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    Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy and halogen-substituted spirocyclic ketoenols
    7.
    发明授权
    Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy and halogen-substituted spirocyclic ketoenols 有权
    取代的3-（联苯-3-基）-8,8-二氟-4-羟基-1-氮杂螺[4.5]癸-3-烯-2-酮用于治疗和卤素取代的螺环酮醇

    公开(公告)号：US08946124B2

    公开(公告)日：2015-02-03

    申请号：US14000147

    申请日：2012-02-14

    申请人： Thomas Bretschneider ,  Reiner Fischer ,  Stefan Lehr ,  Elmar Gatzweiler ,  Ulrich Görgens ,  Isolde Häuser-Hahn ,  Ines Heinemann ,  Arnd Voerste

    发明人： Thomas Bretschneider ,  Reiner Fischer ,  Stefan Lehr ,  Elmar Gatzweiler ,  Ulrich Görgens ,  Isolde Häuser-Hahn ,  Ines Heinemann ,  Arnd Voerste

    IPC分类号： A01N43/08 ,  A01N43/38 ,  C07D209/54 ,  C07D307/94 ,  A61K31/403 ,  A61K45/06 ,  A01N43/12

    CPC分类号： A01N43/38 ,  A01N43/12 ,  A61K31/403 ,  A61K45/06 ,  C07D209/54

    摘要： The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. The invention also relates to selective herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound.The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth.The invention also relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumor disorders.

    摘要翻译： 本发明涉及其中W，X，Y，Z，A，B，D和G具有上述含义的式（I）的新化合物与多种制备方法和中间体及其用途 作为农药和/或除草剂和/或杀真菌剂。 本发明还涉及选择性除草组合物，其包含首先是卤素取代的螺环酮醇，其次是作物植物相容性改善化合物。 本发明还涉及通过将铵盐或鏻盐和任选的渗透剂加入到相应的组合物中来增强作物保护组合物的作用，包括特别是卤素取代的螺环酮醇，制备它们的方法和 在农作物保护中作为农药和/或杀真菌剂的应用和/或用于防止不期望的植物生长。 本发明还涉及用于治疗目的的式（Ia）的取代的3-（联苯-3-基）-8,8-二氟-4-羟基-1-氮杂螺[4.5]癸-3-烯-2-酮 ，药物组合物及其在治疗中的用途，特别是用于预防和治疗肿瘤病症。