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1.发明申请Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号：US20050025765A1
公开(公告)日：2005-02-03
申请号：US10630227
申请日：2003-07-30
申请人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Martin Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
发明人： Thomas DiMauro , Mohamed Attawia , Hassan Serhan , Martin Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K31/198 , A61K31/436 , A61K38/18 , A61K38/30 , A61P19/02 , A61K39/395 , A61K38/17
CPC分类号： A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要： The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译： 本发明涉及向患病关节中透射施用高特异性拮抗剂，所述高特异性拮抗剂选自：i）促炎白细胞介素的抑制剂; ii）TNF-α合成抑制剂; iii）膜结合TNF-α的抑制剂; iv）TNF-α的天然受体的抑制剂; v）NO合酶抑制剂，vi）PLA2酶抑制剂; vii）抗增殖剂; viii）抗氧化剂; ix）选自EPO模拟肽，EPO模拟物，IGF-I，IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂，和x）MMP的抑制剂; 和xi）p38激酶的抑制剂。
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公开(公告)号：US20050038001A1
公开(公告)日：2005-02-17
申请号：US10640412
申请日：2003-08-13
申请人： Mohamed Attawia , Thomas DiMauro , Hassan Serhan , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
发明人： Mohamed Attawia , Thomas DiMauro , Hassan Serhan , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura Brown , Jeff Geesin , Pamela Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： The present invention relates to injecting a cycline compound into a diseased intervertebral disc.
摘要翻译： 本发明涉及将环状化合物注射到患病的椎间盘中。
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3.发明授权Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号：US08361467B2
公开(公告)日：2013-01-29
申请号：US10630227
申请日：2003-07-30
申请人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人： Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号： A61K39/395 , A61K39/00 , A61K38/18
CPC分类号： A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要： The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译： 本发明涉及向患病关节中透射施用高特异性拮抗剂，所述高特异性拮抗剂选自：i）促炎白细胞介素的抑制剂; ii）TNF-α合成抑制剂; iii）膜结合TNF-α的抑制剂; iv）TNF-α的天然受体的抑制剂; v）NO合酶抑制剂，vi）PLA2酶抑制剂; vii）抗增殖剂; viii）抗氧化剂; ix）选自EPO模拟肽，EPO模拟物，IGF-I，IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂，和x）MMP的抑制剂; 和xi）p38激酶的抑制剂。
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4.发明授权Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号：US08728523B2
公开(公告)日：2014-05-20
申请号：US12291378
申请日：2008-11-07
申请人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号： A61K45/00 , A61K39/395
CPC分类号： A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要： The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译： 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号：US07553827B2
公开(公告)日：2009-06-30
申请号：US10640412
申请日：2003-08-13
申请人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
发明人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , A61K38/20 , A61K45/06 , A61K2300/00
摘要： The present invention relates to injecting a cycline compound into a diseased intervertebral disc.
摘要翻译： 本发明涉及将环状化合物注射到患病的椎间盘中。
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6.发明申请Transdiscal administration of anti-TNFalpha antibodies and growth differentiation factors 有权抗TNFalpha抗体和生长分化因子的经半径给药公开(公告)号：US20090155364A1
公开(公告)日：2009-06-18
申请号：US12290998
申请日：2008-11-05
申请人： Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人： Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号： A61K9/10 , A61K39/395
CPC分类号： A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要： The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译： 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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7.发明授权Transdiscal administration of anti-TNFα antibodies and growth differentiation factors 有权反式TNFα抗体和生长分化因子的经半径给药公开(公告)号：US08877193B2
公开(公告)日：2014-11-04
申请号：US12290998
申请日：2008-11-05
申请人： Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人： Hassan Serhan , Mohamed Attawia , Thomas M. DiMauro , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号： A61K39/00 , A61K39/395 , A61K38/17
CPC分类号： A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要： The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译： 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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8.发明申请Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号：US20090175943A1
公开(公告)日：2009-07-09
申请号：US12291378
申请日：2008-11-07
申请人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人： Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号： A61K9/10 , A61K39/395
CPC分类号： A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要： The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译： 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号：US07429378B2
公开(公告)日：2008-09-30
申请号：US10610355
申请日：2003-06-30
申请人： Hassan Serhan , Thomas M. DiMauro , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
发明人： Hassan Serhan , Thomas M. DiMauro , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Laura J. Brown , Jeffrey C. Geesin
IPC分类号： A61K35/00
CPC分类号： A61K38/1841 , A61K35/28 , A61K38/57 , A61K2300/00
摘要： The present invention relates to injecting a high affinity antagonist of MMPs into a diseased intervertebral disc.
摘要翻译： 本发明涉及将MMP的高亲和力拮抗剂注射到患病的椎间盘中。
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公开(公告)号：US20080213261A1
公开(公告)日：2008-09-04
申请号：US11881926
申请日：2007-07-30
申请人： Thomas M. DiMauro , Hassan Serhan , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人： Thomas M. DiMauro , Hassan Serhan , Mohamed Attawia , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号： A61K39/395 , A61K35/00 , A61P19/00 , A61K35/12
CPC分类号： A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要： The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
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