公开(公告)号：US20190016786A1

公开(公告)日：2019-01-17

申请号：US16044083

申请日：2018-07-24

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv

发明人： Peter D. Kwong ,  Gary J. Nabel ,  Rebecca S. Rudicell ,  John Mascola ,  Mark Connors ,  Ivelin Georgiev ,  Jiang Zhu ,  Young Do Kwon ,  Tongqing Zhou ,  Yongping Yang ,  Baoshan Zhang ,  Gwo-Yu Chuang ,  Xueling Wu ,  Zhi-yong Yang ,  Wei Shi

IPC分类号： C07K16/10 ,  A61K45/06 ,  G01N33/569 ,  A61K39/42 ,  A61K39/00

摘要： Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.

公开(公告)号：US20190070146A1

公开(公告)日：2019-03-07

申请号：US16178277

申请日：2018-11-01

申请人： New York Blood Center, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Serv

发明人： Asim Kumar Debnath ,  Francesca Curreli ,  Peter D. Kwong ,  Young Do Kwon

IPC分类号： A61K31/40 ,  C07C233/01 ,  C07C25/00 ,  C07D207/30 ,  C07D417/14 ,  C07D277/20 ,  C07D403/12 ,  C07D405/14 ,  C07D417/12 ,  C07D207/34 ,  A61P31/18

CPC分类号： A61K31/40 ,  A61P31/18 ,  C07C25/00 ,  C07C233/01 ,  C07D207/30 ,  C07D207/34 ,  C07D277/20 ,  C07D403/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.

公开(公告)号：US20170267748A1

公开(公告)日：2017-09-21

申请号：US15612846

申请日：2017-06-02

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv

发明人： Peter D. Kwong ,  Gary J. Nabel ,  Rebecca S. Rudicell ,  John Mascola ,  Mark Connors ,  Ivelin Georgiev ,  Jiang Zhu ,  Young Do Kwon ,  Tongqing Zhou ,  Yongping Yang ,  Baoshan Zhang ,  Gwo-Yu Chuang ,  Xueling Wu ,  Zhi-yong Yang ,  Wei Shi

IPC分类号： C07K16/10 ,  A61K45/06 ,  A61K39/42 ,  G01N33/569

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/56988

摘要： Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.

公开(公告)号：US20140377219A1

公开(公告)日：2014-12-25

申请号：US14241329

申请日：2012-09-06

申请人： New york Blood Center, Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Serv

发明人： Asim Kumar Debnath ,  Francesca Curreli ,  Peter D. Kwong ,  Young Do Kwon

IPC分类号： C07D417/14 ,  A61K31/538 ,  C07D417/06 ,  A61K31/427 ,  C07D223/04 ,  A61K45/06 ,  C07D211/14 ,  A61K31/445 ,  A61K31/495 ,  C07D307/54 ,  A61K31/341 ,  A61K31/454 ,  A61K31/55

CPC分类号： C07D417/14 ,  A61K31/167 ,  A61K31/341 ,  A61K31/40 ,  A61K31/427 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/538 ,  A61K31/55 ,  A61K45/06 ,  C07D207/16 ,  C07D211/14 ,  C07D211/42 ,  C07D211/46 ,  C07D211/58 ,  C07D213/81 ,  C07D215/12 ,  C07D223/04 ,  C07D231/40 ,  C07D233/58 ,  C07D295/192 ,  C07D295/26 ,  C07D307/52 ,  C07D307/54 ,  C07D401/06 ,  C07D417/06 ,  C07D487/04 ,  A61K2300/00

摘要： Chemical compounds that inhibit retroviruses are presented herein. More particularly, this disclosure provides small molecule compounds that inhibit infection with, or treat infection caused by, human immunodeficiency viruses.

摘要翻译： 本文给出抑制逆转录病毒的化合物。 更具体地，本公开提供抑制人免疫缺陷病毒感染或治疗由人免疫缺陷病毒引起的感染的小分子化合物。

公开(公告)号：US20170273943A1

公开(公告)日：2017-09-28

申请号：US15512493

申请日：2015-09-18

申请人： New York Blood Center, Inc. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Serv

发明人： Asim Kumar Debnath ,  Francesca Curreli ,  Peter D. Kwong ,  Young Do Kwon

IPC分类号： A61K31/40 ,  C07C25/00 ,  C07D277/20 ,  C07D207/30 ,  C07C233/01

CPC分类号： A61K31/40 ,  A61P31/18 ,  C07C25/00 ,  C07C233/01 ,  C07D207/30 ,  C07D207/34 ,  C07D277/20 ,  C07D403/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

摘要： Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.