公开(公告)号：US20230340599A1

公开(公告)日：2023-10-26

申请号：US18245957

申请日：2021-09-15

Applicant: The Secretary of State for Defence

Inventor： Roman Antoni Lukaszewski ,  Ioannis Panagiotou ,  Wolfgang Schmidt-Heck

IPC: C12Q1/6883 ,  C12Q1/6837

CPC classification number: C12Q1/6883 ,  C12Q1/6837 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The present invention is concerned with kits, methods and apparatus for analysing a biological sample from a subject to predict and/or monitor the development of infection and/or organ dysfunction and/or sepsis utilising groups of nucleic acid markers to predict the development of infection and/or organ dysfunction and/or sepsis.

公开(公告)号：US10597720B2

公开(公告)日：2020-03-24

申请号：US15117923

申请日：2015-01-09

Applicant: THE SECRETARY OF STATE FOR DEFENCE

Inventor： Phillippa Maria Spencer ,  Roman Antoni Lukaszewski ,  Laura Craddock ,  Helen Eleri Jones

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6883 ,  G16B25/00

Abstract: The present invention provides kits, methods, and apparatus for analysing a biological sample from an animal to predict (pre-symptomatically) and monitor the development of sepsis, utilising biomarker signatures, and especially biomarker signatures capable of providing a mean predictive accuracy of at least 92% to differentiate development of sepsis from non-sepsis.

公开(公告)号：US20230348976A1

公开(公告)日：2023-11-02

申请号：US18245685

申请日：2021-09-15

Applicant: The Secretary of State for Defence

Inventor： Roman Antoni Lukaszewski ,  Ioannis Panagiotou ,  Wolfgang Schmidt-Heck

IPC: C12Q1/6876

CPC classification number: C12Q1/6876 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/50

Abstract: The present invention is concerned with kits, methods and apparatus for analysing a biological sample from a subject to predict and/or monitor the development of infection and/or organ dysfunction and/or sepsis utilising groups of nucleic acid markers to predict the development of infection and/or organ dysfunction and/or sepsis.

公开(公告)号：US20230228765A1

公开(公告)日：2023-07-20

申请号：US18001291

申请日：2021-06-17

Applicant: The Secretary of State for Defence

Inventor： Thomas Robert Laws ,  Roman Antoni Lukaszewski

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2800/26 ,  G01N2800/52

Abstract: The invention relates to protein biomarkers representing protein biomarker signatures to assess a patient who may develop sepsis, or who may have developed sepsis. The invention relates in particular to methods for assessment or monitoring with respect to diagnosis, prediction or progression of sepsis in a patient, as well as the responsiveness to, or selection of suitable agents for, the treatment of sepsis. The invention also relates to the use of protein biomarkers representing protein biomarker signatures for sepsis, and associated kits and system.