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公开(公告)号：US08440443B1
公开(公告)日：2013-05-14
申请号：US11749550
申请日：2007-05-16
申请人： Thierry O. Fischmann , Hung V. Le , Vincent S. Madison , Anthony F. Mannarino , Todd W. Mayhood , Paul Reichert , Catherine Smith , Tin-Yau Chan
发明人： Thierry O. Fischmann , Hung V. Le , Vincent S. Madison , Anthony F. Mannarino , Todd W. Mayhood , Paul Reichert , Catherine Smith , Tin-Yau Chan
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00 , C07K2319/40
摘要： The present invention provides, inter alia, crystals of the MEK1 polypeptide which are particularly useful for structure based drug design as well as methods of use thereof.
摘要翻译： 本发明特别提供了特别可用于基于结构的药物设计的MEK1多肽的晶体及其使用方法。
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公开(公告)号：US08088611B2
公开(公告)日：2012-01-03
申请号：US12784760
申请日：2010-05-21
申请人： Andrew J. Prongay , Thierry O. Fischmann , Chandra C. Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
发明人： Andrew J. Prongay , Thierry O. Fischmann , Chandra C. Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
摘要翻译： 本发明部分地提供AKT3多肽及其与编码多肽的核酸的使用方法。 例如，本文提供了用于筛选AKT3抑制剂的方法。
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3.发明授权Polynucleotides encoding polypeptide fragments of protein kinase B gamma (AKT3) 失效编码蛋白激酶Bγ（AKT3）多肽片段的多核苷酸公开(公告)号：US07776589B1
公开(公告)日：2010-08-17
申请号：US11847801
申请日：2007-08-30
申请人： Andrew J. Prongay , Thierry O. Fischmann , Chandra Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
发明人： Andrew J. Prongay , Thierry O. Fischmann , Chandra Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
摘要翻译： 本发明部分地提供AKT3多肽及其与编码多肽的核酸的使用方法。 例如，本文提供了用于筛选AKT3抑制剂的方法。
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公开(公告)号：US20100267053A1
公开(公告)日：2010-10-21
申请号：US12784760
申请日：2010-05-21
申请人： ANDREW J. PRONGAY , Thierry O. Fischmann , Chandra Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
发明人： ANDREW J. PRONGAY , Thierry O. Fischmann , Chandra Kumar , Vincent S. Madison , Joseph E. Myers , Paul Reichert , Rosalinda Syto , William T. Windsor , Li Xiao , Todd W. Mayhood
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
摘要翻译： 本发明部分地提供AKT3多肽及其与编码多肽的核酸的使用方法。 例如，本文提供了用于筛选AKT3抑制剂的方法。
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公开(公告)号：US07888474B2
公开(公告)日：2011-02-15
申请号：US12723184
申请日：2010-03-12
申请人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号： C07K14/00
CPC分类号： C07K14/82 , C07K2299/00
摘要： The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译： 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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公开(公告)号：US07705127B1
公开(公告)日：2010-04-27
申请号：US12249314
申请日：2008-10-10
申请人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号： C07K14/00
CPC分类号： C07K14/82 , C07K2299/00
摘要： The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译： 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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7.发明授权Crystalline form of the catalytic domain of Aurora 2 kinase and methods of use thereof 失效Aurora 2激酶催化结构域的结晶形式及其使用方法公开(公告)号：US07422885B1
公开(公告)日：2008-09-09
申请号：US10943438
申请日：2004-09-17
申请人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
发明人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
CPC分类号： C12N9/12
摘要： The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
摘要翻译： 本发明公开了编码活性人Aurora 2激酶催化结构域的核酸。 本发明还公开了生长包含活性人Aurora 2激酶催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人Aurora 2激酶的催化结构域的结晶形式。 此外，本发明公开了在结构辅助药物设计中使用人Aurora 2激酶的X射线衍射晶体的方法来鉴定可调节人Aurora 2激酶的酶活性的化合物。
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8.发明申请CRYSTALLINE FORM OF THE CATALYTIC DOMAIN OF AURORA 2 KINASE AND METHODS OF USE THEREOF 有权AURORA 2激酶的催化域的结晶形式及其使用方法公开(公告)号：US20090081706A1
公开(公告)日：2009-03-26
申请号：US12184770
申请日：2008-08-01
申请人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
发明人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
CPC分类号： C12N9/12
摘要： The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
摘要翻译： 本发明公开了编码活性人Aurora 2激酶催化结构域的核酸。 本发明还公开了生长包含活性人Aurora 2激酶催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人Aurora 2激酶的催化结构域的结晶形式。 此外，本发明公开了在结构辅助药物设计中使用人Aurora 2激酶的X射线衍射晶体的方法来鉴定可调节人Aurora 2激酶的酶活性的化合物。
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9.发明授权公开(公告)号：US07824491B2
公开(公告)日：2010-11-02
申请号：US12184770
申请日：2008-08-01
申请人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
发明人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
CPC分类号： C12N9/12
摘要： The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
摘要翻译： 本发明公开了编码活性人Aurora 2激酶催化结构域的核酸。 本发明还公开了生长包含活性人Aurora 2激酶催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人Aurora 2激酶的催化结构域的结晶形式。 此外，本发明公开了在结构辅助药物设计中使用人Aurora 2激酶的X射线衍射晶体的方法来鉴定可调节人Aurora 2激酶的酶活性的化合物。
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10.发明授权Crystalline form of an n231 mutant catalytic domain of ADAM33 and methods of use thereof 失效ADAM33的n231突变体催化结构域的结晶形式及其使用方法公开(公告)号：US07285408B2
公开(公告)日：2007-10-23
申请号：US10741208
申请日：2003-12-19
申请人： Peter Orth , Paul Reichert , Vincent S. Madison , Wenyan Wang , Jun Zou
发明人： Peter Orth , Paul Reichert , Vincent S. Madison , Wenyan Wang , Jun Zou
CPC分类号： C12N9/6489 , A61K38/00 , C07K2299/00 , Y02A90/26
摘要： The present invention discloses purified polypeptides that comprise an active human ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human ADAM33 catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human ADAM33. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human ADAM33 in structure based drug design to identify compounds that can modulate the enzymatic activity of human ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the human ADAMS33 catalytic domain.
摘要翻译： 本发明公开了包含活性人ADAM33催化结构域的纯化多肽。 此外，本发明公开了编码本发明多肽的核酸。 本发明还公开了生长包含活性人ADAM33催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人ADAM33的催化结构域的结晶形式。 此外，本发明公开了在基于结构的药物设计中使用人ADAM33的X射线衍射晶体的方法来鉴定可以调节人ADAM33的酶活性的化合物。 本发明还公开了通过施用治疗量的人ADAMS33催化结构域来治疗呼吸系统疾病的方法。
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