公开(公告)号：US11571538B2

公开(公告)日：2023-02-07

申请号：US16603169

申请日：2018-04-11

Applicant: The Regents of the University of Michigan

Inventor： Mark E. Meyerhoff ,  Nicolai Lehnert ,  Yu Qin ,  Andrew Hunt ,  Elizabeth J. Brisbois ,  Hang Ren

IPC: A61M16/12 ,  A61M16/08 ,  A61M16/10 ,  A61M1/16 ,  A61M1/34 ,  A61M25/00 ,  A61K33/00 ,  A61M35/00

Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.