公开(公告)号：US20230240988A1

公开(公告)日：2023-08-03

申请号：US18009485

申请日：2021-06-11

Applicant: The University of Birmingham

Inventor： Anthony Metcalfe ,  Richard Williams ,  Richard Moakes ,  Liam Grover

IPC: A61K9/06 ,  A61K31/7008 ,  A61K31/573 ,  A61K38/48 ,  A61K31/192 ,  A61K31/721 ,  A61K9/00

CPC classification number: A61K9/06 ,  A61K31/7008 ,  A61K31/573 ,  A61K38/482 ,  A61K31/192 ,  A61K31/721 ,  A61K9/0014 ,  A61K9/0048 ,  C12Y304/21064

Abstract: Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

公开(公告)号：US20230218519A1

公开(公告)日：2023-07-13

申请号：US18009144

申请日：2021-06-11

Applicant: The University of Birmingham

Inventor： Anthony METCALFE ,  Richard Williams ,  Richard Moakes ,  Liam Grover

IPC: A61K9/06 ,  A61K47/10 ,  A61K47/42 ,  A61K47/02 ,  A61K47/36 ,  A61K47/08 ,  A61K38/17 ,  A61K31/573 ,  A61K31/7036 ,  A61K9/00 ,  A61K38/48

CPC classification number: A61K9/06 ,  A61K47/10 ,  A61K47/42 ,  A61K47/02 ,  A61K47/36 ,  A61K47/08 ,  A61K38/1709 ,  A61K31/573 ,  A61K31/7036 ,  A61K9/0048 ,  A61K38/482

Abstract: Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

公开(公告)号：US11213607B2

公开(公告)日：2022-01-04

申请号：US16060877

申请日：2016-12-09

Applicant: The University of Birmingham

Inventor： Liam Grover ,  Paula Mendes ,  Richard Williams

IPC: A61L27/20 ,  A61L27/38 ,  H01J49/00 ,  A61L27/22 ,  A61L27/24 ,  A61L27/54 ,  C07K1/22 ,  C07K16/28 ,  A61L27/46 ,  H01J49/06 ,  A61K47/36 ,  A61K47/42 ,  A61K47/02

Abstract: The invention provides a cell binding composition comprising a shear thinning gel wherein the shear thinning gel having attached to it one or more cell selective binding agents, or the shear thinning gel having dispersed therein a plurality of gel beads, the gel beads having attached to them one or more cell selective binding agents.
Methods of enriching cells using the compositions and using the cells to treat injury or disease are also provided.