph F. Gera ,  Alan Lichtenstein ,  Michael E. Jung ,  Jihye Lee ,  Brent Holmes ,  Angelica Benavides-Serrato

IPC: A61K31/4015 ,  A61K31/436 ,  A61K31/519 ,  A61P35/00 ,  C07D207/456 ,  C07D207/452 ,  C07D209/48 ,  C07D207/448 ,  C07D239/54 ,  C07D217/24 ,  C07D239/96 ,  C07D237/32 ,  A61K31/502 ,  A61K31/4035 ,  A61K31/513

Abstract: This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

公开(公告)号：US20210121450A1

公开(公告)日：2021-04-29

申请号：US17093047

申请日：2020-11-09

Applicant: The Regents of the University of California

Inventor： Michael E. Jung ,  Charles L. Sawyers ,  Samedy Ouk ,  Chris Tran ,  John Wongvipat

IPC: A61K31/4439 ,  C07D401/04 ,  A61K9/48

Abstract: Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.

公开(公告)号：US20190292132A1

公开(公告)日：2019-09-26

申请号：US16304427

申请日：2017-05-26

Applicant: The Regents of the University of California

Inventor： John P. Chute ,  Michael E. Jung ,  Emelyne Diers

IPC: C07C225/16 ,  C07C311/39 ,  C07D307/52 ,  C07D317/66 ,  C07D231/12 ,  C07D333/22 ,  A61P7/06 ,  C07C225/22 ,  C07F7/18 ,  C07C233/31 ,  C07D211/58

Abstract: The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.

公开(公告)号：US20180318276A1

公开(公告)日：2018-11-08

申请号：US15969147

申请日：2018-05-02

Applicant: The Regents of the University of California

Inventor： Michael E. Jung ,  Charles L. Sawyers ,  Samedy Ouk ,  Chris Tran ,  John Wongvipat

IPC: A61K31/4439 ,  C07D401/04 ,  A61K9/48

CPC classification number: A61K31/4439 ,  A61K9/48 ,  C07D401/04

Abstract: Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.

公开(公告)号：US20180273527A1

公开(公告)日：2018-09-27

申请号：US15763073

申请日：2016-09-22

Applicant: The Regents of the University of California

Inventor： Paul Krogstad ,  Michael E. Jung ,  Jun Zuo ,  Yanpeng Xing

IPC: C07D471/04 ,  A61P31/12 ,  A61P31/14

CPC classification number: C07D471/04 ,  A61P31/12 ,  A61P31/14

Abstract: The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.