专利检索 ap:("The United States of America, as represented by the Secretary, Dept. of Health AND Human Services") AND inv:"Patricia Earl" 第 1 页

1.

发明授权
Monoclonal antibodies against orthopoxviruses 有权

公开(公告)号：US09708392B2

公开(公告)日：2017-07-18

申请号：US14663168

申请日：2015-03-19

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Zhaochun Chen , Patricia Earl , Bernard Moss , Suzanne U. Emerson , Robert H. Purcell

IPC分类号： C07K14/005 , C07K16/08 , G01N33/569 , A61K39/00

CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07

摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.