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公开(公告)号：US20100137277A1
公开(公告)日：2010-06-03
申请号：US12522724
申请日：2008-01-11
申请人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson
发明人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson
IPC分类号： A61K31/397 , C07D401/04 , A61K31/4545 , A61P7/02 , A61K31/4439
CPC分类号： C07D401/04 , C07D413/14
摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备这些化合物的方法，其作为P2Y12抑制剂和抗血栓形成剂的用途，其作为心血管疾病中的药物的用途以及含有它们的药物组合物。
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公开(公告)号：US20080039437A1
公开(公告)日：2008-02-14
申请号：US11772269
申请日：2007-07-02
申请人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Lotta Jakobsson , Johan Johansson
发明人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Lotta Jakobsson , Johan Johansson
IPC分类号： A61K31/4545 , A61K31/4439 , C07D413/02 , C07D403/02
CPC分类号： C07D401/04 , C07D409/04 , C07D413/14
摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-thrombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备此类化合物的方法，其用途为P2Y 12 N抑制剂和作为抗血栓形成剂等，它们用作心血管疾病中的药物 以及含有它们的药物组合物。
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公开(公告)号：US20100069350A1
公开(公告)日：2010-03-18
申请号：US12307277
申请日：2007-07-02
申请人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Lotta Jakobsson , Johan Johansson
发明人： Thomas Antonsson , Peter Bach , David Brown , Ruth Bylund , Fabrizio Giordanetto , Lotta Jakobsson , Johan Johansson
IPC分类号： A61K31/445 , C07D211/06 , C07D401/04 , A61K31/4439 , A61K31/397 , A61P7/00
CPC分类号： C07D401/04 , C07D409/04 , C07D413/14
摘要： The present invention relates to certain new pyridin analogues of Formula (I), to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备此类化合物的方法，其用途为P2Y12抑制剂和抗血栓形成剂等，其用作心血管疾病中的药物以及含有它们的药物组合物 。
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公开(公告)号：US20080171732A1
公开(公告)日：2008-07-17
申请号：US11972831
申请日：2008-01-11
申请人： Thomas Antonsson , Ruth Bylund , Johan Johansson , Peter Bach , David Brown , Fabrizio Giordanetto
发明人： Thomas Antonsson , Ruth Bylund , Johan Johansson , Peter Bach , David Brown , Fabrizio Giordanetto
IPC分类号： A61K31/397 , C07D221/00 , A61K31/445 , A61P43/00 , A61K31/4523 , C07D213/02
CPC分类号： C07D401/04 , C07D413/14
摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备此类化合物的方法，其用途为P2Y 12 N抑制剂和抗血栓形成剂等，它们用作心血管疾病中的药物 以及含有它们的药物组合物。
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公开(公告)号：US20080200448A1
公开(公告)日：2008-08-21
申请号：US11972876
申请日：2008-01-11
申请人： Thomas Antonsson , Peter Bach , Kay Brickmann , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson , Fredrik Zetterberg
发明人： Thomas Antonsson , Peter Bach , Kay Brickmann , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson , Fredrik Zetterberg
IPC分类号： A61K31/4427 , C07D401/04 , A61K31/4439 , A61K31/4545 , A61P7/02
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07F7/0812
摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备此类化合物的方法，其用途为P2Y 12 N抑制剂和抗血栓形成剂等，它们用作心血管疾病中的药物 以及含有它们的药物组合物。
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公开(公告)号：US20080176827A1
公开(公告)日：2008-07-24
申请号：US11972654
申请日：2008-01-11
申请人： Thomas Antonsson , Peter Bach , Kay Brickmann , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson , Fredrik Zetterberg
发明人： Thomas Antonsson , Peter Bach , Kay Brickmann , Ruth Bylund , Fabrizio Giordanetto , Johan Johansson , Fredrik Zetterberg
IPC分类号： A61K31/397 , C07D211/00 , A61K31/445 , C07D401/04 , A61P9/00 , A61K31/4439 , A61K31/4427
CPC分类号： C07D401/04
摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备此类化合物的方法，其用途为P2Y 12 N抑制剂和抗血栓形成剂等，它们用作心血管疾病中的药物 以及含有它们的药物组合物。
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公开(公告)号：US20090018166A1
公开(公告)日：2009-01-15
申请号：US11972787
申请日：2008-01-11
申请人： Kosrat Amin , Thomas Antonsson , Christoffer Bengtsson , David Brown , Ruth Bylund , Daniel Hovdal , Fabrizio Giordanetto , Johan Johansson
发明人： Kosrat Amin , Thomas Antonsson , Christoffer Bengtsson , David Brown , Ruth Bylund , Daniel Hovdal , Fabrizio Giordanetto , Johan Johansson
IPC分类号： A61K31/4545 , C07D401/04
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14
摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备这些化合物的方法，其用作P2Y12抑制剂和抗血栓形成剂等，它们作为心血管疾病中的药物的用途以及含有它们的药物组合物。
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公开(公告)号：US06221898B1
公开(公告)日：2001-04-24
申请号：US08894833
申请日：1997-08-29
申请人： Thomas Antonsson
发明人： Thomas Antonsson
IPC分类号： A61K3138
CPC分类号： C07D333/34 , C07C309/73 , C07C311/21 , C07C311/29 , C07C323/60 , C07D233/84 , C07D261/16 , C07F9/5304
摘要： There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译： 提供式I化合物，其中R 1，R 2，R 3，Y，n和B具有在描述中给出的含义，其可用作胰蛋白酶样蛋白酶如凝血酶的竞争性抑制剂，特别是用于治疗条件 需要抑制凝血酶（如血栓形成）或作为抗凝剂。
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公开(公告)号：US07074820B2
公开(公告)日：2006-07-11
申请号：US09839609
申请日：2001-04-23
申请人： Thomas Antonsson
发明人： Thomas Antonsson
IPC分类号： A01N43/06
CPC分类号： C07D333/34 , C07C309/73 , C07C311/21 , C07C311/29 , C07C323/60 , C07D233/84 , C07D261/16 , C07F9/5304
摘要： There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译： 提供式I化合物，其中R 1，R 2，R 3，Y，n和B具有在说明书中给出的含义 其可用作胰蛋白酶样蛋白酶（例如凝血酶）的竞争性抑制剂，特别是用于治疗需要凝血酶抑制（例如血栓形成）或作为抗凝剂的条件。
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公开(公告)号：US07354905B2
公开(公告)日：2008-04-08
申请号：US10776245
申请日：2004-02-12
申请人： Thomas Antonsson , David Gustafsson , Kurt-Jürgen Hoffmann , Jan-Erik Nyström , Henrik Sörensen , Mikael Sellén
发明人： Thomas Antonsson , David Gustafsson , Kurt-Jürgen Hoffmann , Jan-Erik Nyström , Henrik Sörensen , Mikael Sellén
CPC分类号： C07D487/04 , A61K38/00 , C07D491/04 , C07D495/04 , C07K5/0222 , C07K5/06078
摘要： There is provided compounds of formula I, R1O(O)C—CH2—(R)Cgl-Aze-Pab-R2I wherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.
摘要翻译： 提供式I的化合物，<？在线公式描述=“在线式”end =“lead”→R 1 O（O）C-CH 2 （R）Cgl-Aze-Pab-R 在线公式描述=“在线公式”end =“尾”→其中R 1和R 2具有描述中给出的含义，其可用作胰蛋白酶样蛋白酶抑制剂如凝血酶的前药，特别是在治疗抑制 需要凝血酶（如血栓形成）或作为抗凝剂。
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