专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Services") AND inv:"Lydie Cassard" 第 1 页

1.

发明授权
GP100-specific T cell receptors and related materials and methods of use 有权

公开(公告)号：US09522948B2

公开(公告)日：2016-12-20

申请号：US14106031

申请日：2013-12-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg

IPC分类号： C07H21/02 , C12N15/00 , C07K14/705 , C07K14/725 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/574 , A61K38/00

CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492

摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.