公开(公告)号：US08509896B2

公开(公告)日：2013-08-13

申请号：US12269746

申请日：2008-11-12

申请人： Thomas Doerr ,  Dirk Muessig ,  Volker Lang

发明人： Thomas Doerr ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/3688

摘要： An implantable cardiac stimulator (10), configured to switch mode of operation between at least one right ventricular stimulation mode in which no control signals triggering left ventricular stimulation pulses are delivered to the left ventricular stimulation unit and a biventricular stimulation mode in alternation. Switching takes place as a function of duration of prevailing QRS signal interval, such that the cardiac stimulator switches to biventricular stimulation mode when comparison of the duration of a prevailing QRS signal interval with a first comparison value reveals the duration of the prevailing QRS signal interval is longer than a first reference value represented by the first comparison value and switches to right ventricular stimulation mode when comparison of the duration of a prevailing QRS signal interval with a second comparison value reveals the duration of the prevailing QRS signal interval is shorter than a second reference value represented by the second comparison value.

摘要翻译： 可植入心脏刺激器（10），被配置为在不将控制信号触发左心室刺激脉冲输送到左心室刺激单元的至少一个右心室刺激模式和交替的双心室刺激模式之间切换操作模式。 根据当前的QRS信号间隔的持续时间进行切换，使得当主要QRS信号间隔与第一比较值的持续时间比较时心脏刺激器切换到双心室刺激模式，显示当前QRS信号间隔的持续时间为 比由第一比较值表示的第一参考值长，并且当比较主要QRS信号间隔与第二比较值的持续时间时，切换到右心室刺激模式，显示当前QRS信号间隔的持续时间短于第二参考 值由第二比较值表示。

公开(公告)号：US20090125077A1

公开(公告)日：2009-05-14

申请号：US12269746

申请日：2008-11-12

申请人： Thomas DOERR ,  Dirk Muessig ,  Volker Lang

发明人： Thomas DOERR ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/3688

摘要： An implantable cardiac stimulator (10), configured to switch mode of operation between at least one right ventricular stimulation mode in which no control signals triggering left ventricular stimulation pulses are delivered to the left ventricular stimulation unit and a biventricular stimulation mode in alternation. Switching takes place as a function of duration of prevailing QRS signal interval, such that the cardiac stimulator switches to biventricular stimulation mode when comparison of the duration of a prevailing QRS signal interval with a first comparison value reveals the duration of the prevailing QRS signal interval is longer than a first reference value represented by the first comparison value and switches to right ventricular stimulation mode when comparison of the duration of a prevailing QRS signal interval with a second comparison value reveals the duration of the prevailing QRS signal interval is shorter than a second reference value represented by the second comparison value.

摘要翻译： 可植入心脏刺激器（10），被配置为在不将控制信号触发左心室刺激脉冲输送到左心室刺激单元的至少一个右心室刺激模式和交替的双心室刺激模式之间切换操作模式。 根据当前的QRS信号间隔的持续时间进行切换，使得当主要QRS信号间隔与第一比较值的持续时间比较时心脏刺激器切换到双心室刺激模式，显示当前QRS信号间隔的持续时间为 比由第一比较值表示的第一参考值长，并且当比较主要QRS信号间隔与第二比较值的持续时间时，切换到右心室刺激模式，显示当前QRS信号间隔的持续时间短于第二参考 值由第二比较值表示。

公开(公告)号：US08843198B2

公开(公告)日：2014-09-23

申请号：US13603418

申请日：2012-09-05

申请人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/368 ,  A61B5/04 ,  A61N1/365 ,  A61N1/362 ,  A61B5/0402

CPC分类号： A61N1/3627 ,  A61B5/0402 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

摘要： The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.

摘要翻译： 本公开涉及包括刺激控制单元，刺激单元，阻抗测量单元和阻抗评估单元的心脏刺激器。 刺激控制单元可操作地连接到刺激单元以控制所述刺激单元的刺激脉冲的定时。 阻抗测量单元被配置为确定反映心内阻抗的阻抗信号。 阻抗评估单元可操作地连接到阻抗测量单元和刺激控制单元，并被配置为评估阻抗信号，以便确定等容收缩时间，等容弛豫时间，喷射时间和来自所述阻抗的填充时间 信号。 刺激控制单元还被配置为根据性能指标来控制刺激脉冲的定时。

公开(公告)号：US08380307B2

公开(公告)日：2013-02-19

申请号：US12255516

申请日：2008-10-21

申请人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

发明人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/3688

摘要： The invention is directed to a heart stimulator for left-ventricular pacing comprising a left ventricular stimulation pulse generator connected or connectable to a single electrode lead for left ventricular stimulation having one or more electrodes for delivery of stimulation pulses to left ventricular myocardial heart tissue, said stimulation pulse generator being adapted to generate and deliver stimulation pulses of switchable polarity. The heart stimulator further comprises a control unit connected to the stimulation pulse generator for controlling the stimulation pulse generator and to trigger generation and delivery of stimulation pulses having a polarity controlled by said control unit, wherein the control unit is adapted to control said left ventricular stimulation pulse generator so as to deliver at least a pair of suprathreshold stimulation pulses of opposite polarity.

摘要翻译： 本发明涉及用于左心室起搏的心脏刺激器，其包括连接或可连接到用于左心室刺激的单个电极引线的左心室刺激脉冲发生器，其具有用于将刺激脉冲递送至左心室心肌心脏组织的一个或多个电极，所述左心室起搏器 刺激脉冲发生器适于产生和递送可切换极性的刺激脉冲。 心脏刺激器还包括连接到刺激脉冲发生器的控制单元，用于控制刺激脉冲发生器并触发具有由所述控制单元控制的极性的刺激脉冲的产生和传递，其中控制单元适于控制所述左心室刺激 以产生相反极性的至少一对超阈值刺激脉冲。

公开(公告)号：US07899520B2

公开(公告)日：2011-03-01

申请号：US12124499

申请日：2008-05-21

申请人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

发明人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61B5/04

CPC分类号： G06K9/00496 ,  A61N1/3684 ,  A61N1/3712 ,  G06K9/00536

摘要： A medical device having a sensor for sampling a biological signal, the biological signal representing a signal waveform and forming a waveform vector composed of the biological signal samples, and a memory for storing a least two threshold vectors composed of boundary samples representing at least two boundaries related to the biological signal defining subspaces for the biological signal samples. One threshold vector is an upper threshold vector composed of upper boundary samples and the other threshold vector is a lower threshold vector composed of lower boundary samples. An evaluation unit connected to the sensor determines a similarity index (ASCI) by comparing each of the biological signal samples of the waveform vector to corresponding boundary samples of the threshold vectors, thus determining to which subspace each biological signal sample belongs to and creating a trichotomized signal vector, and calculating the signed correlation product of two trichotomized signal vectors.

摘要翻译： 一种具有用于对生物体信号进行采样的传感器的医疗装置，生物信号表示信号波形并形成由生物信号样本构成的波形矢量，以及存储器，用于存储由表示至少两个边界的边界样本组成的至少两个阈值向量 与生物信号样品的生物信号定义子空间有关。 一个阈值向量是由上边界样本组成的上阈值向量，另一阈值向量是由下边界样本组成的下阈值向量。 连接到传感器的评估单元通过将波形向量的生物信号样本与阈值向量的相应边界样本进行比较来确定相似性指数（ASCI），从而确定每个生物信号样本属于哪个子空间并创建三分法 信号向量，并计算两个三分信号向量的有符号相关乘积。

公开(公告)号：US20080294217A1

公开(公告)日：2008-11-27

申请号：US12124499

申请日：2008-05-21

申请人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

发明人： Jie Lian ,  Garth Garner ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/368 ,  A61B5/00

CPC分类号： G06K9/00496 ,  A61N1/3684 ,  A61N1/3712 ,  G06K9/00536

摘要： A medical device having a sensor for sampling a biological signal, the biological signal representing a signal waveform and forming a waveform vector composed of the biological signal samples, and a memory for storing a least two threshold vectors composed of boundary samples representing at least two boundaries related to the biological signal defining subspaces for the biological signal samples. One threshold vector is an upper threshold vector composed of upper boundary samples and the other threshold vector is a lower threshold vector composed of lower boundary samples. An evaluation unit connected to the sensor determines a similarity index (ASCI) by comparing each of the biological signal samples of the waveform vector to corresponding boundary samples of the threshold vectors, thus determining to which subspace each biological signal sample belongs to and creating a trichotomized signal vector, and calculating the signed correlation product of two trichotomized signal vectors.

摘要翻译： 一种具有用于对生物体信号进行采样的传感器的医疗装置，生物信号表示信号波形并形成由生物信号样本构成的波形矢量，以及存储器，用于存储由表示至少两个边界的边界样本组成的至少两个阈值向量 与生物信号样品的生物信号定义子空间有关。 一个阈值向量是由上边界样本组成的上阈值向量，另一个阈值向量是由下边界样本组成的下阈值向量。 连接到传感器的评估单元通过将波形向量的生物信号样本与阈值向量的相应边界样本进行比较来确定相似性指数（ASCI），从而确定每个生物信号样本属于哪个子空间并创建三分法 信号矢量，并计算两个三分信号矢量的有符号相关乘积。

公开(公告)号：US20080114411A1

公开(公告)日：2008-05-15

申请号：US11560141

申请日：2006-11-15

申请人： Jie Lian ,  Dirk Muessig ,  Volker Lang

发明人： Jie Lian ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/365

CPC分类号： A61N1/3621 ,  A61B5/0452

摘要： Heart stimulator that provides for timing a premature stimulation pulse for anti-tachycardia pacing outside the vulnerable phase of a ventricle, to terminate stable ventricular tachycardia while minimizing the risk of accelerating stable ventricular tachycardia into unstable ventricular tachycardia or ventricular fibrillation. RT interval is determined instead of QT interval. Conventional QT interval is defined to end at T wave offset, which is difficult to measure because inherent imprecision in identifying the end of T wave from surface ECG. For safe ATP, such problems may be avoided. Because the VP usually refers to the portion of the T wave near the peak and early downslope (FIG. 3), in order to avoid the VP, only need to determine the peak of T wave, then set an blanking window or safety margin (e.g., 20 ms before to 20 ms after the peak of T wave) during which ATP pulses should not be delivered.

摘要翻译： 心脏刺激器提供定时的过早刺激脉冲，用于在心室易失性阶段之外的抗心动过速起搏，以终止稳定的室性心动过速，同时最小化加速稳定性室性心动过速到不稳定室性心动过速或心室纤维性颤动的风险。 确定RT间隔而不是QT间隔。 常规QT间隔被定义为在T波偏移处结束，这是难以测量的，因为在从表面ECG识别T波的末端的固有的不精确性。 为了安全的ATP，可以避免这样的问题。 因为VP通常是指峰值附近的T波的一部分和早期的下坡（图3），为了避免VP，只需要确定T波的峰值，则设置消隐窗口或安全裕度（ 例如，在T波峰值之前到20ms之前20ms），其中不应该递送ATP脉冲。

公开(公告)号：US20130079839A1

公开(公告)日：2013-03-28

申请号：US13603418

申请日：2012-09-05

申请人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Volker Lang ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/0402 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3686

摘要： The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.

摘要翻译： 本公开涉及包括刺激控制单元，刺激单元，阻抗测量单元和阻抗评估单元的心脏刺激器。 刺激控制单元可操作地连接到刺激单元以控制所述刺激单元的刺激脉冲的定时。 阻抗测量单元被配置为确定反映心内阻抗的阻抗信号。 阻抗评估单元可操作地连接到阻抗测量单元和刺激控制单元，并被配置为评估阻抗信号，以便确定等容收缩时间，等容弛豫时间，喷射时间和来自所述阻抗的填充时间 信号。 刺激控制单元还被配置为根据性能指标来控制刺激脉冲的定时。

公开(公告)号：US08019406B2

公开(公告)日：2011-09-13

申请号：US12045142

申请日：2008-03-10

申请人： Jie Lian ,  Dirk Muessig ,  Volker Lang

发明人： Jie Lian ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61N1/362 ,  A61B5/0452

CPC分类号： A61B5/04011 ,  A61B5/0452 ,  A61B5/7275 ,  A61N1/3622 ,  A61N1/37282 ,  G06F19/00

摘要： A medical device and a method is suggested for assessing the risk of R on T events. The device comprises a memory, input means for acquiring or receiving an electrogram signal and processing means. The processing means are adapted to detect R-wave and T-waves represented by said electrogram, establish a QT-RR regression model based detected R-waves and T-waves, estimate a vulnerable period, and store estimated vulnerable period data in said memory. Likewise, the method comprises the steps of to detecting R-wave and T-waves represented by an electrogram, establishing a QT-RR regression model based detected R-waves and T-waves, estimating a vulnerable period, and storing estimated vulnerable period data.

摘要翻译： 建议使用医疗设备和方法来评估R on T事件的风险。 该装置包括存储器，用于获取或接收电描记图信号的输入装置和处理装置。 处理装置适于检测由所述电描记图表示的R波和T波，建立基于检测到的R波和T波的QT-RR回归模型，估计易受伤害的周期，并将估计的脆弱周期数据存储在所述存储器中 。 同样地，该方法包括以下步骤：检测由电描记图表示的R波和T波，建立基于检测的R波和T波的QT-RR回归模型，估计脆弱时期，以及存储估计的脆弱周期数据 。

公开(公告)号：US20100217143A1

公开(公告)日：2010-08-26

申请号：US12391208

申请日：2009-02-23

申请人： Hollis Whittington ,  Dirk Muessig ,  Volker Lang

发明人： Hollis Whittington ,  Dirk Muessig ,  Volker Lang

IPC分类号： A61B5/0408

CPC分类号： A61B5/7207 ,  A61B5/042 ,  A61B5/0428 ,  A61B5/7221 ,  A61N1/3684

摘要： A medical device for processing physiological signals such as electrocardiograms. The processing includes: sampling a physiologic signal in a first channel with a first sampling rate, simultaneously sampling the physiologic signal in a second channel with a higher sampling rate to thus generate pairs of sampling values, forming the difference between two sampling values of each pair, comparing said difference with a threshold, and generating a noise detection indicator whenever said threshold is exceeded.

摘要翻译： 用于处理诸如心电图之类的生理信号的医疗装置。 该处理包括：以第一采样率对第一通道中的生理信号进行采样，同时以较高的采样速率对第二通道中的生理信号进行采样，从而产生成对的采样值，形成两对采样值之间的差值 将所述差异与阈值进行比较，并且每当超过所述阈值时产生噪声检测指示符。