公开(公告)号：US09580492B2

公开(公告)日：2017-02-28

申请号：US14595475

申请日：2015-01-13

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Zhaochun Chen ,  Robert H. Purcell ,  Suzanne U. Emerson ,  Stephen H. Leppla ,  Mahtab Moayeri

IPC分类号： G01N33/573 ,  C07K16/12 ,  C07K16/40 ,  A61K51/10 ,  G01N33/569 ,  A61K39/00

CPC分类号： C07K16/1278 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56911 ,  G01N33/573 ,  G01N2333/32 ,  G01N2333/954 ,  G01N2469/10

摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

摘要翻译： 本发明涉及结合或中和炭疽致死因子（LF），水肿因子（EF）和/或保护性抗原（PA）的单克隆抗体。 本发明提供了这样的抗体，这种抗体的保留了炭疽毒素结合能力的片段，完全人或人源化抗体，保留了炭疽毒素结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。

公开(公告)号：US10053503B2

公开(公告)日：2018-08-21

申请号：US15411065

申请日：2017-01-20

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Zhaochun Chen ,  Robert H. Purcell ,  Suzanne U. Emerson ,  Stephen H. Leppla ,  Mahtab Moayeri

IPC分类号： C07K16/40 ,  C12Q1/68 ,  C07K16/12 ,  G01N33/573 ,  A61K51/10 ,  G01N33/569 ,  A61K39/00

CPC分类号： C07K16/1278 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56911 ,  G01N33/573 ,  G01N2333/32 ,  G01N2333/954 ,  G01N2469/10

摘要： The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

公开(公告)号：US09708392B2

公开(公告)日：2017-07-18

申请号：US14663168

申请日：2015-03-19

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Zhaochun Chen ,  Patricia Earl ,  Bernard Moss ,  Suzanne U. Emerson ,  Robert H. Purcell

IPC分类号： C07K14/005 ,  C07K16/08 ,  G01N33/569 ,  A61K39/00

CPC分类号： C07K16/081 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2710/24122 ,  G01N33/56983 ,  G01N2333/07

摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.