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1.发明授权Process for the preparation of 3-(methylthio) propanal and 2-hydroxy-4-(methylthio) butanenitrile 失效制备3-（甲硫基）丙醛和2-羟基-4-（甲硫基）丁腈的方法
公开(公告)号：US5663409A
公开(公告)日：1997-09-02
申请号：US476356
申请日：1995-06-07
IPC分类号： C07C319/18 , C07C319/20 , C07C323/22 , C07C323/60 , C07C253/30 , C07C253/00
CPC分类号： C07C319/20 , C07C319/18
摘要： Catalytic processes for the preparation of 3-(methylthio)propanal and 2-hydroxy-4-(methylthio)butanenitrile using novel addition catalysts are disclosed. The novel addition catalysts include: nicotinamide, imidazole, benzimidazole, 2-fluoropyridine, poly-4-vinylpyridine, 4-dimethylaminopyridine, picoline and pyrazine.
摘要翻译： 公开了使用新型加成催化剂制备3-（甲硫基）丙醛和2-羟基-4-（甲硫基）丁腈的催化方法。 新型加成催化剂包括：烟酰胺，咪唑，苯并咪唑，2-氟吡啶，聚-4-乙烯基吡啶，4-二甲基氨基吡啶，甲基吡啶和吡嗪。
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2.发明授权Continuous hydrolysis process for the preparation of 2-hydroxy-4-methylthiobutanoic acid 失效用于制备2-羟基-4-甲硫基丁酸的连续水解方法公开(公告)号：US06458997B2
公开(公告)日：2002-10-01
申请号：US09748067
申请日：2000-12-22
IPC分类号： C07C5142
CPC分类号： B01J19/1837 , A23K20/105 , B01J14/00 , B01J19/18 , B01J19/1862 , B01J19/1881 , B01J19/24 , B01J19/243 , B01J19/2435 , B01J19/245 , B01J2219/00013 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/00099 , B01J2219/00103 , B01J2219/0011 , B01J2219/00166 , B01J2219/185 , C07C319/18 , C07C319/20 , C07C323/52 , C07C323/60
摘要： A continuous process for the preparation of 2-hydroxy-4-methylthiobutanoic acid which includes introducing sulfuric acid into a first reactor including a continuous stirred tank reactor and introducing 2-hydroxy-4-methylthiobutanenitrile into the first reactor. 2-hydroxy-4-methylthiobutanenitrile is continually hydrolyzed within the first reactor to produce an intermediate aqueous hydrolysis solution containing 2-hydroxy-4-methylthiobutanamide. The intermediate aqueous hydrolysis solution is continuously introduced into a plug flow reactor. 2-hydroxy-4-methylthiobutanamide is continually hydrolyzed within the plug flow reactor to produce an aqueous hydrolyzate product solution containing 2-hydroxy-4-methylthiobutanoic acid. 2-hydroxy-4-methylthiobutanoic acid is recovered from the aqueous hydrolyzate product solution.
摘要翻译： 一种用于制备2-羟基-4-甲硫基丁酸的连续方法，其包括将硫酸引入到包括连续搅拌釜反应器的第一反应器中并将2-羟基-4-甲硫基丁腈引入第一反应器中。 2-羟基-4-甲硫基丁腈在第一反应器内连续水解，得到含有2-羟基-4-甲硫基丁酰胺的中间水解水解溶液。 将中间水解水溶液连续引入活塞流反应器。 2-羟基-4-甲硫基丁酰胺在活塞流反应器内连续水解，生成含有2-羟基-4-甲硫基丁酸的含水解产物溶液。 从水解产物水溶液中回收2-羟基-4-甲基硫代丁酸。
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3.发明授权Processes for the preparation of 3-(methylthio)propanal and 2-hydroxy-4-(methylthio)butanenitrile 失效制备3-（甲硫基）丙醛和2-羟基-4-（甲硫基）丁腈的方法
公开(公告)号：US5705675A
公开(公告)日：1998-01-06
申请号：US581249
申请日：1995-12-29
IPC分类号： C07C319/18 , C07C319/20 , C07C323/22 , C07C323/60 , C07C253/00 , C07C253/30
CPC分类号： C07C319/20 , C07C319/18
摘要： Described herein is a catalytic processes for the preparation of 3-(methylthio)propanal and 2-hydroxy-4-(methylthio)butanenitrile using novel addition catalysts are disclosed. The novel addition catalysts include: triisopropanolamine, nicotinamide, imidazole, benzimidazole, 2-fluoropyridine, poly-4-vinylpyridine, 4-dimethylaminopyridine, picoline, pyrazine, trialkylamines having from three to eighteen carbon atoms in each of the alkyl substituents bonded to the nitrogen atom and tertiary amines having the formula ##STR1## wherein A is aryl, R.sub.1 and R.sub.2 are alkyl and x, a, b and c are integers such that 0.ltoreq.x.ltoreq.3, 1.ltoreq.a.ltoreq.3, 0.ltoreq.b.ltoreq.2, 0.ltoreq.c.ltoreq.2 provided that a+b+c=3.
摘要翻译： 本文描述了使用新型加成催化剂制备3-（甲硫基）丙醛和2-羟基-4-（甲硫基）丁腈的催化方法。 该新型加成催化剂包括：三异丙醇胺，烟酰胺，咪唑，苯并咪唑，2-氟吡啶，聚-4-乙烯基吡啶，4-二甲基氨基吡啶，甲基吡啶，吡嗪，在每个与氮键合的烷基取代基中具有3至18个碳原子的三烷基胺 具有式“IMAGE”的原子和叔胺其中A是芳基，R 1和R 2是烷基，x，a，b和c是整数，使得0≤x≤3,1， 3，0
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公开(公告)号：US06166250A
公开(公告)日：2000-12-26
申请号：US165806
申请日：1998-10-02
IPC分类号： A23K1/16 , B01J14/00 , B01J19/18 , B01J19/24 , C07C319/18 , C07C319/20 , C07C323/52 , C07C323/60 , C07C51/42 , C07C381/00
CPC分类号： B01J19/1837 , A23K20/105 , B01J14/00 , B01J19/18 , B01J19/1862 , B01J19/1881 , B01J19/24 , B01J19/243 , B01J19/2435 , B01J19/245 , B01J2219/00013 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/00099 , B01J2219/00103 , B01J2219/0011 , B01J2219/00166 , B01J2219/185 , C07C319/18 , C07C319/20 , C07C323/52 , C07C323/60
摘要： A continuous process for the preparation of 2-hydroxy-4-methylthiobutanoic acid which includes introducing sulfuric acid into a first reactor including a continuous stirred tank reactor and introducing 2-hydroxy-4-methylthiobutanenitrile into the first reactor. 2-hydroxy-4-methylthiobutanenitrile is continually hydrolyzed within the first reactor to produce an intermediate aqueous hydrolysis solution containing 2-hydroxy-4-methylthiobutanamide. The intermediate aqueous hydrolysis solution is continuously introduced into a plug flow reactor. 2-hydroxy-4-methylthiobutanamide is continually hydrolyzed within the plug flow reactor to produce an aqueous hydrolyzate product solution containing 2-hydroxy-4-methylthiobutanoic acid. 2-hydroxy-4-methylthiobutanoic acid is recovered from the aqueous hydrolyzate product solution.
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公开(公告)号：US5998664A
公开(公告)日：1999-12-07
申请号：US876011
申请日：1997-06-13
IPC分类号： A23K1/16 , B01J14/00 , B01J19/18 , B01J19/24 , C07C319/18 , C07C319/20 , C07C323/52 , C07C323/60 , C07C51/42 , C07C381/00
CPC分类号： B01J19/1837 , A23K20/105 , B01J14/00 , B01J19/18 , B01J19/1862 , B01J19/1881 , B01J19/24 , B01J19/243 , B01J19/2435 , B01J19/245 , C07C319/18 , C07C319/20 , B01J2219/00013 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/00099 , B01J2219/00103 , B01J2219/0011 , B01J2219/00166 , B01J2219/185
摘要： A continuous process for the preparation of 2-hydroxy-4-methylthiobutanoic acid which includes introducing sulfuric acid into a first reactor including a continuous stirred tank reactor and introducing 2-hydroxy-4-methylthiobutanenitrile into the first reactor. 2-hydroxy-4-methylthiobutanenitrile is continually hydrolyzed within the first reactor to produce an intermediate aqueous hydrolysis solution containing 2-hydroxy-4-methylthiobutanamide. The intermediate aqueous hydrolysis solution is continuously introduced into a plug flow reactor. 2-hydroxy-4-methylthiobutanamide is continually hydrolyzed within the plug flow reactor to produce an aqueous hydrolyzate product solution containing 2-hydroxy-4-methylthiobutanoic acid. 2-hydroxy-4-methylthiobutanoic acid is recovered from the aqueous hydrolyzate product solution.
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6.发明授权Continuous hydrolysis process for preparing 2-hydroxy-4-methylthiobutanoic acid or salts thereof 有权用于制备2-羟基-4-甲硫基丁酸或其盐的连续水解方法公开(公告)号：US06531101B2
公开(公告)日：2003-03-11
申请号：US09750584
申请日：2000-12-28
IPC分类号： B01J800
CPC分类号： B01J19/1837 , A23K20/105 , B01J14/00 , B01J19/18 , B01J19/1862 , B01J19/1881 , B01J19/24 , B01J19/243 , B01J19/2435 , B01J19/245 , B01J19/2465 , B01J2219/00013 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/00099 , B01J2219/00103 , B01J2219/0011 , B01J2219/00166 , B01J2219/185 , C07C319/20 , C07C323/60 , C07C323/52
摘要： A continuous process for the preparation of 2-hydroxy-4-methylthiobutanoic acid or a salt thereof which includes introducing an aqueous mineral acid into a nitrile hydrolysis reactor including a continuous stirred tank reactor and introducing 2-hydroxy-4-methylthiobutanenitrile into the nitrile hydrolysis reactor. 2-hydroxy-4-methylthiobutanenitrile is continually hydrolyzed within the nitrile hydrolysis reactor to produce a nitrile hydrolysis reactor product stream containing 2-hydroxy-4-methylthiobutanamide. The nitrile hydrolysis reactor product stream is continuously introduced into an amide hydrolysis flow reactor. 2-hydroxy-4-methylthiobutanamide is continually hydrolyzed within the amide hydrolysis flow reactor to produce an aqueous hydrolyzate product containing 2-hydroxy-4-methylthiobutanoic acid. 2-hydroxy-4-methylthiobutanoic acid is recovered from the aqueous hydrolyzate product.
摘要翻译： 一种用于制备2-羟基-4-甲硫基丁酸或其盐的连续方法，其包括将无机酸水溶液引入腈水解反应器，包括连续搅拌釜反应器并将2-羟基-4-甲硫基丁腈引入腈水解 反应堆。 在腈水解反应器内不断水解2-羟基-4-甲硫基丁腈，生成含有2-羟基-4-甲硫基丁酰胺的腈水解反应器产物流。 将腈水解反应器产物流连续引入酰胺水解流反应器。 2-氨基-4-甲硫基丁酰胺在酰胺水解流反应器内连续水解，得到含有2-羟基-4-甲硫基丁酸的含水解产物。 从水解产物水溶液中回收2-羟基-4-甲硫基丁酸。
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7.发明授权Continuous hydrolysis process for preparing 2-hydroxy-4-methylthiobutanoic acid or salts thereof 有权用于制备2-羟基-4-甲硫基丁酸或其盐的连续水解方法公开(公告)号：US06268531B1
公开(公告)日：2001-07-31
申请号：US09165819
申请日：1998-10-02
IPC分类号： C07C5142
CPC分类号： B01J19/1837 , A23K20/105 , B01J14/00 , B01J19/18 , B01J19/1862 , B01J19/1881 , B01J19/24 , B01J19/243 , B01J19/2435 , B01J19/245 , B01J19/2465 , B01J2219/00013 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/00099 , B01J2219/00103 , B01J2219/0011 , B01J2219/00166 , B01J2219/185 , C07C319/20 , C07C323/60 , C07C323/52
摘要： A continuous process for the preparation of 2-hydroxy-4-methylthiobutanoic acid or a salt thereof which includes introducing an aqueous mineral acid into a nitrile hydrolysis reactor including a continuous stirred tank reactor and introducing 2-hydroxy-4-methylthiobutanenitrile into the nitrile hydrolysis reactor. 2-hydroxy-4-methylthiobutanenitrile is continually hydrolyzed within the nitrile hydrolysis reactor to produce a nitrile hydrolysis reactor product stream containing 2-hydroxy-4-methylthiobutanamide. The nitrile hydrolysis reactor product stream is continuously introduced into an amide hydrolysis flow reactor. 2-hydroxy-4-methylthiobutanamide is continually hydrolyzed within the amide hydrolysis flow reactor to produce an aqueous hydrolyzate product containing 2-hydroxy-4-methylthiobutanoic acid. 2-hydroxy-4-methylthiobutanoic acid is recovered from the aqueous hydrolyzate product.
摘要翻译： 一种用于制备2-羟基-4-甲硫基丁酸或其盐的连续方法，其包括将无机酸水溶液引入腈水解反应器，包括连续搅拌釜反应器并将2-羟基-4-甲硫基丁腈引入腈水解 反应堆。 在腈水解反应器内连续水解2-羟基-4-甲硫基丁腈，生成含有2-羟基-4-甲硫基丁酰胺的腈水解反应器产物流。 将腈水解反应器产物流连续引入酰胺水解流反应器。 2-氨基-4-甲硫基丁酰胺在酰胺水解流反应器内连续水解，得到含有2-羟基-4-甲硫基丁酸的含水解产物。 从水解产物水溶液中回收2-羟基-4-甲硫基丁酸。
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8.发明授权Continuous hydrolysis process for preparing 2-hydroxy-4-methylthiobutanioc acid or salts thereof 失效用于制备2-羟基-4-甲硫基丁酸或其盐的连续水解方法
公开(公告)号：US5856567A
公开(公告)日：1999-01-05
申请号：US647161
申请日：1996-05-21
IPC分类号： A23K1/16 , B01J14/00 , B01J19/18 , B01J19/24 , C07C319/18 , C07C319/20 , C07C323/52 , C07C323/60 , C07C381/00 , C07C51/42
CPC分类号： B01J19/1837 , A23K20/105 , B01J14/00 , B01J19/18 , B01J19/1862 , B01J19/1881 , B01J19/24 , B01J19/243 , B01J19/2435 , B01J19/245 , C07C319/18 , C07C319/20 , B01J2219/00013 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/00099 , B01J2219/00103 , B01J2219/0011 , B01J2219/00166 , B01J2219/185
摘要： A continuous process for the preparation of 2-hydroxy-4-methylthiobutanoic acid or a salt thereof which includes introducing an aqueous mineral acid into a nitrile hydrolysis reactor including a continuous stirred tank reactor and introducing 2-hydroxy-4-methylthiobutanenitrile into the nitrile hydrolysis reactor. 2-hydroxy-4-methylthiobutanenitrile is continually hydrolyzed within the nitrile hydrolysis reactor to produce a nitrile hydrolysis reactor product stream containing 2-hydroxy-4-methylthiobutanamide. The nitrile hydrolysis reactor product stream is continuously introduced into an amide hydrolysis flow reactor. 2-hydroxy-4-methylthiobutanamide is continually hydrolyzed within the amide hydrolysis flow reactor to produce an aqueous hydrolyzate product containing 2-hydroxy-4-methylthiobutanoic acid. 2-hydroxy-4-methylthiobutanoic acid is recovered from the aqueous hydrolyzate product.
摘要翻译： 一种用于制备2-羟基-4-甲硫基丁酸或其盐的连续方法，其包括将无机酸水溶液引入腈水解反应器，包括连续搅拌釜反应器并将2-羟基-4-甲硫基丁腈引入腈水解 反应堆。 在腈水解反应器内不断水解2-羟基-4-甲硫基丁腈，生成含有2-羟基-4-甲硫基丁酰胺的腈水解反应器产物流。 将腈水解反应器产物流连续引入酰胺水解流反应器。 2-氨基-4-甲硫基丁酰胺在酰胺水解流反应器内连续水解，得到含有2-羟基-4-甲硫基丁酸的含水解产物。 从水解产物水溶液中回收2-羟基-4-甲硫基丁酸。
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