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公开(公告)号：US11377496B2
公开(公告)日：2022-07-05
申请号：US16420062
申请日：2019-05-22
发明人： Chanhyuk Kim , Jun Y. Axup , Hwayoung Yun , Peter G. Schultz , Jennifer Ma , Jiayin Shen , Pengyu Yang
IPC分类号： C07K16/28 , A61K47/54 , C07K16/32 , C07K16/46 , A61K39/395 , C07C275/16 , C07C275/24 , C07D249/04 , C07K16/30 , A61K39/00
摘要： Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.
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公开(公告)号：US10039809B2
公开(公告)日：2018-08-07
申请号：US15104807
申请日：2014-12-17
发明人： Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
IPC分类号： A61K31/23 , A61K31/20 , A61K47/48 , A61K47/30 , A61K38/22 , A61K9/00 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/54 , A61K9/70
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
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公开(公告)号：US10010589B2
公开(公告)日：2018-07-03
申请号：US15104807
申请日：2014-12-17
发明人： Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
IPC分类号： A61K31/23 , A61K31/20 , A61K47/48 , A61K47/30 , A61K38/22 , A61K9/00 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/54 , A61K9/70
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
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公开(公告)号：US11865160B2
公开(公告)日：2024-01-09
申请号：US17317631
申请日：2021-05-11
发明人： Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
IPC分类号： A61K38/22 , A61K31/20 , A61K38/48 , A61K47/30 , A61K9/00 , A61K47/60 , A61K47/54 , A61K38/26 , A61K45/06 , A61K9/70
CPC分类号： A61K38/22 , A61K9/0019 , A61K9/0021 , A61K38/2278 , A61K38/26 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/554 , A61K47/60 , A61K9/703
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
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公开(公告)号：US11007252B2
公开(公告)日：2021-05-18
申请号：US16000829
申请日：2018-06-05
发明人： Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
IPC分类号： A61K38/22 , A61K31/20 , A61K47/48 , A61K47/30 , A61K9/00 , A61K47/60 , A61K47/54 , A61K38/26 , A61K45/06 , A61K9/70
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
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公开(公告)号：US10286078B2
公开(公告)日：2019-05-14
申请号：US14917689
申请日：2014-09-12
发明人： Weijun Shen , Peter G. Schultz , Avinash Muppidi , Insha Ahmad , Pengyu Yang
IPC分类号： A61K38/22 , A61K9/00 , A61K47/48 , A61K38/26 , A61K38/28 , A61K38/17 , A61K38/18 , A61K45/06 , A61K47/54
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. One or more half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents (mTAs) comprising one or more half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.
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公开(公告)号：US10987427B2
公开(公告)日：2021-04-27
申请号：US16405594
申请日：2019-05-07
发明人： Weijun Shen , Peter G. Schultz , Avinash Muppidi , Insha Ahmad , Pengyu Yang
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. One or more half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents (mTAs) comprising one or more half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.
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8.发明申请公开(公告)号：US20180344812A1
公开(公告)日：2018-12-06
申请号：US16000829
申请日：2018-06-05
发明人： Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
CPC分类号： A61K38/22 , A61K9/0019 , A61K9/0021 , A61K9/703 , A61K38/2278 , A61K38/26 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/554 , A61K47/60
摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
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9.发明公开公开(公告)号：US20240148747A1
公开(公告)日：2024-05-09
申请号：US18546217
申请日：2022-02-11
发明人： Michael J. Bollong , Peter G. Schultz , Arnab Chatterjee , Weijun Shen , Elshan Nakath G. Ralalage , Edyta M. Grzelak , Pengyu Yang
IPC分类号： A61K31/551 , A61K31/4155 , A61K31/416 , A61K31/4192 , A61K31/422 , A61K31/423 , A61K31/424 , A61K31/427 , A61K31/437 , A61K31/4427 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P17/02
CPC分类号： A61K31/551 , A61K31/4155 , A61K31/416 , A61K31/4192 , A61K31/422 , A61K31/423 , A61K31/424 , A61K31/427 , A61K31/437 , A61K31/4427 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P17/02
摘要： The present disclosure provides compounds, or their tautomers or pharmaceutically acceptable salts thereof, and their pharmaceutical compositions that can selectively activate Yes-associated protein 1 (YAP). YAP activators of the present disclosure are useful in therapies such as wound and organ repair including, for example, treatment of chronic ulcers.
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公开(公告)号：US10351626B2
公开(公告)日：2019-07-16
申请号：US14774647
申请日：2014-03-14
发明人： Chanhyuk Kim , Jun Y. Axup , Hwayoung Yun , Peter G. Schultz , Jennifer Ma , Jiayin Shen , Pengyu Yang
IPC分类号： A61K47/68 , C07K16/28 , C07K16/32 , C07K16/46 , A61K39/395 , C07C275/16 , C07C275/24 , C07D249/04 , C07K16/30 , A61K47/54 , A61K39/00
摘要： Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.
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