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    Methods and systems for closed-loop control of drug administration
    3.
    发明申请
    Methods and systems for closed-loop control of drug administration 审中-公开

    公开(公告)号：US20180296759A1

    公开(公告)日：2018-10-18

    申请号：US15979661

    申请日：2016-11-23

    申请人： The University of British Columbia

    发明人： Guy Dumont ,  Mark Ansermino ,  Sara Khosravi ,  Nicholas West

    IPC分类号： A61M5/172 ,  G16H20/13

    摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

    Methods and systems for closed-loop control of drug administration
    4.
    发明申请
    Methods and systems for closed-loop control of drug administration 有权

    公开(公告)号：US20220211943A1

    公开(公告)日：2022-07-07

    申请号：US17590017

    申请日：2022-02-01

    申请人： The University of British Columbia

    发明人： Guy Dumont ,  Mark Ansermino ,  Sara Khosravi ,  Nicholas West

    IPC分类号： A61M5/172 ,  A61B5/00 ,  A61B5/369 ,  G16H20/13

    摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

    Methods and systems for closed-loop control of drug administration
    5.
    发明授权
    Methods and systems for closed-loop control of drug administration 有权

    公开(公告)号：US11266780B2

    公开(公告)日：2022-03-08

    申请号：US15979661

    申请日：2016-11-23

    申请人： The University of British Columbia

    发明人： Guy Dumont ,  Mark Ansermino ,  Sara Khosravi ,  Nicholas West

    IPC分类号： A61M5/172 ,  A61B5/00 ,  A61B5/369 ,  G16H20/13 ,  A61M5/14 ,  A61M5/142

    摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.