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公开(公告)号：US06228867B1
公开(公告)日：2001-05-08
申请号：US09275951
申请日：1999-03-25
IPC分类号： A61K31345
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6077847A
公开(公告)日：2000-06-20
申请号：US275950
申请日：1999-03-25
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5985892A
公开(公告)日：1999-11-16
申请号：US275752
申请日：1999-03-25
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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4.发明授权公开(公告)号：US07015235B2
公开(公告)日：2006-03-21
申请号：US10468515
申请日：2002-02-25
申请人： Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
发明人： Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译： 某些新的4-取代N-酰化哌啶衍生物是人黑皮质素受体的激动剂，特别是人黑皮质素-4受体（MC-4R）的选择性激动剂。 因此，它们可用于治疗，控制或预防对MC-4R的活化反应的疾病和病症，例如肥胖，糖尿病，性功能障碍，包括勃起功能障碍和女性性功能障碍。
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公开(公告)号：US6110931A
公开(公告)日：2000-08-29
申请号：US276028
申请日：1999-03-25
IPC分类号： A61P5/02 , C07D519/00 , A61K31/437 , A61K31/4375 , C07D471/04 , C07D487/04
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US07012084B2
公开(公告)日：2006-03-14
申请号：US10468517
申请日：2002-02-25
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D413/06 , C07D211/26 , C07D211/28 , C07D211/62 , C07D413/14
摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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公开(公告)号：US5998432A
公开(公告)日：1999-12-07
申请号：US276029
申请日：1999-03-25
IPC分类号： C07D519/00 , A61K31/435 , C07D471/04
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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8.发明授权公开(公告)号：US07700778B2
公开(公告)日：2010-04-20
申请号：US11239770
申请日：2005-09-30
IPC分类号： C07D401/06 , A61K31/454 , A61K31/451
CPC分类号： C07D413/06 , C07D211/26 , C07D211/28 , C07D211/62 , C07D413/14
摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译： 某些新的4-取代的N-酰化哌啶衍生物是人类黑皮质素受体的激动剂，特别是人黑皮质素-4受体（MC-4R）的选择性激动剂。 因此，它们可用于治疗，控制或预防对MC-4R的激活反应的疾病和病症，例如肥胖，糖尿病，性功能障碍，包括勃起功能障碍和女性性功能障碍。
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公开(公告)号：US6025366A
公开(公告)日：2000-02-15
申请号：US275754
申请日：1999-03-25
IPC分类号： C07D471/04 , C07D519/00 , A61K31/435
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US06288078B1
公开(公告)日：2001-09-11
申请号：US09520331
申请日：2000-03-07
IPC分类号： C07D47104
CPC分类号： C07D471/04 , A61K31/437
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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