公开(公告)号：US20230372534A1

公开(公告)日：2023-11-23

申请号：US18053618

申请日：2022-11-08

Applicant: The Regents of the University of California

Inventor： Yuanpei LI ,  Xiangdong XUE ,  Yee HUANG ,  Zhao MA

IPC: A61K47/69 ,  G01N23/02 ,  A61K31/475 ,  A61K41/00 ,  A61K31/704 ,  A61K31/4965 ,  A61K31/337 ,  A61K31/417

CPC classification number: A61K47/6929 ,  G01N23/02 ,  A61K31/475 ,  A61K41/0033 ,  A61K31/704 ,  A61K31/4965 ,  A61K31/337 ,  A61K31/417

Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.

公开(公告)号：US20210138084A1

公开(公告)日：2021-05-13

申请号：US16622722

申请日：2018-06-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yuanpei LI ,  Xiangdong XUE ,  Yee HUANG ,  Zhao MA

IPC: A61K47/69 ,  A61K31/704 ,  G01N23/02 ,  A61K41/00 ,  A61K31/4965 ,  A61K31/337 ,  A61K31/417 ,  A61K31/475

Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.

公开(公告)号：US20230348419A1

公开(公告)日：2023-11-02

申请号：US17761162

申请日：2020-09-18

Applicant: The Regents of the University of California

Inventor： Yuanpei LI ,  Zhao MA

IPC: C07D401/12 ,  A61K45/06 ,  A61K51/12 ,  C07J43/00 ,  C07D401/14 ,  C07D487/22 ,  B82Y30/00 ,  B82Y5/00

CPC classification number: C07D401/12 ,  A61K45/06 ,  A61K51/1251 ,  C07J43/003 ,  C07D401/14 ,  C07D487/22 ,  B82Y30/00 ,  B82Y5/00

Abstract: The present invention provides bisaminoquinoline compounds of Formula (I). The present invention also provides nanocarriers comprising compounds of the present invention, and methods of using the nanocarriers for treating diseases and imaging.