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1.发明申请公开(公告)号：US20060229351A1
公开(公告)日：2006-10-12
申请号：US11401635
申请日：2006-04-11
申请人： Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Thomas Penning , Vincent Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Thomas Penning , Vincent Giranda , Sheela Thomas
IPC分类号： A61K31/4184
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包括式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20070249597A1
公开(公告)日：2007-10-25
申请号：US11675570
申请日：2007-02-15
IPC分类号： A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , A61P29/00
CPC分类号： C07D471/04 , A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , C07D491/04 , C07D495/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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3.发明申请1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权在2位置上被苯基取代的苯并咪唑-4-羧酰胺是一种残留的PARP抑制剂公开(公告)号：US20070179136A1
公开(公告)日：2007-08-02
申请号：US11536994
申请日：2006-09-29
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Vincent Giranda
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Vincent Giranda
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4184 , C07D413/14 , C07D403/02
CPC分类号： C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
摘要： Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
摘要翻译： 具有式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含具有式（I）的化合物，包括具有式（I）的化合物的处理方法的药物组合物，以及包含具有式（I）的化合物的PARP酶的抑制方法。
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公开(公告)号：US20060229289A1
公开(公告)日：2006-10-12
申请号：US11401638
申请日：2006-04-11
IPC分类号： A61K31/55 , A61K31/454 , A61K31/4184 , C07D403/04
CPC分类号： C07D403/04 , C07D207/16 , C07D401/04 , C07D401/14 , C07D405/14
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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公开(公告)号：US20080108659A1
公开(公告)日：2008-05-08
申请号：US11867369
申请日：2007-10-04
IPC分类号： A61K31/454 , C07D401/00 , A61K31/4035 , A61P37/08 , A61P35/00 , A61P39/02 , A61K31/4025 , C07D209/44
CPC分类号： C07D209/44 , C07D209/46 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06
摘要： Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
摘要翻译： 公开了抑制聚（ADP-核糖）聚合酶活性的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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6.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂公开(公告)号：US20070270476A1
公开(公告)日：2007-11-22
申请号：US11830318
申请日：2007-07-30
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
IPC分类号： A61K31/4164 , A61K31/426 , A61P29/00 , A61P31/04 , A61P35/00 , C07D235/04 , C07D277/20
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20070112047A1
公开(公告)日：2007-05-17
申请号：US11560166
申请日：2006-11-15
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
IPC分类号： A61K31/427 , A61K31/4184 , C07D413/04 , C07D235/04
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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公开(公告)号：US06831175B2
公开(公告)日：2004-12-14
申请号：US10317914
申请日：2002-12-12
申请人： Qun Li , Keith W. Woods , Gui-Dong Zhu , John P. Fischer , Jianchun Gong , Tongmei Li , Virajkumar Gandhi , Sheela A. Thomas , Garrick K. Packard , Xiaohong Song , Jason N. Abrams , Robert B. Diebold , Jürgen Dinges , Charles W. Hutchins , Vincent S. Stoll , Saul H. Rosenberg , Vincent L. Giranda
发明人： Qun Li , Keith W. Woods , Gui-Dong Zhu , John P. Fischer , Jianchun Gong , Tongmei Li , Virajkumar Gandhi , Sheela A. Thomas , Garrick K. Packard , Xiaohong Song , Jason N. Abrams , Robert B. Diebold , Jürgen Dinges , Charles W. Hutchins , Vincent S. Stoll , Saul H. Rosenberg , Vincent L. Giranda
IPC分类号： C07D21136
CPC分类号： C07D401/04 , C07D213/63 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D475/02
摘要： Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
摘要翻译： 具有该化学式的化合物可用于抑制蛋白激酶。 还公开了抑制蛋白激酶的组合物和抑制患者蛋白激酶的方法。
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公开(公告)号：US08383623B2
公开(公告)日：2013-02-26
申请号：US13086580
申请日：2011-04-14
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC分类号： A01N43/58 , A61K31/50 , C07D237/30
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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10.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂公开(公告)号：US20090186877A1
公开(公告)日：2009-07-23
申请号：US12413834
申请日：2009-03-30
申请人： Vincent L. Giranda , Thomas D. Penning , Virajkumar B. Gandhi , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong
发明人： Vincent L. Giranda , Thomas D. Penning , Virajkumar B. Gandhi , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong
IPC分类号： A61K31/551 , C07D235/06 , A61K31/4184 , C07D403/02 , A61P35/00
CPC分类号： C07D403/10 , C07D235/18 , C07D409/04
摘要： The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
摘要翻译： 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。
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