公开(公告)号：US20230218519A1

公开(公告)日：2023-07-13

申请号：US18009144

申请日：2021-06-11

申请人： The University of Birmingham

发明人： Anthony METCALFE ,  Richard Williams ,  Richard Moakes ,  Liam Grover

IPC分类号： A61K9/06 ,  A61K47/10 ,  A61K47/42 ,  A61K47/02 ,  A61K47/36 ,  A61K47/08 ,  A61K38/17 ,  A61K31/573 ,  A61K31/7036 ,  A61K9/00 ,  A61K38/48

CPC分类号： A61K9/06 ,  A61K47/10 ,  A61K47/42 ,  A61K47/02 ,  A61K47/36 ,  A61K47/08 ,  A61K38/1709 ,  A61K31/573 ,  A61K31/7036 ,  A61K9/0048 ,  A61K38/482

摘要： Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

公开(公告)号：US20230240988A1

公开(公告)日：2023-08-03

申请号：US18009485

申请日：2021-06-11

申请人： The University of Birmingham

发明人： Anthony Metcalfe ,  Richard Williams ,  Richard Moakes ,  Liam Grover

IPC分类号： A61K9/06 ,  A61K31/7008 ,  A61K31/573 ,  A61K38/48 ,  A61K31/192 ,  A61K31/721 ,  A61K9/00

CPC分类号： A61K9/06 ,  A61K31/7008 ,  A61K31/573 ,  A61K38/482 ,  A61K31/192 ,  A61K31/721 ,  A61K9/0014 ,  A61K9/0048 ,  C12Y304/21064

摘要： Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

公开(公告)号：US20230210891A1

公开(公告)日：2023-07-06

申请号：US18009566

申请日：2021-06-11

申请人： The University of Birmingham

发明人： Hannah Botfield ,  Lisa Hill ,  Richard Moakes ,  Liam Grover

IPC分类号： A61K31/737 ,  A61K31/727 ,  A61K9/00 ,  A61P27/06 ,  A61K47/36

CPC分类号： A61K31/737 ,  A61K9/0048 ,  A61K31/727 ,  A61K47/36 ,  A61P27/06

摘要： Provided are pharmaceutical compositions comprising a sulphated polysaccharide and a shear-thinning fluid gel. The sulphated polysaccharide may, by way of example, be selected from the group consisting of: a dextran sulphate having an average molecular weight of 10,000 Da or less; heparan sulphate; fucoidan; poligeenan; furcellaran; and a carrageenan. The shear-thinning fluid gel may comprise a microgel particle forming polymer, suitably selected from one or more of the following groups: gellans; alginates; carrageenans; agarose; chitosan; pectin; agarose; agar or gelatin. The compositions disclosed may be used for the prevention and/or treatment of glaucoma. These compositions may be used for the inhibition or reduction of fibrosis. The invention also relates to the medical uses of sulphated polysaccharides, and the medical uses of shear-thinning fluid gels.