公开(公告)号：US20180111981A1

公开(公告)日：2018-04-26

申请号：US15411065

申请日：2017-01-20

申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services

发明人： Zhaochun CHEN ,  Robert H. PURCELL ,  Suzanne U. EMERSON ,  Stephen H. LEPPLA ,  Mahtab MOAYERI

IPC分类号： C07K16/12 ,  G01N33/569 ,  C07K16/40 ,  G01N33/573 ,  A61K51/10 ,  A61K39/00

CPC分类号： C07K16/1278 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56911 ,  G01N33/573 ,  G01N2333/32 ,  G01N2333/954 ,  G01N2469/10

摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

公开(公告)号：US20170114120A9

公开(公告)日：2017-04-27

申请号：US14663168

申请日：2015-03-19

申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services

发明人： Zhaochun CHEN ,  Patricia EARL ,  Bernard MOSS ,  Suzanne U. EMERSON ,  Robert H. PURCELL

IPC分类号： C07K16/08 ,  G01N33/569

CPC分类号： C07K16/081 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2710/24122 ,  G01N33/56983 ,  G01N2333/07

摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

公开(公告)号：US20150252098A1

公开(公告)日：2015-09-10

申请号：US14663168

申请日：2015-03-19

申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services

发明人： Zhaochun CHEN ,  Patricia EARL ,  Bernard MOSS ,  Suzanne U. EMERSON ,  Robert H. PURCELL

IPC分类号： C07K16/08 ,  G01N33/569

CPC分类号： C07K16/081 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2710/24122 ,  G01N33/56983 ,  G01N2333/07

摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.