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公开(公告)号：US11116897B2
公开(公告)日：2021-09-14
申请号：US16149575
申请日：2017-04-12
发明人： Guy Dumont , Klaske Van Heusden , Mark Ansermino
摘要： The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further relates to such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.
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公开(公告)号：US20220211943A1
公开(公告)日：2022-07-07
申请号：US17590017
申请日：2022-02-01
发明人： Guy Dumont , Mark Ansermino , Sara Khosravi , Nicholas West
摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
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公开(公告)号：US11266780B2
公开(公告)日：2022-03-08
申请号：US15979661
申请日：2016-11-23
发明人： Guy Dumont , Mark Ansermino , Sara Khosravi , Nicholas West
摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
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公开(公告)号：US11883631B2
公开(公告)日：2024-01-30
申请号：US17590017
申请日：2022-02-01
发明人： Guy Dumont , Mark Ansermino , Sara Khosravi , Nicholas West
CPC分类号： A61M5/1723 , A61B5/00 , A61B5/369 , A61B5/4821 , A61B5/4839 , A61B5/725 , A61M5/172 , G16H20/13 , A61M5/14 , A61M2005/14296 , A61M2202/048 , A61M2205/3303 , A61M2205/50 , A61M2230/06 , A61M2230/10 , A61M2230/30 , A61M2230/42 , A61M2230/43
摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
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公开(公告)号：US20190143036A1
公开(公告)日：2019-05-16
申请号：US16149575
申请日：2017-04-12
发明人： Guy Dumont , Klaske Van Heusden , Mark Ansermino
摘要： The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further relates to such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.
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公开(公告)号：US20240216610A1
公开(公告)日：2024-07-04
申请号：US18541187
申请日：2023-12-15
发明人： Guy Dumont , Mark Ansermino , Sara Khosravi , Nicholas West
CPC分类号： A61M5/1723 , A61B5/00 , A61B5/369 , A61B5/4821 , A61B5/4839 , A61B5/725 , A61M5/172 , G16H20/13 , A61M5/14 , A61M2005/14296 , A61M2202/048 , A61M2205/3303 , A61M2205/50 , A61M2230/06 , A61M2230/10 , A61M2230/30 , A61M2230/42 , A61M2230/43
摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
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公开(公告)号：US20220031945A1
公开(公告)日：2022-02-03
申请号：US17398370
申请日：2021-08-10
发明人： Guy Dumont , Klaske Van Heusden , Mark Ansermino
摘要： The invention relates to administration of clinical anesthesia. Particular embodiments provide systems and methods for controlled delivery of a combination of an analgesic agent and a hypnotic agent. More specifically, the invention relates to closed-loop control systems/methods for automatically controlling the administration of a combination of a hypnotic agent and an analgesic agent in a clinical anesthesia setting which incorporate feedback based on one or more indirect measures/indicia of analgesia. The invention further relates to such control systems/methods that account for limitations of such indirect measures/indicia of analgesia.
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公开(公告)号：US20180296759A1
公开(公告)日：2018-10-18
申请号：US15979661
申请日：2016-11-23
发明人： Guy Dumont , Mark Ansermino , Sara Khosravi , Nicholas West
摘要： A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.
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