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    Methods, Devices And Formulations For Targeted Endobronchial Therapy
    1.
    发明申请
    Methods, Devices And Formulations For Targeted Endobronchial Therapy 审中-公开
    方法，用于靶向支气管理的装置和制剂

    公开(公告)号：US20140053830A1

    公开(公告)日：2014-02-27

    申请号：US13967639

    申请日：2013-08-15

    申请人： The Research Foundation of State University of New York

    发明人： Gerald C. Smaldone ,  Lucy B. Palmer

    IPC分类号： A61M15/00

    CPC分类号： A61M15/009 ,  A61M11/00 ,  A61M11/06 ,  A61M16/0057 ,  A61M16/04 ,  A61M16/0463 ,  A61M16/0465 ,  A61M16/0484 ,  A61M16/08 ,  A61M16/0808 ,  A61M16/0833

    摘要： The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

    摘要翻译： 本发明提供了一种在医院病人中治疗气管支气管炎，支气管扩张和肺炎的改进方法，优选以气雾剂化的抗革兰氏阳性和抗革兰氏阴性抗生素联合给药或以可靠的足量施用治疗效果。 一方面，当将气溶胶输送到呼吸机回路中时，本发明保证了这一结果。 在一个实施例中，结果是机械地实现的。 在另一个实施方案中，结果是通过气溶胶制剂实现的。 另一方面，本发明确保将气溶胶直接输送到呼吸机回路远端的气道时的结果。 治疗手段消除了通过呼吸机电路引入气溶胶时通气机系统产生的剂量变异性。 治疗方法还将治疗剂特异性地浓缩在肺中的受影响部位，使得治疗水平的给药药物在没有患者体内暴露于药物的情况下实现。 本发明还提供了一种用于控制该专门方案的剂量控制装置。

    Methods, Devices And Formulations For Targeted Endobronchial Therapy
    3.
    发明申请
    Methods, Devices And Formulations For Targeted Endobronchial Therapy 有权
    方法，用于靶向支气管理的装置和制剂

    公开(公告)号：US20130298904A1

    公开(公告)日：2013-11-14

    申请号：US13932757

    申请日：2013-07-01

    申请人： The Research Foundation of State University of New York

    发明人： Gerald C. Smaldone ,  Lucy B. Palmer

    IPC分类号： A61M11/00 ,  A61M16/04 ,  A61M16/00

    CPC分类号： A61M15/009 ,  A61M11/00 ,  A61M11/06 ,  A61M16/0057 ,  A61M16/04 ,  A61M16/0463 ,  A61M16/0465 ,  A61M16/0484 ,  A61M16/08 ,  A61M16/0808 ,  A61M16/0833

    摘要： The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

    摘要翻译： 本发明提供了一种在医院病人中治疗气管支气管炎，支气管扩张和肺炎的改进方法，优选以气雾剂化的抗革兰氏阳性和抗革兰氏阴性抗生素联合给药或以可靠的足量施用治疗效果。 一方面，当将气溶胶输送到呼吸机回路中时，本发明保证了这一结果。 在一个实施例中，结果是机械地实现的。 在另一个实施方案中，结果是通过气溶胶制剂实现的。 另一方面，本发明确保将气溶胶直接输送到呼吸机回路远端的气道时的结果。 治疗手段消除了通过呼吸机电路引入气溶胶时通气机系统产生的剂量变异性。 治疗方法还将治疗剂特异性地浓缩在肺中的受影响部位，使得治疗水平的给药药物在没有患者体内暴露于药物的情况下实现。 本发明还提供了一种用于控制该专门方案的剂量控制装置。