公开(公告)号：US10925874B2

公开(公告)日：2021-02-23

申请号：US15983844

申请日：2018-05-18

申请人： The United States of America, as Represented by the Secretary, Department of Health and Human Service

发明人： Juan Jose Marugan ,  Noel Southall ,  Ehud Goldin ,  Wei Zheng ,  Samarjit Patnaik ,  Ellen Sidransky ,  Omid Motabar ,  Wendy Westbroek

IPC分类号： C07D487/02 ,  A61K31/519 ,  A61P43/00 ,  C07D487/04 ,  A61K31/5377

摘要： Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.

公开(公告)号：US20140323438A1

公开(公告)日：2014-10-30

申请号：US14364759

申请日：2012-12-17

申请人： The United States of America,as represented by the Secretary, Department of Health and Human Service

发明人： Kevin Frankowski ,  Samarjit Patnaik ,  Sui Huang ,  Juan Jose Marugan ,  John Norton ,  Frank J. Schoenen ,  Noel Terrence Southall ,  Steven Titus ,  Wei Zheng

IPC分类号： C07D487/04 ,  C07F7/18 ,  A61K45/06 ,  A61K31/695 ,  A61K31/519

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/695 ,  A61K45/06 ,  C07F7/1804

摘要： The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.

摘要翻译： 本公开内容提供了用于降低细胞中例如式（I）的细胞周围隔室的化合物，其中R 1，R 2，R 3和R 4如本文所定义，其可用于治疗与增加的疾病或病症相关的疾病或病症 周围隔室的流行，如癌症。 还公开了含有药学上可接受的载体和至少一种体现本发明原理的化合物以及治疗或预防哺乳动物癌症的方法的组合物。