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14 条记录 (耗时 0.054 秒)

    Methods of diagnosing tissue fibrosis
    8.
    发明申请
    Methods of diagnosing tissue fibrosis 有权
    诊断组织纤维化的方法

    公开(公告)号：US20050186561A1

    公开(公告)日：2005-08-25

    申请号：US10971195

    申请日：2004-10-22

    申请人： Esther Oh ,  Catherine Smith

    发明人： Esther Oh ,  Catherine Smith

    IPC分类号： A61B20060101 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/567 ,  G01N33/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/52

    摘要： The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual; and diagnosing the presence or severity of tissue fibrosis in the individual based on the presence or level of α2-MG, HA and TIMP-1.

    摘要翻译： 本发明提供一种通过检测来自个体的样品中的α2-巨球蛋白（α2-MG）来诊断个体中组织纤维化的存在或严重性的方法; 检测来自个体的样品中的透明质酸（HA）; 检测来自个体的样品中金属蛋白酶-1（TIMP-1）的组织抑制剂; 并基于α2-MG，HA和TIMP-1的存在或水平诊断个体中组织纤维化的存在或严重程度。

    Methods of amination
    10.
    发明申请
    Methods of amination 失效
    胺化方法

    公开(公告)号：US20070179315A1

    公开(公告)日：2007-08-02

    申请号：US10593212

    申请日：2005-03-18

    申请人： Andrew Holmes ,  Catherine Smith ,  Melanie Tsang ,  Theresa Early ,  Richard Shute

    发明人： Andrew Holmes ,  Catherine Smith ,  Melanie Tsang ,  Theresa Early ,  Richard Shute

    IPC分类号： C07C209/00

    CPC分类号： C07C227/08 ,  C07C209/10 ,  C07C213/02 ,  C07D207/325 ,  C07D207/327 ,  C07C211/55 ,  C07C217/92 ,  C07C229/60

    摘要： A method of synthesizing a compound of formula I: comprising the step of reacting a moiety of formula II: with a moiety of formula III: in compressed carbon dioxide in the presence of a transition metal catalyst and a base, wherein L is a labile leaving group; RN1 is optionally substituted C5-20 aryl; RN2 is selected from optionally substituted C5-20aryl, optionally substituted C3-20 heterocyclyl, optionally substituted C3-7 alkyl, and optionally substituted sulfonyl; RN3 is selected from H and optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl; or RN2 and RN3 together with the nitrogen atom to which they are attached form optionally substituted nitrogen-containing C3-20 heterocylyl or C5-20 heteroaryl; and R1 R2 and R3 are independently selected from optionally substituted C1-7 alkyl, C5-20 aryl, C3-20 heterocyclyl, hydroxy, halo, amino and C1-7 alkoxy, or two of R1, R2 and R3, together with the silicon atom to which they are attached, may form a silicon containing C5-7 heterocyclyl group.

    摘要翻译： 合成式I化合物的方法：包括使式II部分与式III部分反应的步骤：在过渡金属催化剂和碱的存在下，在压缩二氧化碳中，其中L是不稳定的离去 组; R 01是任选取代的C 5-20芳基; R N2选自任选取代的C 5-20芳基，任选取代的C 3-20杂环基，任选取代的C 3-8芳基， 7烷基和任选取代的磺酰基; R N 3选自H和任选取代的C 1-7 - 烷基，C 3-20 - 杂环基和C 5-20杂环基， / SUB>芳基; 或R N2和R N3与它们所连接的氮原子一起形成任选取代的含氮C 3-20异氰酸酯或C 5-20杂芳基; R 1和R 3独立地选自任选取代的C 1-7烷基，C 1 -C 6烷基， 羟基，卤素，氨基和C 1-7 - 烷氧基，或者R 1，R 2，R 2， 1，R 2和R 3与它们所连接的硅原子一起可以形成含有C 5-7的硅， / SO 2杂环基。