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    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
    2.
    发明申请
    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF 有权

    公开(公告)号：US20210130349A1

    公开(公告)日：2021-05-06

    申请号：US17137665

    申请日：2020-12-30

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Donald W. LANDRY ,  Shixian DENG ,  Ottavio ARANCIO ,  Jole FIORITO ,  Andrew WASMUTH

    IPC分类号： C07D471/04 ,  C07D471/14

    摘要： The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibition of phosphodiesterase comprising contacting phosphodiesterase with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. The invention further provides for methods for treatment of neurodegenerative diseases, increasing memory or long term potentiation with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the phosphodiesterase is PDE5.

    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
    4.
    发明申请
    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF 审中-公开
    新型磷酸酯酶抑制剂及其用途

    公开(公告)号：US20160152612A1

    公开(公告)日：2016-06-02

    申请号：US14905246

    申请日：2014-07-17

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Donald W. LANDRY ,  Shixian DENG ,  Ottavio ARANCIO ,  Jole FLORITO ,  Andrew WASMUTH

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibition of phosphodiesterase comprising contacting phosphodiesterase with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. The invention further provides for methods for treatment of neurodegenerative diseases, increasing memory or long term potentiation with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the phosphodiesterase is PDE5.

    摘要翻译： 本发明提供新的苯并萘啶衍生物和包含新的苯并萘啶衍生物的组合物。 在一些实施方案中，化合物是磷酸二酯酶抑制剂。 本发明还提供了抑制磷酸二酯酶的方法，包括使磷酸二酯酶与新的苯并萘啶衍生物或包含新的苯并萘啶衍生物的组合物接触。 本发明进一步提供治疗神经变性疾病的方法，增加记忆力或使用新的苯并萘啶衍生物或包含新的苯并萘啶衍生物的组合物的长期增强作用。 在一些实施方案中，磷酸二酯酶是PDE5。

    MAP KINASE MODULATORS AND USES THEREOF
    5.
    发明申请
    MAP KINASE MODULATORS AND USES THEREOF 有权
    MAP激酶调节剂及其用途

    公开(公告)号：US20160130253A1

    公开(公告)日：2016-05-12

    申请号：US14855035

    申请日：2015-09-15

    申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  Northwestern University

    发明人： Ottavio ARANCIO ,  Daniel Martin WATTERSON ,  Jeffrey Claude PELLETIER ,  Saktimayee Mitra ROY

    IPC分类号： C07D401/14 ,  C07D401/04

    CPC分类号： C07D401/14 ,  C07D401/04

    摘要： The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.

    摘要翻译： 本发明提供了新的MAP激酶抑制剂及其组合物。 在一些实施方案中，MAP激酶抑制剂是p38αMAP激酶抑制剂。 本发明还提供了治疗疾病的方法，包括施用MAP激酶抑制剂或包含MAP激酶抑制剂的组合物。 在一些实施方案中，该疾病是阿尔茨海默病，ALS，亨廷顿病或帕金森病。