专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Services") AND inv:"Nicholas P. Restifo" 第 1 页

1.

发明授权
Intracellular genomic transplant and methods of therapy 有权

公开(公告)号：US11642374B2

公开(公告)日：2023-05-09

申请号：US16182146

申请日：2018-11-06

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo

IPC分类号： A61P35/00 , A61K35/17 , A61K48/00 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87

CPC分类号： A61K35/17 , C07K14/4718 , C07K14/7051 , C07K14/70503 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00

摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

2.

发明授权
Methods of producing T memory stem cell populations 有权

公开(公告)号：US11111478B2

公开(公告)日：2021-09-07

申请号：US16410327

申请日：2019-05-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Luca Gattinoni , Enrico Lugli , Mario Roederer , Nicholas P. Restifo

IPC分类号： C12N15/85 , C12N5/0783 , A61K35/17 , A61K39/00

摘要： Provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating naïve T cells from a mammal, wherein the mammal is not a mouse; b) activating the naïve T cells and expanding the numbers of naïve T cells in the presence of one or more non-specific T cell stimuli, one or more cytokines, and a GSK-3beta inhibitor. Also provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating lymphocytes from a mammal; b) sorting the lymphocytes using flow cytometry into a population comprising a phenotype comprising i) CD95+, CD45RO−, and CCR7+; and ii) CD62L+ or one or more of CD27+, CD28+, CD45RA+, and CD127+ to produce an isolated T memory stem cell population. Further embodiments of the invention provide related cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.

3.

发明申请
METHODS OF PREPARING HEMATOPOIETIC PROGENITOR CELLS IN VITRO 审中-公开

公开(公告)号：US20200263136A1

公开(公告)日：2020-08-20

申请号：US16762447

申请日：2018-11-08

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Raul E. Vizcardo , Naritaka Tamaoki , Meghan L. Good , Nicholas P. Restifo

IPC分类号： C12N5/0789 , A61K35/28

摘要： Disclosed are methods of preparing CD34+CD43+ hematopoietic progenitor cells (HPC) in vitro according to embodiments of the invention. Also disclosed are methods of differentiating CD34+CD43+ hematopoietic progenitor cells to hematopoietic lineage cells according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e.g., cancer, according to embodiments of the invention.

4.

发明授权
In vitro generation of thymic organoid from human pluripotent stem cells 有权

公开(公告)号：US11898166B2

公开(公告)日：2024-02-13

申请号：US16648008

申请日：2018-09-19

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Raul E. Vizcardo , Nicholas P. Restifo

IPC分类号： C12N5/078 , A61K35/26

CPC分类号： C12N5/065 , A61K35/26 , C12N2500/98 , C12N2501/105 , C12N2501/117 , C12N2501/15 , C12N2501/41 , C12N2501/415 , C12N2506/45 , C12N2513/00

摘要： Disclosed are methods of preparing thymic organoids according to embodiments of the invention. Also disclosed are methods of preparing thymic emigrant cells in vitro, according to embodiments of the invention. Also disclosed are methods of treating or preventing a condition in a mammal, e g., cancer.

5.

发明申请
METHODS OF PRODUCING T MEMORY STEM CELL POPULATIONS 有权

公开(公告)号：US20210395683A1

公开(公告)日：2021-12-23

申请号：US17465577

申请日：2021-09-02

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Luca Gattinoni , Enrico Lugli , Mario Roederer , Nicholas P. Restifo

IPC分类号： C12N5/0783 , A61K35/17

摘要： Provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating naïve T cells from a mammal, wherein the mammal is not a mouse; b) activating the naïve T cells and expanding the numbers of naïve T cells in the presence of one or more non-specific T cell stimuli, one or more cytokines, and a GSK-3beta inhibitor. Also provided are methods of producing an isolated T memory stem cell population, the method comprising a) isolating lymphocytes from a mammal; b) sorting the lymphocytes using flow cytometry into a population comprising a phenotype comprising i) CD95+, CD45RO−, and CCR7+; and ii) CD62L+ or one or more of CD27+, CD28+, CD45RA+, and CD127+ to produce an isolated T memory stem cell population. Further embodiments of the invention provide related cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.

6.

发明授权
Modified cells and methods of therapy 有权

公开(公告)号：US11147837B2

公开(公告)日：2021-10-19

申请号：US15256086

申请日：2016-09-02

申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity , Beau Webber , Modassir Choudhry , R. Scott McIvor , David Largaespada , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo

IPC分类号： A61K35/17 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87

摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

7.

发明申请
METHODS OF PRODUCING T CELL POPULATIONS USING P38 MAPK INHIBITORS 审中-公开

公开(公告)号：US20200316122A1

公开(公告)日：2020-10-08

申请号：US16754926

申请日：2018-10-10

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Shashankkumar J. Patel , Nicholas P. Restifo

IPC分类号： A61K35/17 , C12N5/0783 , A61P35/00

摘要： Provided are methods of producing an isolated population of T cells for adoptive cell therapy, the method comprising culturing isolated T cells in vitro in the presence of a p38 mitogen activated protein kinase (p38 MAPK) inhibitor, wherein the T cells have antigenic specificity for a cancer antigen. Also provided are related isolated populations of T cells, pharmaceutical compositions, and methods of treating or preventing cancer in a mammal.

8.

发明申请
METHODS OF PREPARING AN ISOLATED OR PURIFIED POPULATION OF THYMIC EMIGRANT CELLS AND METHODS OF TREATMENT USING SAME 审中-公开

公开(公告)号：US20200080057A1

公开(公告)日：2020-03-12

申请号：US16468890

申请日：2017-12-13

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Raul E. Vizcardo , Nicholas D. Klemen , Nicholas P. Restifo

IPC分类号： C12N5/0783 , A61K35/17 , A61P35/00

摘要： Disclosed are methods of preparing thymic emigrant cells in vitro, isolated or purified thymic emigrant cells prepared by the methods, and pharmaceutical compositions comprising the same. Further disclosed are methods of treating or preventing a condition in a mammal comprising administering the thymic emigrant cells or pharmaceutical compositions comprising the same to the mammal.