公开(公告)号：US20230140435A1

公开(公告)日：2023-05-04

申请号：US17906522

申请日：2021-03-16

申请人： The Trustees of the University of Pennsylvania

发明人： Benjamin L. Prosser ,  Kenneth B. Margulies ,  Alexey Bogush

IPC分类号： C12N15/113 ,  A61K38/53 ,  A61P9/04 ,  A61K45/06 ,  C12N15/86 ,  C12N15/85

摘要： A recombinant viral vector comprising an expression cassette which comprises a coding sequence for an shRNA inhibitor of vasohibin (VASH)-small vasohibin binding protein (SVBP) complex operably linked to regulatory sequences which direct expression thereof is provided. Further provided are compositions containing such viral vectors formulated for delivery to a human patient. Also provided are methods using these vectors and compositions for improving or stabilizing cardiac function.

公开(公告)号：US20230148068A1

公开(公告)日：2023-05-11

申请号：US17982147

申请日：2022-11-07

申请人： Case Western Reserve University ,  The Trustees of the University of Pennsylvania

发明人： Anant Madabhushi ,  Sara Arabyarmohammadi ,  Cai Yuan ,  Eliot G. Peyster ,  Kenneth B. Margulies ,  Michael D. Feldman ,  Priti Lal

IPC分类号： G06T7/00 ,  A61B5/00

CPC分类号： G06T7/0014 ,  A61B5/413 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30048

摘要： The present disclosure in some embodiments relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, including obtaining one or more digitized endomyocardial biopsy (EMB) images from a patient having had a heart transplant; extracting a plurality of histological features from the one or more digitized EMB images; and applying a machine learning predictive model to operate on the plurality of histological features to generate a prediction for the patient. The prediction includes a grade or a clinical trajectory associated with the patient.

公开(公告)号：US20230366891A1

公开(公告)日：2023-11-16

申请号：US18246604

申请日：2021-09-24

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Eliot Peyster ,  Kenneth B. Margulies ,  Michael Feldman

IPC分类号： G01N33/68

CPC分类号： G01N33/6857 ,  G01N2333/7051 ,  G01N2333/70517 ,  G01N2333/7155 ,  G01N2333/70514 ,  G01N2333/70532 ,  G01N2333/70596

摘要： Methods for predicting risk of heart transplant rejection are disclosed.

公开(公告)号：US20180326022A1

公开(公告)日：2018-11-15

申请号：US15959181

申请日：2018-04-21

申请人： The Trustees of the University of Pennsylvania

发明人： Benjamin L. Prosser ,  Kenneth B. Margulies

IPC分类号： A61K38/48 ,  A61P9/04 ,  A61K48/00 ,  A61K31/365

CPC分类号： A61K38/48 ,  A61K31/165 ,  A61K31/365 ,  A61K31/4184 ,  A61K31/475 ,  A61K48/0066 ,  A61K2300/00 ,  A61P9/04 ,  C12Y304/17017 ,  C12Y603/02025

摘要： Described herein is a method for improving or stabilizing cardiac function by inhibiting tubulin carboxypeptidase (TCP). Also described herein is a method for treating heart failure in humans comprising dosing a patient with a therapeutic which interferes with detyrosinated microtubules in cardiomyocytes. Also provided are viral vectors which comprise a nucleic acid encoding a tubulin tyrosine ligase (TTL) gene under the control of regulatory elements direct expression thereof. Compositions are also provided which contain such viral vectors formulated for delivery to a human patient.