公开(公告)号：US20220127232A1

公开(公告)日：2022-04-28

申请号：US17429049

申请日：2020-02-07

申请人： The Trustees of Columbia University in the City of New York ,  APPIA PHARMACEUTICALS LLC

发明人： Ottavio ARANCIO ,  Elisa ZUCCARELLO ,  Elisa CALCAGNO ,  Donald W. LANDRY ,  Shixian DENG ,  Jole FIORITO ,  Luuk Elard DE VRIES ,  Christopher John YARNOLD ,  Richard Scott JONES ,  Julian Hugh ROWLEY

IPC分类号： C07D213/82 ,  C07C235/44 ,  C07D213/75 ,  A61P25/28

摘要： Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

公开(公告)号：US20220125748A1

公开(公告)日：2022-04-28

申请号：US17429048

申请日：2020-02-07

申请人： The Trustees of Columbia University in the City of New York

发明人： Ottavio ARANCIO ,  Donald W. LANDRY ,  Shixian DENG ,  Jennifer Effie AMENGUAL ,  Elisa ZUCCARELLO ,  Jole FIORITO ,  Yuxuan LIU ,  Elisa CALCAGNO ,  Luuk Elard DE VRIES

IPC分类号： A61K31/167 ,  A61K38/15 ,  C07C235/56 ,  A61P25/28

摘要： The invention provides for compounds that are HAT activators or inhibitors. The invention further provides a method for treating neurodegenerative diseases, cancer and other malignant conditions, or to increase memory in a subject not suffering from a neurodegenerative disease by administering HAT activators or inhibitors to a subject in need thereof. The method further comprises co-administration of HD AC inhibitors with HAT activators or HD AC activators with HAT inhibitors.