公开(公告)号：US20050267342A1

公开(公告)日：2005-12-01

申请号：US11117104

申请日：2005-04-27

申请人： Thomas Blank ,  George Acosta ,  Timothy Ruchti ,  Mutua Mattu ,  Alexander Lorenz ,  Kevin Hazen ,  James Henderson

发明人： Thomas Blank ,  George Acosta ,  Timothy Ruchti ,  Mutua Mattu ,  Alexander Lorenz ,  Kevin Hazen ,  James Henderson

IPC分类号： A61B5/00 ,  G01N21/35

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/4869 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2562/0242 ,  G01N21/359

摘要： A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.

摘要翻译： 提供了一种用于无创采样的方法和装置。 更具体地，该方法和装置涉及光学样本探针界面相对于组织样本位点的运动的控制。 使用动态探针接口来收集目标样品的光谱，根据x-，y-和z-轴中的至少一个来控​​制样品探针相对于组织样品的定位和/或样品的控制 组织位移以最小化由采样过程导致的频谱变化，并增加分析物质的估计精度和精度。

公开(公告)号：US20050203359A1

公开(公告)日：2005-09-15

申请号：US11008001

申请日：2004-12-08

申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti ,  Kevin Hazen ,  Donovan Berry ,  Roxanne Abul-Haj

发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti ,  Kevin Hazen ,  Donovan Berry ,  Roxanne Abul-Haj

IPC分类号： A61B5/00 ,  G01N21/35

CPC分类号： G01N21/359 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6833

摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.

摘要翻译： 公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。 本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导 控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。 可选组件包括闭塞元件和耦合流体。

公开(公告)号：US20060211927A1

公开(公告)日：2006-09-21

申请号：US11328543

申请日：2006-01-09

申请人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/6833 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/726 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0252 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2560/0456 ,  A61B2562/0242 ,  A61B2562/146 ,  A61B2562/227 ,  A61B2562/228 ,  G01N21/359 ,  G01N21/49

摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.

公开(公告)号：US20050107676A1

公开(公告)日：2005-05-19

申请号：US10971447

申请日：2004-10-21

申请人： George Acosta ,  James Henderson ,  N. Abul-Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Abul-Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223 ,  A61B2560/0233

摘要： A near-infrared spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and is used to collect spectral measurements of a tissue sample. The spectral readings are used to estimate a biological parameter in the sampled tissue noninvasively, such as glucose concentration. The preferred apparatus is a near-infrared analyzer that includes a base module and a sample module connected together with a communication bundle. The base module contains the bulk of the analyzer, such as a spectrograph and a central processing unit with an algorithm used for converting the optical signal into a glucose concentration. The sample module is typically in a smaller module that interfaces to a tissue sample. The sample module is preferably handheld and provides minimal sampling distortion due to heat or pressure.

摘要翻译： 基于近红外光谱仪的分析仪连续地或半连续地连接到人类受试者，并用于收集组织样本的光谱测量。 光谱读数用于非侵入性地估计采样组织中的生物学参数，如葡萄糖浓度。 优选的装置是近红外分析器，其包括与通信束连接在一起的基本模块和样本模块。 基本模块包含分析仪的大部分，例如光谱仪和具有用于将光信号转换为葡萄糖浓度的算法的中央处理单元。 样品模块通常在与组织样品接口的较小模块中。 样品模块优选是手持式的，并且由于热或压力而提供最小的采样失真。

公开(公告)号：US20060195023A1

公开(公告)日：2006-08-31

申请号：US11326958

申请日：2006-01-05

申请人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/6833 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/726 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0252 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2560/0456 ,  A61B2562/0242 ,  A61B2562/146 ,  A61B2562/227 ,  A61B2562/228 ,  G01N21/359 ,  G01N21/49

摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.

公开(公告)号：US20060116562A1

公开(公告)日：2006-06-01

申请号：US11335067

申请日：2006-01-18

申请人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/6833 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/726 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0252 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2560/0456 ,  A61B2562/0242 ,  A61B2562/146 ,  A61B2562/227 ,  A61B2562/228 ,  G01N21/359 ,  G01N21/49

摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.

摘要翻译： 本发明涉及通过紧凑型分析仪监测生物参数。 优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。 优选的目标分析物是葡萄糖。 优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

公开(公告)号：US20060183983A1

公开(公告)日：2006-08-17

申请号：US11335773

申请日：2006-01-18

申请人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/6833 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/726 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0252 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2560/0456 ,  A61B2562/0242 ,  A61B2562/146 ,  A61B2562/227 ,  A61B2562/228 ,  G01N21/359 ,  G01N21/49

摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.

公开(公告)号：US20060173255A1

公开(公告)日：2006-08-03

申请号：US11328902

申请日：2006-01-09

申请人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Abul Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/6833 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/726 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0252 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2560/0456 ,  A61B2562/0242 ,  A61B2562/146 ,  A61B2562/227 ,  A61B2562/228 ,  G01N21/359 ,  G01N21/49

摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.

公开(公告)号：US20060173254A1

公开(公告)日：2006-08-03

申请号：US11324876

申请日：2006-01-03

申请人： George Acosta ,  James Henderson ,  N. Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/6833 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/726 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0252 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2560/0456 ,  A61B2562/0242 ,  A61B2562/146 ,  A61B2562/227 ,  A61B2562/228 ,  G01N21/359 ,  G01N21/49

摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.

公开(公告)号：US20050020892A1

公开(公告)日：2005-01-27

申请号：US10820322

申请日：2004-04-07

申请人： George Acosta ,  James Henderson ,  N. Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

发明人： George Acosta ,  James Henderson ,  N. Haj ,  Timothy Ruchti ,  Stephen Monfre ,  Thomas Blank ,  Kevin Hazen

IPC分类号： A61B5/00 ,  A61B5/103 ,  A61B5/107 ,  G01N21/35 ,  G01N21/47 ,  G01N21/49

CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/441 ,  A61B5/4869 ,  A61B5/4872 ,  A61B5/6824 ,  A61B5/7203 ,  A61B5/726 ,  A61B2560/0233 ,  A61B2562/0233 ,  A61B2562/0242 ,  G01N21/359 ,  G01N21/474 ,  G01N21/49

摘要： A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneous layer of the sampled tissue so that interference from the adipose layer is minimized. The optical system includes at least one optical probe. Spacing between optical paths and detection fibers of each probe and between probes is optimized to minimize sampling of the adipose subcutaneous layer and to maximize collection of light backscattered from the cutaneous layer. Penetration depth is optimized by limiting range of distances between paths and detection fibers. Minimizing sampling of the adipose layer greatly reduces interference contributed by the fat band in the sample spectrum, increasing signal-to-noise ratio. Providing multiple probes also minimizes interference in the sample spectrum due to placement errors.

摘要翻译： 基于近红外光谱仪的分析仪连续或半连续地连接到人类受试者并且收集用于确定采样组织中的生物学参数（诸如葡萄糖浓度）的光谱测量。 该分析仪包括优化的靶向采样组织的皮肤层的光学系统，使得来自脂肪层的干扰最小化。 光学系统包括至少一个光学探针。 针对每个探针和探针之间的光路和检测纤维之间的间距进行优化，以最小化脂肪皮下层的取样，并最大限度地收集从皮肤层反射的光。 穿透深度通过限制路径和检测光纤之间的距离范围进行优化。 最小化脂肪层的取样大大减少了样品谱中脂肪带所造成的干扰，提高了信噪比。 提供多个探针也可以最小化由于放置误差而导致的样品光谱干扰。