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    Medical device for navigation through anatomy and method of making same
    2.
    发明授权
    Medical device for navigation through anatomy and method of making same 有权
    通过解剖学导航的医疗装置及其制作方法

    公开(公告)号：US08900163B2

    公开(公告)日：2014-12-02

    申请号：US11831850

    申请日：2007-07-31

    申请人： Stephen C. Jacobsen ,  Clark C. Davis ,  Clay W. Northrop ,  Ted W. Layman ,  Kevin T. Olson ,  Edward J. Snyder ,  D. Kent Backman ,  Todd H. Turnlund

    发明人： Stephen C. Jacobsen ,  Clark C. Davis ,  Clay W. Northrop ,  Ted W. Layman ,  Kevin T. Olson ,  Edward J. Snyder ,  D. Kent Backman ,  Todd H. Turnlund

    IPC分类号： A61B5/00 ,  A61M25/00 ,  A61M25/01 ,  A61M25/09

    CPC分类号： A61M25/09 ,  A61M25/0013 ,  A61M25/01 ,  A61M25/09016

    摘要： Medical devices for navigation through anatomy, including guidewires, which may have a core wire, a slotted tubular member, or both. Embodiments may have coils, including non-circular cross-section edge-wound marker coils, extended coil tips, and soldered or glued mesial joint coils. Core wires may have a step, ridge, or taper at the joints to the tubular member, and may be flattened at the distal tip. Radiopaque material may be located inside the tubular member, and the distal tip may be heat treated to make it shapeable. Additional tubular members or coils may be used concentrically or in line and may enhance flexibility, provide radiopacity, reduce friction, or reduce material or manufacturing cost. Tubular members may be chamfered or tapered continuously or incrementally. Slots may be arranged in groups, such as groups of three, and may be equal in depth or unequal in depth to provide a steerable or compressible tip.

    摘要翻译： 用于通过解剖学导航的医疗装置，包括可以具有芯线的导线，开槽的管状构件或两者。 实施例可以具有线圈，包括非圆形横截面边缘卷绕标记线圈，延伸的线圈尖端以及焊接或胶合的中间接合线圈。 芯线可以在与管状构件的接合处具有台阶，脊或锥形，并且可以在远侧末端处变平。 不透射线材料可以位于管状构件内部，并且远侧末端可以被热处理以使其成形。 附加的管状构件或线圈可以同心地或一致地使用，并且可以增强柔性，提供不透射线性，减少摩擦，或减少材料或制造成本。 管状构件可以被连续地或递增地倒角或锥形。 槽可以以三组排成一组，并且可以在深度上相等或者深度不等，以提供可转向或可压缩的尖端。

    Medical device for navigation through anatomy and method of making same
    5.
    发明授权
    Medical device for navigation through anatomy and method of making same 有权
    通过解剖学导航的医疗装置及其制作方法

    公开(公告)号：US08257279B2

    公开(公告)日：2012-09-04

    申请号：US11831908

    申请日：2007-07-31

    申请人： Clark C. Davis ,  Stephen C. Jacobsen ,  Clay W. Northrop ,  Ted W. Layman ,  Kevin T. Olson ,  Edward J. Snyder ,  D. Kent Backman ,  Todd H. Turnlund

    发明人： Clark C. Davis ,  Stephen C. Jacobsen ,  Clay W. Northrop ,  Ted W. Layman ,  Kevin T. Olson ,  Edward J. Snyder ,  D. Kent Backman ,  Todd H. Turnlund

    IPC分类号： A61B5/00 ,  A61M25/00

    CPC分类号： A61M25/09 ,  A61M25/0013 ,  A61M25/01 ,  A61M25/09016

    摘要： Medical devices for navigation through anatomy, including guidewires, which may have a core wire, a slotted tubular member, or both. Embodiments may have coils, including non-circular cross-section edge-wound marker coils, extended coil tips, and soldered or glued mesial joint coils. Core wires may have a step, ridge, or taper at the joints to the tubular member, and may be flattened at the distal tip. Radiopaque material may be located inside the tubular member, and the distal tip may be heat treated to make it shapeable. Additional tubular members or coils may be used concentrically or in line and may enhance flexibility, provide radiopacity, reduce friction, or reduce material or manufacturing cost. Tubular members may be chamfered or tapered continuously or incrementally. Slots may be arranged in groups, such as groups of three, and may be equal in depth or unequal in depth to provide a steerable or compressible tip.

    摘要翻译： 用于通过解剖学导航的医疗装置，包括可以具有芯线的导线，开槽的管状构件或两者。 实施例可以具有线圈，包括非圆形横截面边缘卷绕标记线圈，延伸的线圈尖端以及焊接或胶合的中间接合线圈。 芯线可以在与管状构件的接合处具有台阶，脊或锥形，并且可以在远侧末端处变平。 不透射线材料可以位于管状构件内部，并且远侧末端可以被热处理以使其成形。 附加的管状构件或线圈可以同心地或一致地使用，并且可以增强柔性，提供不透射线性，减少摩擦，或减少材料或制造成本。 管状构件可以被连续地或递增地倒角或锥形。 槽可以以三组排成一组，并且可以在深度上相等或者深度不等，以提供可转向或可压缩的尖端。

    Polymer film for wrapping a stent structure
    6.
    发明授权
    Polymer film for wrapping a stent structure 失效
    用于包裹支架结构的聚合物膜

    公开(公告)号：US5637113A

    公开(公告)日：1997-06-10

    申请号：US355402

    申请日：1994-12-13

    申请人： Joseph M. Tartaglia ,  Joseph P. Loeffler ,  Todd H. Turnlund

    发明人： Joseph M. Tartaglia ,  Joseph P. Loeffler ,  Todd H. Turnlund

    IPC分类号： A61M31/00 ,  A61F2/00 ,  A61F2/82 ,  A61F2/92 ,  A61L27/00 ,  A61L31/00 ,  A61F2/06

    CPC分类号： A61F2/82 ,  A61F2/07 ,  A61F2/92 ,  A61F2/915 ,  A61F2002/075 ,  A61F2220/005 ,  A61F2250/0067

    摘要： The drug loaded stent includes an expandable stent structural member, and a planar sheet of polymeric material attached to the outside of the expandable stent structural member. The polymeric material is preferably bioabsorbable, and loaded or coated with a therapeutic agent or drug to reduce or prevent restenosis in the vessel being treated. The polymer material can be attached to the metal stent at one or more points, and wrapped in a coil around the stent in an unexpanded state, to uncoil and expand in diameter to substantially match the expanded diameter of the metal stent; or can be wrapped tightly around the stent structural member and attached to itself, to stretch radially when the stent structural member is expanded. In another currently preferred embodiment, a combination of a stent structural member and a polymeric film wrapping can be provided with a coating of lubricious material. The lubricious material can be polyethylene oxide, polyethylene glycol, polyethylene acetate, polyvinyl pyrrolidone, polyvinyl alcohol, polyacrylamide, hydrophilic soft segment urethanes, some natural gums, polyanhydrides or other similar hydrophilic polymers, and combinations thereof. The layer of lubricious material protects the stent from the guide or the body lumen in which the stent is inserted by providing a low friction surface over the stent.

    摘要翻译： 药物负载支架包括可扩张的支架结构构件和附接到可扩张支架结构构件的外侧的聚合物材料的平面片。 聚合物材料优选是生物可吸收的，并且加载或涂覆有治疗剂或药物以减少或预防待治疗血管中的再狭窄。 聚合物材料可以以一个或多个点附着到金属支架上，并且以未膨胀的状态包裹在支架周围的线圈中，以直径展开和膨胀以与金属支架的扩张直径基本匹配; 或者可以紧紧地包裹在支架结构构件上并且附接到其自身，以在支架结构构件膨胀时径向拉伸。 在另一个目前优选的实施方案中，支架结构构件和聚合物膜包裹物的组合可以提供有润滑材料的涂层。 润滑材料可以是聚环氧乙烷，聚乙二醇，聚乙酸乙烯酯，聚乙烯吡咯烷酮，聚乙烯醇，聚丙烯酰胺，亲水性软链段聚氨酯，一些天然树胶，聚酐或其它类似的亲水聚合物，及其组合。 光滑材料层通过在支架上提供低摩擦表面来保护支架免于插入支架的引导件或体腔。

    Biodegradable mesh and film stent
    7.
    发明授权
    Biodegradable mesh and film stent 失效
    可生物降解的网膜和薄膜支架

    公开(公告)号：US5629077A

    公开(公告)日：1997-05-13

    申请号：US266964

    申请日：1994-06-27

    申请人： Todd H. Turnlund ,  Robert P. Eury

    发明人： Todd H. Turnlund ,  Robert P. Eury

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/82 ,  A61F2/92 ,  A61L31/06 ,  A61L31/14 ,  B32B7/00

    CPC分类号： A61F2/82 ,  A61F2/93 ,  A61L31/06 ,  A61L31/148 ,  B32B37/04 ,  A61F2/0077 ,  A61F2/07 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2240/001 ,  A61F2250/0067 ,  B32B2367/00 ,  Y10S623/90 ,  Y10T156/1038 ,  Y10T428/1369 ,  Y10T442/164

    摘要： The biodegradable mesh and film stent for use in blood vessels is formed of a sheet of a composite mesh material formed of biodegradable high strength polymer fibers bonded together with a second biodegradable adhesive polymer, and laminated on at least one side with a thin film of a third biodegradable polymer. The biodegradable mesh and film material is formed as a sheet and cut in a shape that can be used as a stent, such as a "belt-buckle" type shape, the ends of which can be joined in a contractible, expandable loop. In the method of making the biodegradable composite mesh and film stent, the composite mesh is preferably formed from a weave formed of high strength biodegradable polymeric fibers, and a plurality of low temperature melting biodegradable polymeric fibers. In an alternate embodiment, the high strength fibers are commingled with the low temperature melting fibers. In another alternate embodiment, the high strength fibers are coated with the low temperature melting polymer. The composite mesh is covered on at least one side by a laminating film, and is then cut into the shape of the stent.

    摘要翻译： 用于血管的可生物降解的网膜和薄膜支架由一片由可生物降解的高强度聚合物纤维形成的复合网格材料形成，该聚合物纤维与第二可生物降解的粘合剂聚合物结合在一起，并且在至少一侧上用薄膜 第三种可生物降解的聚合物。 可生物降解的网状物和薄膜材料形成为片材，并且被切割成能够用作支架的形状，例如“带扣”形状，其端部可以以可收缩的可扩张环接合。 在制造可生物降解复合网和膜支架的方法中，复合网优选由由高强度可生物降解的聚合物纤维形成的织物和多个低温熔融的可生物降解的聚合物纤维形成。 在替代实施例中，高强度纤维与低温熔融纤维混合。 在另一个替代实施例中，高强度纤维被低温熔融聚合物涂覆。 复合网在至少一侧用层压膜覆盖，然后切割成支架的形状。

    LASER SHOCK PEENING OF MEDICAL DEVICES
    9.
    发明申请
    LASER SHOCK PEENING OF MEDICAL DEVICES 审中-公开
    医疗器械激光冲击

    公开(公告)号：US20090043228A1

    公开(公告)日：2009-02-12

    申请号：US11834496

    申请日：2007-08-06

    申请人： CLAY W. NORTHROP ,  TED W. LAYMAN ,  TODD H. TURNLUND

    发明人： CLAY W. NORTHROP ,  TED W. LAYMAN ,  TODD H. TURNLUND

    IPC分类号： A61M25/01

    CPC分类号： C21D10/005 ,  A61F2/91 ,  A61M25/0013 ,  A61M25/0043 ,  C21D7/04 ,  C21D7/06

    摘要： A laser shock peening process for producing one or more compressive residual stress regions in a medical device is disclosed. A high-energy laser apparatus can be utilized to direct an intense laser beam through a confining medium and onto the target surface of a workpiece. An absorption overlay disposed on the target surface of the workpiece absorbs the laser beam, inducing a pressure shock wave that forms a compressive residual stress region deep within the workpiece. Medical devices such as stents, guidewires, catheters, and the like having one or more of these compressive residual stress regions are also disclosed.

    摘要翻译： 公开了一种用于在医疗装置中产生一个或多个压缩残余应力区域的激光冲击硬化方法。 可以使用高能激光装置将强激光束引导通过约束介质和工件的目标表面。 设置在工件的目标表面上的吸收层吸收激光束，引起在工件内部形成压缩残余应力区域的压力冲击波。 还公开了具有这些压缩残余应力区域中的一个或多个的医疗装置，例如支架，导丝，导管等。

    Radioactive intraluminal endovascular prothesis and method for the treatment of aneurysms
    10.
    发明授权
    Radioactive intraluminal endovascular prothesis and method for the treatment of aneurysms 失效
    放射性管腔内血管假体和治疗动脉瘤的方法

    公开(公告)号：US06554758B2

    公开(公告)日：2003-04-29

    申请号：US09755735

    申请日：2001-01-05

    申请人： Todd H. Turnlund ,  William L. Sweet

    发明人： Todd H. Turnlund ,  William L. Sweet

    IPC分类号： A61N500

    CPC分类号： A61N5/1002 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12181 ,  A61B17/12186 ,  A61F2/88 ,  A61F2/91 ,  A61F2250/0067

    摘要： A method for increasing the rate of thrombus formation and/or proliferative cell growth of a selected region (21) of cellular tissue (22) including the step of endovascularly irradiating the selected region (21) with radiation, having a dose range of endovascular radiation of about 1 Gy to about 600 Gy at a low dose rate of about 1 cGy/hr to about 320 cGy/hr, to increase thrombus formation and/or cell proliferation of the affected selected region (21). Preferably, the delivery means includes a deformable endovascular prosthesis (25) adapted for secured positioning adjacent to the selected region (21) of cellular tissue (22), and a radioactive source. This source cooperates with the deformable endovascular device (25) in a manner endovascularly irradiating the selected region with radiation, having the above-indicated dose range and low dose rate of endovascular radiation to increase thrombus formation and/or cell proliferation of the affected selected region (21).

    摘要翻译： 一种用于增加细胞组织（22）的选定区域（21）的血栓形成和/或增殖细胞生长速率的方法，包括用辐射血管内照射所选区域（21）的步骤，所述辐射具有剂量范围的血管内辐射 约1Gy至约600Gy，以约1ccy / hr的低剂量率至约320cGy / hr，以增加受影响的选择区域的血栓形成和/或细胞增殖（21）。 优选地，输送装置包括可变形的血管内假体（25），其适于邻近细胞组织（22）的选定区域（21）附近的固定定位和放射源。 该源与可变形的血管内装置（25）以与血管内照射所选区域的方式以具有上述剂量范围和低剂量率的血管内辐射以增加受影响的选择区域的血栓形成和/或细胞增殖的辐射协同 （21）。