公开(公告)号：US06245026B1

公开(公告)日：2001-06-12

申请号：US09346072

申请日：1999-07-01

申请人： Thomas H. Campbell ,  William L. Sweet ,  David A. Rahdert

发明人： Thomas H. Campbell ,  William L. Sweet ,  David A. Rahdert

IPC分类号： A61B1000

CPC分类号： A61B5/01 ,  A61B5/015 ,  A61B5/6853 ,  A61B8/12 ,  A61B8/4461 ,  A61N5/1002

摘要： A variety of improved thermal mapping catheters are disclosed which are capable of sensing and mapping thermal variations within body vessels. In embodiments directed at vascular applications, the catheters are capable of detecting temperature variations in atherosclerotic plaque, on the atherosclerotic plaque surface, and on the arterial wall of aneurysms and other vascular lesions of the human vasculature. In one aspect of the invention, a combined thermal mapping and drug delivery catheter is provided. In this embodiment a plurality of thermal sensors are combined with at least one infusion port suitable for delivering therapeutic agents into a vessel. In some embodiments, at least some of the infusion ports are located between adjacent thermal sensors. The described catheters may be used in a variety of new applications and medical diagnostic and treatment techniques.

摘要翻译： 公开了能够感测和映射体内血管中的热变化的各种改进的热导图。 在针对血管应用的实施例中，导管能够检测动脉粥样硬化斑块，动脉粥样硬化斑块表面以及动脉瘤的动脉壁和人脉管系统的其它血管损伤的温度变化。 在本发明的一个方面，提供组合的热图和药物输送导管。 在该实施例中，多个热传感器与适合于将治疗剂递送到血管中的至少一个输注端口组合。 在一些实施例中，至少一些输注端口位于相邻的热传感器之间。 所描述的导管可以用于各种新的应用和医疗诊断和治疗技术。

公开(公告)号：US06554758B2

公开(公告)日：2003-04-29

申请号：US09755735

申请日：2001-01-05

申请人： Todd H. Turnlund ,  William L. Sweet

发明人： Todd H. Turnlund ,  William L. Sweet

IPC分类号： A61N500

CPC分类号： A61N5/1002 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12181 ,  A61B17/12186 ,  A61F2/88 ,  A61F2/91 ,  A61F2250/0067

摘要： A method for increasing the rate of thrombus formation and/or proliferative cell growth of a selected region (21) of cellular tissue (22) including the step of endovascularly irradiating the selected region (21) with radiation, having a dose range of endovascular radiation of about 1 Gy to about 600 Gy at a low dose rate of about 1 cGy/hr to about 320 cGy/hr, to increase thrombus formation and/or cell proliferation of the affected selected region (21). Preferably, the delivery means includes a deformable endovascular prosthesis (25) adapted for secured positioning adjacent to the selected region (21) of cellular tissue (22), and a radioactive source. This source cooperates with the deformable endovascular device (25) in a manner endovascularly irradiating the selected region with radiation, having the above-indicated dose range and low dose rate of endovascular radiation to increase thrombus formation and/or cell proliferation of the affected selected region (21).

摘要翻译： 一种用于增加细胞组织（22）的选定区域（21）的血栓形成和/或增殖细胞生长速率的方法，包括用辐射血管内照射所选区域（21）的步骤，所述辐射具有剂量范围的血管内辐射 约1Gy至约600Gy，以约1ccy / hr的低剂量率至约320cGy / hr，以增加受影响的选择区域的血栓形成和/或细胞增殖（21）。 优选地，输送装置包括可变形的血管内假体（25），其适于邻近细胞组织（22）的选定区域（21）附近的固定定位和放射源。 该源与可变形的血管内装置（25）以与血管内照射所选区域的方式以具有上述剂量范围和低剂量率的血管内辐射以增加受影响的选择区域的血栓形成和/或细胞增殖的辐射协同 （21）。

公开(公告)号：US06296603B1

公开(公告)日：2001-10-02

申请号：US09084675

申请日：1998-05-26

申请人： Todd H. Turnlund ,  William L. Sweet

发明人： Todd H. Turnlund ,  William L. Sweet

IPC分类号： A61N500

CPC分类号： A61N5/1002 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12181 ,  A61B17/12186 ,  A61F2/88 ,  A61F2/91 ,  A61F2250/0067

摘要： A method for increasing the rate of thrombus formation and/or proliferative cell growth of a selected region (21) of cellular tissue (22) including the step of endovascularly irradiating the selected region (21) with radiation, having a dose range of endovascular radiation of about 1 Gy to about 600 Gy at a low dose rate of about 1 cGy/hr to about 320 cGy/hr, to increase thrombus formation and/or cell proliferation of the affected selected region (21). Preferably, the delivery means includes a deformable endovascular prosthesis (25) adapted for secured positioning adjacent to the selected region (21) of cellular tissue (22), and a radioactive source. This source cooperates with the deformable endovascular device (25) in a manner endovascularly irradiating the selected region with radiation, having the above-indicated dose range and low dose rate of endovascular radiation to increase thrombus formation and/or cell proliferation of the affected selected region (21).

摘要翻译： 一种用于增加细胞组织（22）的选定区域（21）的血栓形成和/或增殖细胞生长速率的方法，包括用辐射血管内照射所选区域（21）的步骤，所述辐射具有剂量范围的血管内辐射 约1Gy至约600Gy，以约1ccy / hr的低剂量率至约320cGy / hr，以增加受影响的选择区域的血栓形成和/或细胞增殖（21）。 优选地，输送装置包括可变形的血管内假体（25），其适于邻近细胞组织（22）的选定区域（21）附近的固定定位和放射源。 该源与可变形的血管内装置（25）以与血管内照射所选区域的方式以具有上述剂量范围和低剂量率的血管内辐射以增加受影响的选择区域的血栓形成和/或细胞增殖的辐射协同 （21）。