专利检索 ap:("The Trustees of Columbia University in the City of New York") AND inv:"Yuxuan LIU" 第 1 页

1.

发明申请
HISTONE ACETYLTRANSFERASE (HAT) REGULATORS AND USES THEREOF 有权

公开(公告)号：US20220125748A1

公开(公告)日：2022-04-28

申请号：US17429048

申请日：2020-02-07

申请人： The Trustees of Columbia University in the City of New York

发明人： Ottavio ARANCIO , Donald W. LANDRY , Shixian DENG , Jennifer Effie AMENGUAL , Elisa ZUCCARELLO , Jole FIORITO , Yuxuan LIU , Elisa CALCAGNO , Luuk Elard DE VRIES

IPC分类号： A61K31/167 , A61K38/15 , C07C235/56 , A61P25/28

摘要： The invention provides for compounds that are HAT activators or inhibitors. The invention further provides a method for treating neurodegenerative diseases, cancer and other malignant conditions, or to increase memory in a subject not suffering from a neurodegenerative disease by administering HAT activators or inhibitors to a subject in need thereof. The method further comprises co-administration of HD AC inhibitors with HAT activators or HD AC activators with HAT inhibitors.