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1.发明授权Sustained nitric oxide release coating using diazeniumdiolate-doped polymer matrix with ester capped poly(lactic-co-glycolic acid) additive 有权使用掺二氮烯二恶英掺杂聚合物基质和酯封端聚（乳酸 - 乙醇酸）添加剂的持续一氧化氮释放涂层公开(公告)号：US09566372B2
公开(公告)日：2017-02-14
申请号：US14430545
申请日：2013-09-25
发明人： Hitesh Handa , Mark E. Meyerhoff , Robert H. Bartlett , Elizabeth J. Brisbois , Lahdan Refahiyat
IPC分类号： A61L31/16 , C08L27/06 , C08G18/61 , A61L29/04 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/14
CPC分类号： A61L31/16 , A61L29/049 , A61L29/141 , A61L29/16 , A61L31/041 , A61L31/141 , A61L2300/114 , A61L2300/802 , C08G18/61 , C08K5/32 , C08L27/06 , C08L67/04 , C08L83/04
摘要： A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.
摘要翻译： 聚合物组合物包括具有亲脂性离散一氧化氮加合物和/或与其相关的聚合一氧化氮加合物的聚合物基质，通过共价连接到聚合物基质和/或通过聚合物基质内的分散体与离散的一氧化氮加合物和/ 或能够释放一氧化氮（NO）的聚合一氧化氮加合物。 所述聚合物组合物还包含酯封端的聚（丙交酯 - 共 - 乙交酯）（PLGA）添加剂，用于增加，延长和控制来自亲脂性离散一氧化氮加合物和/或聚合一氧化氮加合物的NO释放速率中的至少一种。
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2.发明申请SUSTAINED NITRIC OXIDE RELEASE COATING USING DIAZENIUMDIOLATE-DOPED POLYMER MATRIX WITH ESTER CAPPED POLY(LACTIC-CO-GLYCOLIC ACID) ADDITIVE 有权使用具有ESTER CAPPED POLY（LACTIC-CO-GLYCOLIC ACID）添加剂的DIAZENIUMPOLATE-DOPED POLYMER MATRIX的持久氮氧化物涂层公开(公告)号：US20150238662A1
公开(公告)日：2015-08-27
申请号：US14430545
申请日：2013-09-25
发明人： Hitesh Handa , Mark E. Meyerhoff , Robert H. Bartlett , Elizabeth J. Brisbois , Lahdan Refahiyat
CPC分类号： A61L31/16 , A61L29/049 , A61L29/141 , A61L29/16 , A61L31/041 , A61L31/141 , A61L2300/114 , A61L2300/802 , C08G18/61 , C08K5/32 , C08L27/06 , C08L67/04 , C08L83/04
摘要： A polymeric composition includes a polymer matrix having a lipophilic discrete nitric oxide adduct and/or a polymeric nitric oxide adduct associated therewith, by covalent attachment to the polymer matrix and/or by dispersion within the polymer matrix, with the discrete nitric oxide adduct and/or the polymeric nitric oxide adduct being capable of releasing nitric oxide (NO). The polymeric composition further includes an ester capped poly(lactide-co-glycolide) (PLGA) additive to at least one of increase, prolong, and control NO release rates from the lipophilic discrete nitric oxide adduct and/or the polymeric nitric oxide adduct.
摘要翻译： 聚合物组合物包括具有亲脂性离散一氧化氮加合物和/或与其相关的聚合一氧化氮加合物的聚合物基质，通过共价连接到聚合物基质和/或通过聚合物基质内的分散体与离散的一氧化氮加合物和/ 或能够释放一氧化氮（NO）的聚合一氧化氮加合物。 所述聚合物组合物还包含酯封端的聚（丙交酯 - 共 - 乙交酯）（PLGA）添加剂，用于增加，延长和控制来自亲脂性离散一氧化氮加合物和/或聚合一氧化氮加合物的NO释放速率中的至少一种。
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