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公开(公告)号:US07357799B2
公开(公告)日:2008-04-15
申请号:US10457088
申请日:2003-06-06
IPC分类号: A61B18/14
CPC分类号: A61B18/14 , A61B2018/0044 , A61B2018/1467 , A61B2018/1472
摘要: This invention relates to the use of hyperconductive fluids to coagulate tissue within the intervertebral disc.
摘要翻译: 本发明涉及使用超导流体凝固椎间盘内的组织。
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2.Method of identifying and treating a pathologic region of an intervertebral disc 有权
标题翻译: 识别和治疗椎间盘病理区域的方法公开(公告)号:US06827716B2
公开(公告)日:2004-12-07
申请号:US10261215
申请日:2002-09-30
IPC分类号: A61B1818
CPC分类号: A61B18/1492 , A61B2017/00057 , A61B2017/00261 , A61B2018/0044 , A61N7/02
摘要: This invention relates to a method of treating an intervertebral disc comprising locally identifying a pathologic tissue site and therapeutically treating the identified site.
摘要翻译: 本发明涉及一种治疗椎间盘的方法,其包括局部鉴定病理组织部位并治疗所述鉴定部位。
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3.Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权
标题翻译: 将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号:US08361467B2
公开(公告)日:2013-01-29
申请号:US10630227
申请日:2003-07-30
申请人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号: A61K39/395 , A61K39/00 , A61K38/18
CPC分类号: A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译: 本发明涉及向患病关节中透射施用高特异性拮抗剂,所述高特异性拮抗剂选自:i)促炎白细胞介素的抑制剂; ii)TNF-α合成抑制剂; iii)膜结合TNF-α的抑制剂; iv)TNF-α的天然受体的抑制剂; v)NO合酶抑制剂,vi)PLA2酶抑制剂; vii)抗增殖剂; viii)抗氧化剂; ix)选自EPO模拟肽,EPO模拟物,IGF-I,IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂,和x)MMP的抑制剂; 和xi)p38激酶的抑制剂。
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公开(公告)号:US20090248076A1
公开(公告)日:2009-10-01
申请号:US12055757
申请日:2008-03-26
CPC分类号: A61B17/7062
摘要: An interspinous spacer having a pair of hooks that, upon lateral insertion between opposed spinous process, bear upon the opposed spinous processes.
摘要翻译: 棘突间隔物具有一对钩,当在相对的棘突之间横向插入时,它们承受相对的棘突。
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公开(公告)号:US08025678B2
公开(公告)日:2011-09-27
申请号:US12055757
申请日:2008-03-26
IPC分类号: A61B17/70
CPC分类号: A61B17/7062
摘要: An interspinous spacer having a pair of hooks that, upon lateral insertion between opposed spinous process, bear upon the opposed spinous processes.
摘要翻译: 棘突间隔物具有一对钩,当在相对的棘突之间横向插入时,它们承受相对的棘突。
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6.
公开(公告)号:US20090248079A1
公开(公告)日:2009-10-01
申请号:US12239631
申请日:2008-09-26
申请人: Seungkyu Daniel Kwak , Mark Gracia , John Riley Hawkins , Lisa Gilman , John Griffin , Martin A. Reynolds , Hassan Serhan
发明人: Seungkyu Daniel Kwak , Mark Gracia , John Riley Hawkins , Lisa Gilman , John Griffin , Martin A. Reynolds , Hassan Serhan
CPC分类号: A61B17/7062 , A61B17/7053 , A61B17/7065
摘要: An S-shaped interspinous spacer having a pair of hooks that, upon lateral insertion between opposed spinous process, bear upon the opposed spinous processes.
摘要翻译: 具有一对钩的S形棘突间间隔物,其在相对的棘突之间横向插入时承受相对的棘突。
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7.
公开(公告)号:US08313512B2
公开(公告)日:2012-11-20
申请号:US12239631
申请日:2008-09-26
申请人: Seungkyu Daniel Kwak , Mark Gracia , John Riley Hawkins , Lisa Gilman , John Griffin , Martin A. Reynolds , Hassan Serhan
发明人: Seungkyu Daniel Kwak , Mark Gracia , John Riley Hawkins , Lisa Gilman , John Griffin , Martin A. Reynolds , Hassan Serhan
IPC分类号: A61B17/70
CPC分类号: A61B17/7062 , A61B17/7053 , A61B17/7065
摘要: An S-shaped interspinous spacer having a pair of hooks that, upon lateral insertion between opposed spinous process, bear upon the opposed spinous processes.
摘要翻译: 具有一对钩的S形棘突间间隔物,其在相对的棘突之间横向插入时承受相对的棘突。
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公开(公告)号:US08845733B2
公开(公告)日:2014-09-30
申请号:US13163427
申请日:2011-06-17
IPC分类号: A61F2/44 , A61M29/02 , A61B17/17 , A61B17/16 , A61M25/00 , A61B5/00 , A61M25/01 , A61B17/02 , A61B17/34
CPC分类号: A61F2/4455 , A61B5/4893 , A61B17/1659 , A61B17/1671 , A61B17/1757 , A61B2017/0256 , A61B2017/3433 , A61F2/30771 , A61F2/4425 , A61F2/446 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2/4637 , A61F2002/30326 , A61F2002/30523 , A61F2002/30593 , A61F2002/443 , A61F2002/4623 , A61F2002/4642 , A61M25/0054 , A61M25/0133 , A61M29/02
摘要: An intervertebral fusion device comprising inferior and superior fusion cage devices that provide an ability to correct spondylolisthesis via in-situ adjustment.
摘要翻译: 一种椎间融合装置,其包括通过原位调整提供矫正脊椎前移的能力的下部和上部融合笼装置。
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9.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US08728523B2
公开(公告)日:2014-05-20
申请号:US12291378
申请日:2008-11-07
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K45/00 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
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公开(公告)号:US08636802B2
公开(公告)日:2014-01-28
申请号:US10793967
申请日:2004-03-06
IPC分类号: A61F2/44
CPC分类号: A61B17/7065 , A61B17/7062 , A61B17/7068 , A61B2017/00075 , A61B2017/00221 , A61B2017/00964 , A61B2017/567 , A61B2017/681 , A61F2/4405 , A61F2002/482
摘要: An interspinous process having a general horseshoe shape, a cushion element within the horseshoe and a porous coating on its outer surface.
摘要翻译: 具有一般马蹄形的棘突间过程,马蹄形内的缓冲元件和其外表面上的多孔涂层。
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