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公开(公告)号：US20180104354A1
公开(公告)日：2018-04-19
申请号：US15644657
申请日：2017-07-07
发明人： Chanhyuk Kim , Travis Young , Yu Cao , Jennifer Ma , Minsoo Kim , Stephanie A. Pinkerton , Peter G. Schultz
IPC分类号： C07K16/28 , A61K31/4188 , A61K39/385 , C07K16/44 , C07K16/40 , C07K16/32 , A61K31/352 , A61K49/00 , A61K39/395
CPC分类号： A61K47/6849 , A61K31/352 , A61K31/4188 , A61K39/385 , A61K39/3955 , A61K47/6835 , A61K49/0041 , A61K49/0058 , C07K16/2803 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/40 , C07K16/44 , C07K2317/522 , C07K2317/567 , C07K2317/622
摘要： Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.
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公开(公告)号：US10351626B2
公开(公告)日：2019-07-16
申请号：US14774647
申请日：2014-03-14
发明人： Chanhyuk Kim , Jun Y. Axup , Hwayoung Yun , Peter G. Schultz , Jennifer Ma , Jiayin Shen , Pengyu Yang
IPC分类号： A61K47/68 , C07K16/28 , C07K16/32 , C07K16/46 , A61K39/395 , C07C275/16 , C07C275/24 , C07D249/04 , C07K16/30 , A61K47/54 , A61K39/00
摘要： Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.
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公开(公告)号：US09624276B2
公开(公告)日：2017-04-18
申请号：US14688894
申请日：2015-04-16
发明人： Travis Young , Chanhyuk Kim , Peter G. Schultz
IPC分类号： C07K14/395 , C07K14/00 , C07K16/00 , A61K39/00 , C12N5/10 , C07K19/00 , C12N5/0783 , A61K38/00
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/3955 , A61K2039/505 , A61K2039/515 , A61K2039/572 , A61K2039/70 , C07K14/395 , C07K16/2803 , C07K16/2887 , C07K2319/01 , C07K2319/30 , C12N5/0636
摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
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公开(公告)号：US11377496B2
公开(公告)日：2022-07-05
申请号：US16420062
申请日：2019-05-22
发明人： Chanhyuk Kim , Jun Y. Axup , Hwayoung Yun , Peter G. Schultz , Jennifer Ma , Jiayin Shen , Pengyu Yang
IPC分类号： C07K16/28 , A61K47/54 , C07K16/32 , C07K16/46 , A61K39/395 , C07C275/16 , C07C275/24 , C07D249/04 , C07K16/30 , A61K39/00
摘要： Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.
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公开(公告)号：US11091546B2
公开(公告)日：2021-08-17
申请号：US15566680
申请日：2016-04-15
发明人： Travis Young , David T. Rodgers , Ian Hardy , Chanhyuk Kim , Peter G. Schultz , Eric Hampton , Eduardo Laborda , Leonard Presta
摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
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公开(公告)号：US10391155B2
公开(公告)日：2019-08-27
申请号：US15448477
申请日：2017-03-02
发明人： Travis Young , Chanhyuk Kim , Peter G. Schultz
IPC分类号： A61K39/00 , C07K16/28 , A61K39/395 , C12N5/0783 , C07K14/00 , C07K14/395 , C07K16/00 , C12N5/10 , C07K19/00 , A61K38/00
摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
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7.发明授权公开(公告)号：US10800828B2
公开(公告)日：2020-10-13
申请号：US15561274
申请日：2016-03-28
发明人： Travis Young , Chanhyuk Kim , Peter G. Schultz
IPC分类号： C07K14/705 , C07K7/08 , C07K14/47 , A61K38/00 , C12N9/12 , A61K48/00 , C07K14/725 , A61P35/00 , C07K14/195 , C07K14/32 , C07K14/78 , C12N5/0783 , C12N9/22
摘要： Disclosed herein are switchable chimeric receptors, switchable chimeric receptor effector cells and chimeric receptor effector cell switches. The switchable chimeric receptor-ECs are generally T cells. The chimeric receptors have non-antibody extracellular domains that recognize a chimeric receptor binding partner on the chimeric receptor-EC switch or target cell. The chimeric receptor-ECs and switches may be used for the treatment of a disease or condition in a subject in need thereof.
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公开(公告)号：US20230355728A1
公开(公告)日：2023-11-09
申请号：US18056554
申请日：2022-11-17
发明人： Travis Young , Chanhyuk Kim , Peter G. Schultz
IPC分类号： C12N5/0783 , C07K14/395 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： A61K39/0002 , A61K39/3955 , C07K14/395 , C07K16/2803 , C07K16/2887 , C12N5/0636 , A61K38/00
摘要： Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
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