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公开(公告)号：US20190169235A1
公开(公告)日：2019-06-06
申请号：US15773685
申请日：2016-11-07
发明人： Bruce Futcher , Justin Gardin , Steven Skiena , Alisa Yurovsky , Eckard Wimmer , Steffen Mueller
IPC分类号： C07K14/005 , C12N7/00
摘要： This invention provides a modified protein encoding sequence containing nucleotide substitutions at multiple locations in the protein encoding sequence, wherein the substitutions introduce rare hexamers. These hexamers may be Frame Dependent, or depleted in only the reading frame, or Frame Independent, or depleted in all three frames. Modified protein encoding se quences of the present invention may include modified viruses useful for vaccines.
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2.发明授权公开(公告)号：US09957486B2
公开(公告)日：2018-05-01
申请号：US14766620
申请日：2014-02-07
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , The Research Foundation for the State University of New York
发明人： Peter L. Collins , Cyril Le Nouën , Linda G. Brock , Ursula J. Buchholz , Joshua Marc DiNapoli , Steffen Mueller , Eckard Wimmer
IPC分类号： C12N7/00 , A61K39/155 , C07K14/005 , A61K39/00
CPC分类号： C12N7/00 , A61K39/155 , A61K2039/5254 , A61K2039/53 , A61K2039/55 , C07K14/005 , C12N2760/00021 , C12N2760/00034 , C12N2760/00062 , C12N2760/18522 , C12N2760/18534 , C12N2760/18561 , C12N2760/18562
摘要： Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
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公开(公告)号：US20170067030A1
公开(公告)日：2017-03-09
申请号：US15258584
申请日：2016-09-07
发明人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
IPC分类号： C12N7/00 , A61K39/13 , A61K39/145 , C07K14/005
CPC分类号： C12N7/00 , A61K39/13 , A61K39/145 , A61K2039/5254 , C07K14/005 , C12N2720/12361 , C12N2740/15061 , C12N2760/16061 , C12N2760/16121 , C12N2760/16134 , C12N2760/16162 , C12N2770/20061 , C12N2770/24161 , C12N2770/32061 , C12N2770/32621 , C12N2770/32634 , C12N2770/32661 , C12N2770/32662 , C12N2770/32671 , C12N2770/32721 , C12N2770/32761 , C12N2770/32762 , Y02A50/386 , Y02A50/388 , Y02A50/466
摘要： This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.
摘要翻译： 本发明提供了一种减毒病毒，其包含经修饰的病毒基因组，其含有在基因组中多个位置工程改造的核苷酸取代，其中所述取代引入同义脱酮密码子进入基因组。 本发明的减毒病毒可用于疫苗组合物中以在受试者中诱导保护性免疫应答。 本发明还提供了合成即时减毒病毒的方法。 此外，本发明进一步提供了一种防止受试者患有病毒相关疾病的方法，包括向受试者施用预防有效剂量的包含即时减毒病毒的疫苗组合物。
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公开(公告)号：US10316294B2
公开(公告)日：2019-06-11
申请号：US14777204
申请日：2014-03-15
发明人： Steffen Mueller , Eckard Wimmer , Bruce Futcher , Steven Skiena , Chen Yang
IPC分类号： C12N7/00 , A61K39/145
摘要： This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.
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公开(公告)号：US10023845B2
公开(公告)日：2018-07-17
申请号：US15258584
申请日：2016-09-07
发明人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
IPC分类号： C12N7/00 , A61K39/13 , A61K39/145 , C07K14/005 , A61K39/00
摘要： This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.
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6.发明授权公开(公告)号：US12054749B2
公开(公告)日：2024-08-06
申请号：US17831259
申请日：2022-06-02
申请人： The United States of America, as Represented by the Secretary, Department of Health & Human Services , The Research Foundation for the State University of New York
发明人： Peter L. Collins , Cyril Le Nouen , Linda G. Brock , Ursula J. Buchholz , Joshua Marc Dinapoli , Steffen Mueller , Eckard Wimmer
IPC分类号： C12N7/00 , A61K39/155 , C07K14/005 , A61K39/00
CPC分类号： C12N7/00 , A61K39/155 , C07K14/005 , A61K2039/5254 , A61K2039/53 , A61K2039/55 , C12N2760/00021 , C12N2760/00034 , C12N2760/00062 , C12N2760/18522 , C12N2760/18534 , C12N2760/18561 , C12N2760/18562
摘要： Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
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7.发明授权公开(公告)号：US11371024B2
公开(公告)日：2022-06-28
申请号：US15924012
申请日：2018-03-16
申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services , The Research Foundation for the State University of New York
发明人： Peter L. Collins , Cyril Le Nouën , Linda G. Brock , Ursula J. Buchholz , Joshua Marc DiNapoli , Steffen Mueller , Eckard Wimmer
IPC分类号： C12N7/00 , A61K39/155 , C07K14/005 , A61K39/00
摘要： Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
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公开(公告)号：US10400220B2
公开(公告)日：2019-09-03
申请号：US15508695
申请日：2015-09-08
发明人： Eckard Wimmer , Steffen Mueller , Bruce Futcher , Sam Shen , Charles Stauft , Charles Ward
摘要： This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.
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公开(公告)号：US20190002837A1
公开(公告)日：2019-01-03
申请号：US15508695
申请日：2015-09-08
发明人： Eckard Wimmer , Steffen Mueller , Bruce Futcher , Sam Shen , Charles Stauft , Charles Ward
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , C12N7/04 , C12N2760/12221 , C12N2760/12233 , C12N2760/12234 , C12N2760/12262 , C12N2760/20062 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , C12N2800/22 , Y02A50/386
摘要： This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.
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10.发明申请公开(公告)号：US20180208906A1
公开(公告)日：2018-07-26
申请号：US15924012
申请日：2018-03-16
申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services , The Research Foundation for the State University of New York
发明人： Peter L. Collins , Cyril Le Nouën , Linda G. Brock , Ursula J. Buchholz , Joshua Marc DiNapoli , Steffen Mueller , Eckard Wimmer
IPC分类号： C12N7/00 , A61K39/155 , C07K14/005 , A61K39/00
CPC分类号： C12N7/00 , A61K39/155 , A61K2039/5254 , A61K2039/53 , A61K2039/55 , C07K14/005 , C12N2760/00021 , C12N2760/00034 , C12N2760/00062 , C12N2760/18522 , C12N2760/18534 , C12N2760/18561 , C12N2760/18562
摘要： Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
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