摘要:
The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.
摘要:
The invention relates to antibacterial ester macrocycles of formula (I), methods for the production thereof, and the use thereof for producing medicaments used for the treatment and/or prophylaxis of diseases, particularly bacterial infections.
摘要:
The invention relates to antibacterial amide macrocycles and process for their preparation, their use for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.
摘要:
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions comprising them, and their use in the treatment of diseases in humans or animals.
摘要:
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions comprising them, and their use in the treatment of diseases in humans or animals.
摘要:
The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester or 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester benzene sulfonate (P) which comprises reacting 3-[(S)-7-bromo-2-((R and/or S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]-propionic acid methyl ester of formula (EM) with an oxidizing agent and optionally treating the reaction product under acidic conditions, such as to produce the compound of formula (F) or the compound (P), and new compounds useful as starting material or as intermediate for performing that process.
摘要:
The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要:
A power switch disposed in a housing includes a contact breaker configured to connect and disconnect a low-voltage switchgear from a power source supplying the low-voltage switchgear, a triggering device configured to disconnect the low-voltage switchgear in an overload event, a current detection device, a control device, a first evaluation device configured to evaluate an accidental arc overcurrent, and a second evaluation device configured to evaluate the accidental arc overcurrent. The power switch is configured to be activated via an overcurrent signal generated by an arc monitoring system in response to the accidental arc overcurrent. The overcurrent signal is linked to the at least one triggering signal. The second evaluation has a threshold above a threshold of the first evaluation device. The triggering device is configured to be activated via a turn-off pulse when a signal from the current detection device is above the threshold of the second evaluation device.
摘要:
A circuit breaker for multi-phase power includes an opening-closing apparatus configured to open and close each phase of the multiphase power, a detection unit configured to detect a fault current in at least one phase of an electrical installation being protected by the circuit breaker, a plurality of connecting bars disposed on a load side of the circuit breaker, and a short circuiter disposed on the connecting bars and configured to produce a short circuit between the connecting bars if a fault current is detected by the fault-current detection unit. When a fault current occurs, a tripping signal can be transmitted by the detection system to the short circuiter. The circuit breaker is also fully operational, even without a function-activated short circuiter.
摘要:
The invention relates to a method for producing an optical arrangement (10, 300), in which an optical component (355, 20) is optically connected to at least one waveguide (90, 320, 330) provided on or in a carrier substrate (100, 310). In order to enable an optical component to be connected to an optical waveguide of a carrier substrate in a particularly simple and thus cost-effective manner, the invention provides for there to be arranged between the optical component (20, 355) and the waveguide (90, 320, 330) an adjustment device (40, 350) with at least one auxiliary waveguide (60, 410, 440), the waveguide ends (50, 70, 400, 420, 430, 450) of which are in each case movable and an optical adjustment between the optical component (20, 355) and the waveguide (90, 320, 330) of the carrier substrate (100, 310) is effected by a mechanical adjustment of the movable waveguide ends (50, 70, 400, 420, 430, 450).