公开(公告)号：US20140248416A1

公开(公告)日：2014-09-04

申请号：US14353045

申请日：2011-10-28

申请人： Thomas Anthony ,  Yaacov Almog ,  Omar Gila

发明人： Thomas Anthony ,  Yaacov Almog ,  Omar Gila

IPC分类号： A61K9/48

CPC分类号： A61K9/4833 ,  A61J3/078 ,  A61K9/0056 ,  A61K9/7007 ,  B05C9/12 ,  B05C11/025 ,  B05D1/02 ,  B05D1/06 ,  B05D2202/00 ,  B05D2203/30 ,  B05D2401/32 ,  B41J2/3855

摘要： An apparatus for producing a controlled dosage of bioactive agent is disclosed. The apparatus includes: a print device to eject a drop of a mixture onto an ingestible substrate, wherein the drop of mixture includes a bioactive agent within an ingestible carrier fluid and is between 50 ng and 1000 ng in size; a charge generating device adjacent to the print device to generate charge on the bioactive agent to draw the bioactive agent to the ingestible substrate; a cold fluid removal device adjacent to the charge generating device to remove a portion of the ingestible carrier fluid from the bioactive agent; an application device adjacent to the cold fluid removal device to apply an ingestible layer on top of the ingestible substrate encapsulating the bioactive agent or to fold the ingestible substrate on top of the bioactive agent encapsulating the bioactive agent; and a transfer device adjacent to the print device, the charge generating is device, the cold fluid removal device, and the application device to move the ingestible substrate from one device to the next.

摘要翻译： 公开了一种用于生产受控剂量的生物活性剂的设备。 该装置包括：打印装置，用于将一滴混合物喷射到可摄取的基质上，其中所述混合物液滴在可摄取载体流体中包含生物活性剂，其尺寸在50ng和1000ng之间; 与所述打印装置相邻的电荷产生装置，以在所述生物活性剂上产生电荷以将所述生物活性剂吸引到所述可摄取基材; 与所述电荷产生装置相邻的冷流体去除装置，以从所述生物活性剂中除去所述可摄取载体流体的一部分; 与冷流体去除装置相邻的施加装置，以将可摄取层施加在可包含生物活性剂的可摄取基质的顶部上，或将可摄取基质折叠在包封生物活性剂的生物活性剂上; 以及与打印装置相邻的传送装置，电荷产生装置，冷流体去除装置和应用装置将可摄取的基板从一个装置移动到下一个装置。