公开(公告)号：US20220218880A1

公开(公告)日：2022-07-14

申请号：US17617507

申请日：2020-06-09

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Maria Kim ,  Elizabeth J. Brisbois ,  Joshua C. Doverspike ,  Shale J. Mack ,  Orsolya I. Lautner-Csorba ,  Kamila Katarzyna Konopinska ,  Mark E. Meyerhoff

IPC分类号： A61L29/16 ,  A61M25/00 ,  A61L29/06 ,  A61L29/02

摘要： A catheter insert device includes a powder composition, and a housing. The powder composition includes a solid phase S-nitrosothiol (RSNO). The housing includes a polymeric wall that is i) permeable to nitric oxide, ii) non-porous, and iii) permeable to water vapor, and an inner lumen defined at least in part by the polymeric wall. The powder composition is completely sealed within the inner lumen of the housing.

公开(公告)号：US20220111173A1

公开(公告)日：2022-04-14

申请号：US17279448

申请日：2019-09-27

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Gergely Lautner ,  Blake Stringer ,  Elizabeth J. Brisbois ,  Mark E. Meyerhoff ,  Steven P. Schwendeman

IPC分类号： A61M16/12 ,  A61M16/10 ,  A61M16/00 ,  A61M15/00

摘要： Gas delivery devices include different examples of nitric oxide (NO) generating systems. Each example of the NO generating system includes a solid, light sensitive NO donor, and a light source that is operatively positioned to selectively expose the solid, light sensitive NO donor to light in order to generate NO gas.

公开(公告)号：US20160339154A1

公开(公告)日：2016-11-24

申请号：US15113940

申请日：2015-01-27

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Xiangfeng Duan ,  Yu Huang ,  Teng Xue ,  Mark E. Meyerhoff

IPC分类号： A61L33/02 ,  B01J31/18 ,  C12N11/14 ,  A61L27/54 ,  A61L31/08 ,  A61L31/16 ,  A61L27/30 ,  B01J31/00 ,  A61L33/00

CPC分类号： A61L33/025 ,  A61L27/303 ,  A61L27/54 ,  A61L31/084 ,  A61L31/16 ,  A61L33/0041 ,  A61L33/0047 ,  A61L33/0082 ,  B01J21/18 ,  B01J31/003 ,  B01J31/1616 ,  B01J31/1815 ,  B01J31/183 ,  B01J2231/70 ,  B01J2531/025 ,  C12N11/14 ,  C12Y101/03004

摘要： Described here is a graphene-catalysts conjugate, comprising: a graphene support; a first catalyst conjugated to the graphene support; and a second catalyst conjugated to the graphene support, and the second catalyst is different from the first catalyst. In some embodiments, the first catalyst and the second catalyst correspond to a tandem catalytic system to drive a chemical transformation.

摘要翻译： 这里描述的是石墨烯 - 催化剂缀合物，其包括：石墨烯载体; 与石墨烯载体共轭的第一催化剂; 和与石墨烯载体共轭的第二催化剂，第二催化剂与第一催化剂不同。 在一些实施方案中，第一催化剂和第二催化剂对应于驱动化学转化的串联催化体系。

公开(公告)号：US09498571B2

公开(公告)日：2016-11-22

申请号：US13852841

申请日：2013-03-28

申请人： The Regents of the University of Michigan

发明人： Lajos Hofler ,  Mark E. Meyerhoff ,  Dipankar Koley

IPC分类号： A61M5/14 ,  A61M25/00 ,  A61K33/00 ,  C01B21/24

CPC分类号： A61M5/14 ,  A61K33/00 ,  A61M25/00 ,  A61M25/0043 ,  A61M2025/0057 ,  A61M2202/0275 ,  A61M2205/0233 ,  A61M2205/0272 ,  C01B21/24

摘要： A nitric oxide delivery device includes a housing that is permeable to nitric oxide. The surface of the housing is modified to detect surface charge or pH (e.g., due to cell adhesion). A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A reference/counter electrode is also positioned inside of the housing, and is electrically isolated from the working electrode. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.

摘要翻译： 一氧化氮递送装置包括可渗透一氧化氮的壳体。 修改壳体的表面以检测表面电荷或pH（例如，由于细胞粘附）。 工作电极（其是含铜导电材料或涂覆有含铜导电材料的基材）位于壳体内部。 参考/对电极也位于壳体的内部，并且与工作电极电隔离。 亚硝酸根离子源将被包含在壳体内，使其与工作电极接触。

公开(公告)号：US20140294672A1

公开(公告)日：2014-10-02

申请号：US14099942

申请日：2013-12-07

申请人： The Regents of the University of Michigan

发明人： Mark E. Meyerhoff ,  Lajos Hofler ,  Dipankar Koley ,  Hang Ren

IPC分类号： A61M1/34 ,  A61M16/12 ,  A61M1/16

CPC分类号： A61M16/12 ,  A61K33/00 ,  A61M1/1698 ,  A61M1/342 ,  A61M1/3462 ,  A61M25/0043 ,  A61M35/00 ,  A61M2025/0057 ,  A61M2202/0208 ,  A61M2202/0275

摘要： An example of a nitric oxide delivery device includes a medium, a working electrode in contact with the medium, and a reference/counter electrode in contact with the medium and electrically isolated from the working electrode. The medium includes a source of nitrite ions and a Cu(II)-ligand complex. A nitric oxide permeable material separates the medium from an external environment that is to contain blood.

摘要翻译： 一氧化氮递送装置的实例包括介质，与介质接触的工作电极，以及与介质接触并与工作电极电隔离的参考/对电极。 介质包括亚硝酸根离子源和Cu（II）配位体。 一氧化氮可渗透材料将介质与包含血液的外部环境分开。

公开(公告)号：US20130261537A1

公开(公告)日：2013-10-03

申请号：US13852841

申请日：2013-03-28

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Lajos Hofler ,  Mark E. Meyerhoff ,  Dipankar Koley

IPC分类号： A61M25/00 ,  A61K33/00

CPC分类号： A61M5/14 ,  A61K33/00 ,  A61M25/00 ,  A61M25/0043 ,  A61M2025/0057 ,  A61M2202/0275 ,  A61M2205/0233 ,  A61M2205/0272 ,  C01B21/24

摘要： A nitric oxide delivery device includes a housing that is permeable to nitric oxide. The surface of the housing is modified to detect surface charge or pH (e.g., due to cell adhesion). A working electrode (which is a copper-containing conductive material or a base material coated with a copper-containing conductive material) is positioned inside of the housing. A reference/counter electrode is also positioned inside of the housing, and is electrically isolated from the working electrode. A source of nitrite ions is to be contained within the housing such that it is in contact with the working electrode.

摘要翻译： 一氧化氮递送装置包括可渗透一氧化氮的壳体。 修改壳体的表面以检测表面电荷或pH（例如，由于细胞粘附）。 工作电极（其是含铜导电材料或涂覆有含铜导电材料的基材）位于壳体内部。 参考/对电极也位于壳体的内部，并且与工作电极电隔离。 亚硝酸根离子源将被包含在壳体内，使其与工作电极接触。

公开(公告)号：US11998513B2

公开(公告)日：2024-06-04

申请号：US16976382

申请日：2019-02-28

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Joshua C. Doverspike ,  James Phan ,  Jianfeng Wu ,  Chuanwu Xi ,  Yu Qin ,  Mark E. Meyerhoff ,  Yang Zhou

IPC分类号： A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/06 ,  A61K47/06 ,  B01J23/72 ,  B01J31/02 ,  A61K9/00 ,  A61K9/06

CPC分类号： A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/063 ,  A61K47/06 ,  B01J23/72 ,  B01J31/0272 ,  A61K9/0014 ,  A61K9/06

摘要： A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

公开(公告)号：US11413420B2

公开(公告)日：2022-08-16

申请号：US16752159

申请日：2020-01-24

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Mark E. Meyerhoff ,  Lajos Hofler ,  Dipankar Koley ,  Hang Ren

IPC分类号： A61M16/12 ,  A61M1/34 ,  A61M1/16 ,  A61M25/00 ,  A61K33/00 ,  A61M35/00

摘要： A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.

公开(公告)号：US10543337B2

公开(公告)日：2020-01-28

申请号：US15226769

申请日：2016-08-02

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Mark E. Meyerhoff ,  Lajos Hofler ,  Dipankar Koley ,  Hang Ren

IPC分类号： A61M16/12 ,  A61M1/34 ,  A61M1/16 ,  A61M25/00 ,  A61K33/00 ,  A61M35/00

摘要： A gas delivery device includes a nitric oxide generating system. The system has a medium including i) a source of nitrite ions, or ii) a source of nitrite ions and a Cu(II)-ligand complex. A working electrode is in contact with the medium, wherein i) when the medium includes the source of nitrite ions, the working electrode is a copper containing conductive material or a base material coated with a copper containing conductive material, or ii) when the medium includes the source of nitrite ions and the Cu(II)-ligand complex, the working electrode is platinum, gold, carbon, a carbon coated material, and/or mercury. A reference/counter electrode is in contact with the medium and electrically isolated from the working electrode. An inlet conduit is to deliver oxygen gas to the medium, and an outlet conduit is to transport a stream of oxygen gas and nitric oxide from the medium.

公开(公告)号：US20190307710A1

公开(公告)日：2019-10-10

申请号：US15735122

申请日：2016-06-10

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Gergely Lautner ,  Steven P. Schwendeman ,  Mark E. Meyerhoff

IPC分类号： A61K31/19 ,  A61K47/36 ,  A61K9/00 ,  A61K9/06 ,  A61L15/28 ,  A61L15/52

摘要： A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.