公开(公告)号：US20240092867A1

公开(公告)日：2024-03-21

申请号：US18352101

申请日：2023-07-13

申请人： The University of Chicago ,  Imperial College Innovations Limited

发明人： Jeffrey A. HUBBELL ,  Anna M. RANDI ,  Jun ISHIHARA ,  Ako ISHIHARA ,  Priscilla BRIQUEZ ,  Richard STARKE

IPC分类号： C07K14/78 ,  A61K9/00 ,  A61K9/70 ,  A61K38/00 ,  A61K38/18 ,  A61K38/39 ,  A61K47/64 ,  A61K47/69 ,  A61L27/22 ,  A61P17/02 ,  C07K14/475 ,  C07K14/705 ,  C07K14/81 ,  C07K16/18

CPC分类号： C07K14/78 ,  A61K9/0024 ,  A61K9/7007 ,  A61K38/00 ,  A61K38/18 ,  A61K38/39 ,  A61K47/6435 ,  A61K47/6903 ,  A61L27/22 ,  A61P17/02 ,  C07K14/475 ,  C07K14/70546 ,  C07K14/8121 ,  C07K16/18 ,  A61L2300/412 ,  C07K2317/55 ,  C07K2319/70

摘要： The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.

公开(公告)号：US20240044896A1

公开(公告)日：2024-02-08

申请号：US18266381

申请日：2021-12-09

申请人： The University of Chicago

发明人： Melody SWARTZ ,  Priscilla BRIQUEZ ,  Jeffrey HUBBELL

IPC分类号： G01N33/569 ,  C07K14/165

CPC分类号： G01N33/56983 ,  C07K14/165 ,  G01N2333/165 ,  G01N2333/575 ,  G01N2469/20 ,  G01N2800/32

摘要： Aspects of the disclosure are directed to methods, systems, and compositions for detecting antibodies capable of binding to angiotensin II. Certain aspects comprise detection of antibodies capable of binding to angiotensin II in a sample from a subject, where the subject has or has had a coronavirus infection, such as a SARS-CoV-2 infection. Also disclosed are vaccine compositions comprising a portion of SARS-CoV-2 Spike protein, where such compositions do not induce generation of angiotensin II-binding antibodies.

公开(公告)号：US20210040179A1

公开(公告)日：2021-02-11

申请号：US15733085

申请日：2018-11-13

申请人： The University of Chicago ,  Imperial Innovations

发明人： Jeffrey A. HUBBELL ,  Anna M. RANDI ,  Jun ISHIHARA ,  Ako ISHIHARA ,  Priscilla BRIQUEZ ,  Richard STARKE

IPC分类号： C07K14/78 ,  C07K16/18 ,  A61P17/02 ,  A61L27/22 ,  A61K38/00

摘要： The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.