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1.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂公开(公告)号：US20070270476A1
公开(公告)日：2007-11-22
申请号：US11830318
申请日：2007-07-30
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
IPC分类号： A61K31/4164 , A61K31/426 , A61P29/00 , A61P31/04 , A61P35/00 , C07D235/04 , C07D277/20
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20070112047A1
公开(公告)日：2007-05-17
申请号：US11560166
申请日：2006-11-15
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
IPC分类号： A61K31/427 , A61K31/4184 , C07D413/04 , C07D235/04
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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3.发明申请公开(公告)号：US20060229351A1
公开(公告)日：2006-10-12
申请号：US11401635
申请日：2006-04-11
申请人： Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Thomas Penning , Vincent Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Thomas Penning , Vincent Giranda , Sheela Thomas
IPC分类号： A61K31/4184
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包括式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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4.发明申请1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权在2位置上被苯基取代的苯并咪唑-4-羧酰胺是一种残留的PARP抑制剂公开(公告)号：US20070179136A1
公开(公告)日：2007-08-02
申请号：US11536994
申请日：2006-09-29
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Vincent Giranda
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Vincent Giranda
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4184 , C07D413/14 , C07D403/02
CPC分类号： C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
摘要： Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
摘要翻译： 具有式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含具有式（I）的化合物，包括具有式（I）的化合物的处理方法的药物组合物，以及包含具有式（I）的化合物的PARP酶的抑制方法。
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公开(公告)号：US20070249597A1
公开(公告)日：2007-10-25
申请号：US11675570
申请日：2007-02-15
IPC分类号： A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , A61P29/00
CPC分类号： C07D471/04 , A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , C07D491/04 , C07D495/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20060229289A1
公开(公告)日：2006-10-12
申请号：US11401638
申请日：2006-04-11
IPC分类号： A61K31/55 , A61K31/454 , A61K31/4184 , C07D403/04
CPC分类号： C07D403/04 , C07D207/16 , C07D401/04 , C07D401/14 , C07D405/14
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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7.发明申请公开(公告)号：US20100234425A1
公开(公告)日：2010-09-16
申请号：US12765293
申请日：2010-04-22
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
IPC分类号： A61K31/4184 , C07D235/04 , C07D235/14 , C07D403/02 , C07D401/00 , A61K31/4439 , A61K31/4545 , A61P29/00
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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8.发明授权公开(公告)号：US07728026B2
公开(公告)日：2010-06-01
申请号：US11401635
申请日：2006-04-11
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包括式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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9.发明授权公开(公告)号：US08217070B2
公开(公告)日：2012-07-10
申请号：US12765293
申请日：2010-04-22
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Jianchun Gong , Thomas D. Penning , Vincent L. Giranda , Sheela Thomas
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US08466150B2
公开(公告)日：2013-06-18
申请号：US12138168
申请日：2008-06-12
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： A61K31/502 , A61K31/551 , A61K45/06 , A61N5/10 , C07D237/32 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14
摘要： Inhibitors of poly(ADP-ribose)polymerase, ways to make them and methods of treating patients using them are disclosed.
摘要翻译： 公开了聚（ADP-核糖）聚合酶的抑制剂，其制备方法和使用它们治疗患者的方法。
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