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1.发明授权1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine -3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines 失效1-环丙基-6,7-二卤代-1,4-二氢-4-氧代-1,8-二氮杂萘-3-羧酸及其酯，可用作制备7-胺取代的萘啶的中间体
公开(公告)号：US4663457A
公开(公告)日：1987-05-05
申请号：US765099
申请日：1985-08-13
IPC分类号： C07D213/74 , C07D215/56 , C07D401/04 , C07D407/12 , C07D471/04
CPC分类号： C07D213/74 , C07D215/56 , C07D401/04 , C07D407/12 , C07D471/04
摘要： 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their esters, which are useful as intermediates for the preparation of compounds which are useful as anti-bacterial agents.
摘要翻译： 1-环丙基-6,7-二卤代-1,4-二氢-4-氧代-1,8-二氮杂萘-3-羧酸及其酯，它们可用作制备可用作抗反应性的化合物的中间体， 细菌剂。
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公开(公告)号：US5097032A
公开(公告)日：1992-03-17
申请号：US537548
申请日：1990-06-13
IPC分类号： C07D401/04 , C07D471/04 , C07D487/10 , C07D498/06 , C07D519/00
CPC分类号： C07D401/04 , C07D471/04 , C07D487/10
摘要： Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
摘要翻译： 描述了作为抗菌剂的新型萘啶，喹啉和苯并恶嗪羧酸以及其制备，配制和用于治疗细菌感染的方法，包括用于制备抗菌剂的某些新型中间体的描述。
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3.发明授权4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents 失效4-氧代-1,4-二氢喹啉-3-羧酸衍生物作为抗菌剂
公开(公告)号：US4822801A
公开(公告)日：1989-04-18
申请号：US920536
申请日：1986-10-20
IPC分类号： C07D215/56 , A61K31/435 , A61K31/47 , A61K31/535 , A61K31/5383 , A61P31/04 , C07D401/04 , C07D471/04 , C07D487/10 , C07D498/04 , C07D498/06 , C07D519/00 , C07D401/02
CPC分类号： C07D401/04 , C07D471/04 , C07D487/10
摘要： Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
摘要翻译： 描述了作为抗菌剂的新型萘啶，喹啉和苯并恶嗪羧酸以及其制备，配制和用于治疗细菌感染的方法，包括用于制备抗菌剂的某些新型中间体的描述。
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公开(公告)号：US4665079A
公开(公告)日：1987-05-12
申请号：US692820
申请日：1985-01-23
IPC分类号： C07D498/00 , A61K31/435 , A61K31/47 , A61P31/04 , C07C45/00 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D401/04 , C07D403/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D498/06 , C07D519/00 , A61K31/495
CPC分类号： C07D207/08 , C07C205/45 , C07C45/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D401/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/10
摘要： Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
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公开(公告)号：US5281612A
公开(公告)日：1994-01-25
申请号：US200090
申请日：1988-05-27
IPC分类号： A61K31/435 , C07C45/00 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D317/22 , C07D401/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D498/06 , C07D519/00
CPC分类号： C07D207/08 , C07C45/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D317/22 , C07D401/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/10
摘要： Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
摘要翻译： 描述了新的萘啶羧酸作为抗菌剂，以及其制备，配制和用于治疗细菌感染的方法。
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6.发明授权Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents 失效三氟喹啉-3-羧酸及其作为抗菌剂的用途
公开(公告)号：US4657913A
公开(公告)日：1987-04-14
申请号：US724442
申请日：1985-04-18
IPC分类号： A61K31/455 , A61K31/47 , A61P31/04 , C07D215/56 , C07D401/04 , C07D471/04 , C07D487/10 , C07D519/00 , C07D215/00
CPC分类号： C07D401/04 , C07D471/04 , C07D487/10
摘要： Novel difluoro-naphthyridine- and trifluoroquinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
摘要翻译： 描述了作为抗菌剂的新型二氟 - 萘啶和三氟喹啉羧酸，以及其制备，配制和用于治疗细菌感染的方法，包括用于制造抗菌剂的某些新型中间体的描述。
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公开(公告)号：US4604401A
公开(公告)日：1986-08-05
申请号：US633151
申请日：1984-07-20
IPC分类号： A61K31/47 , A61P31/04 , C07D215/58 , C07D401/04 , C07D471/04 , C07D487/10 , C07D215/22
CPC分类号： C07D401/04 , C07D215/58 , C07D471/04 , C07D487/10
摘要： Novel 1-amino-naphthyridine- and quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.
摘要翻译： 描述了作为抗菌剂的新型1-氨基 - 萘啶和喹啉羧酸以及其制备，配制和用于治疗细菌感染的方法。
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公开(公告)号：US4638067A
公开(公告)日：1987-01-20
申请号：US764357
申请日：1985-08-12
IPC分类号： C07C45/00 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D401/04 , C07D401/14 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/06 , C07D498/06 , C07D519/00 , C07D215/02
CPC分类号： C07D207/08 , C07C205/45 , C07C45/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D401/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/06
摘要： Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
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公开(公告)号：US4771054A
公开(公告)日：1988-09-13
申请号：US896917
申请日：1986-08-15
IPC分类号： C07C45/00 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D401/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/06 , C07D498/06 , C07D519/00 , A61K31/495
CPC分类号： C07D207/08 , C07C205/45 , C07C45/00 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/277 , C07D213/74 , C07D215/56 , C07D265/36 , C07D401/04 , C07D407/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/06
摘要： Novel quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
摘要翻译： 描述了新的喹啉羧酸作为抗菌剂，以及其制备，配制和用于治疗细菌感染的方法，包括描述用于制造抗菌剂的某些新型中间体。
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10.发明授权7-substituted amino-1-aryl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and derivatives thereof as antibacterial agents 失效7-取代的氨基-1-芳基-6,8-二氟-1,4-二氢-4-氧代-3-喹啉羧酸及其衍生物作为抗菌剂
公开(公告)号：US4617308A
公开(公告)日：1986-10-14
申请号：US695145
申请日：1985-01-25
申请人： Thomas F. Mich , John M. Domagala
发明人： Thomas F. Mich , John M. Domagala
IPC分类号： C07D401/04 , C07D417/14
CPC分类号： C07D401/04 , C07D417/14
摘要： Novel 1-aryl or heteroaryl-6,8-difluoro-1,4-dihydro-7-(3-aminomethyl)pyrrolidinyl- or 7-spiroamino-4-oxo-3-quinolinecarboxylic acids and acid derivatives thereof as antibacterial agents are described as well as methods for their manufacture, formulation and use in treating bacterial infections caused by Gram-negative and Gram-positive bacteria.
摘要翻译： 描述新颖的1-芳基或杂芳基-6,8-二氟-1,4-二氢-7-（3-氨基甲基）吡咯烷基 - 或7-螺氨基-4-氧代-3-喹啉羧酸及其酸衍生物作为抗菌剂 以及其制造，配制和用于治疗由革兰氏阴性菌和革兰氏阳性菌引起的细菌感染的方法。
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